TIPRL — 20 ClinVar variants
All ClinVar germline TIPRL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
20 Uncertain significance
Full TIPRL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TIPRL p.Arg56Gly Uncertain significance Single submitter
- TIPRL p.Asp264Val Uncertain significance Single submitter
- TIPRL p.Asp38Asn Uncertain significance Single submitter
- TIPRL p.Gln146His Uncertain significance Single submitter
- TIPRL p.Leu125Phe Uncertain significance Single submitter
- TIPRL p.Leu231Val Uncertain significance Single submitter
- TIPRL p.Lys148Asn Uncertain significance Single submitter
- TIPRL p.Lys220Arg Uncertain significance Single submitter
- TIPRL p.Met82Val Uncertain significance Single submitter
- TIPRL p.Ser169Arg Uncertain significance Single submitter
- TIPRL p.Ser268Arg Uncertain significance Single submitter
- TIPRL p.Ser268Gly Uncertain significance Single submitter
- TIPRL p.Thr133Ala Uncertain significance Single submitter
- TIPRL p.Thr138Lys Uncertain significance Single submitter
- TIPRL p.Thr233Met Uncertain significance Single submitter
- TIPRL p.Val130Ile Uncertain significance Single submitter
- TIPRL p.Val174Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All TIPRL variants
Uncertain significance 20
- p.Arg184Gln Single submitter ⚠
- p.Arg56Gly Single submitter ⚠
- p.Asp264Val Single submitter ⚠
- p.Asp38Asn Single submitter ⚠
- p.Gln146His Single submitter ⚠
- p.Leu125Phe Single submitter ⚠
- p.Leu231Val Single submitter ⚠
- p.Lys148Asn Single submitter ⚠
- p.Lys220Arg Single submitter ⚠
- p.Met82Val Single submitter ⚠
- p.Ser169Arg Single submitter ⚠
- p.Ser177Cys Single submitter ⚠
- p.Ser268Arg Single submitter ⚠
- p.Ser268Gly Single submitter ⚠
- p.Thr133Ala Single submitter ⚠
- p.Thr133Ile Single submitter ⚠
- p.Thr138Lys Single submitter ⚠
- p.Thr233Met Single submitter ⚠
- p.Val130Ile Single submitter ⚠
- p.Val174Ile Single submitter ⚠