TM9SF2 — 48 ClinVar variants
All ClinVar germline TM9SF2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
3 Likely benign · 45 Uncertain significance
Full TM9SF2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TM9SF2 p.Ala621Thr Uncertain significance Single submitter
- TM9SF2 p.Ala86Val Uncertain significance Single submitter
- TM9SF2 p.Arg104Gly Uncertain significance Single submitter
- TM9SF2 p.Arg32Leu Uncertain significance Single submitter
- TM9SF2 p.Arg32Trp Uncertain significance Single submitter
- TM9SF2 p.Arg509His Uncertain significance Single submitter
- TM9SF2 p.Asn505Ser Uncertain significance Single submitter
- TM9SF2 p.Asp246Gly Uncertain significance Single submitter
- TM9SF2 p.Asp278Asn Uncertain significance Single submitter
- TM9SF2 p.Glu140Gln Uncertain significance Single submitter
- TM9SF2 p.Glu49Lys Uncertain significance Single submitter
- TM9SF2 p.Glu50Gln Uncertain significance Single submitter
- TM9SF2 p.Glu50Val Uncertain significance Single submitter
- TM9SF2 p.Glu59Lys Uncertain significance Single submitter
- TM9SF2 p.Glu59Val Uncertain significance Single submitter
- TM9SF2 p.Gly34Cys Uncertain significance Single submitter
- TM9SF2 p.Ile180Val Uncertain significance Single submitter
- TM9SF2 p.Ile184Val Uncertain significance Single submitter
- TM9SF2 p.Ile605Val Uncertain significance Single submitter
- TM9SF2 p.Leu5Val Uncertain significance Single submitter
- TM9SF2 p.Leu8Phe Uncertain significance Single submitter
- TM9SF2 p.Lys429Asn Uncertain significance Single submitter
- TM9SF2 p.Met159Ile Uncertain significance Single submitter
- TM9SF2 p.Phe421Leu Uncertain significance Single submitter
- TM9SF2 p.Ser197Thr Uncertain significance Single submitter
- TM9SF2 p.Thr339Met Uncertain significance Single submitter
- TM9SF2 p.Thr401Met Uncertain significance Single submitter
- TM9SF2 p.Thr573Asn Uncertain significance Single submitter
- TM9SF2 p.Thr573Pro Uncertain significance Single submitter
- TM9SF2 p.Thr618Met Uncertain significance Single submitter
- TM9SF2 p.Thr620Ile Uncertain significance Single submitter
- TM9SF2 p.Thr623Ile Uncertain significance Single submitter
- TM9SF2 p.Val318Gly Uncertain significance Single submitter
- TM9SF2 p.Val7Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- TM9SF2 p.Ala583Val Uncertain significance Single submitter
- TM9SF2 p.His298Pro Uncertain significance Single submitter
- TM9SF2 p.Met294Val Uncertain significance Single submitter
- TM9SF2 p.Phe81Tyr Uncertain significance Single submitter
- TM9SF2 p.Pro30Arg Uncertain significance Single submitter
- TM9SF2 p.Ser145Asn Uncertain significance Single submitter
- TM9SF2 p.Ser262Phe Uncertain significance Single submitter
- TM9SF2 p.Thr125Ala Uncertain significance Single submitter
- TM9SF2 p.Thr518Met Uncertain significance Single submitter
- TM9SF2 p.Val660Leu Uncertain significance Single submitter
All TM9SF2 variants
Likely benign 3
- p.Glu276Gln Single submitter
- p.Glu276Lys Single submitter
- p.Val7Ala Single submitter
Uncertain significance 45
- p.Ala583Val Single submitter ⚠
- p.Ala621Thr Single submitter ⚠
- p.Ala86Val Single submitter ⚠
- p.Arg104Gly Single submitter ⚠
- p.Arg32Leu Single submitter ⚠
- p.Arg32Trp Single submitter ⚠
- p.Arg509His Single submitter ⚠
- p.Asn505Ser Single submitter ⚠
- p.Asp246Gly Single submitter ⚠
- p.Asp278Asn Single submitter ⚠
- p.Glu140Gln Single submitter ⚠
- p.Glu49Lys Single submitter ⚠
- p.Glu50Gln Single submitter ⚠
- p.Glu50Val Single submitter ⚠
- p.Glu59Lys Single submitter ⚠
- p.Glu59Val Single submitter ⚠
- p.Gly34Cys Single submitter ⚠
- p.His298Pro Single submitter ⚠
- p.Ile180Val Single submitter ⚠
- p.Ile184Val Single submitter ⚠
- p.Ile605Val Single submitter ⚠
- p.Leu5Val Single submitter ⚠
- p.Leu8Phe Single submitter ⚠
- p.Lys429Asn Single submitter ⚠
- p.Met159Ile Single submitter ⚠
- p.Met294Val Single submitter ⚠
- p.Phe421Leu Single submitter ⚠
- p.Phe81Tyr Single submitter ⚠
- p.Pro30Arg Single submitter ⚠
- p.Ser145Asn Single submitter ⚠
- p.Ser197Thr Single submitter ⚠
- p.Ser262Phe Single submitter ⚠
- p.Thr125Ala Single submitter ⚠
- p.Thr339Met Single submitter ⚠
- p.Thr401Met Single submitter ⚠
- p.Thr518Met Single submitter ⚠
- p.Thr573Asn Single submitter ⚠
- p.Thr573Pro Single submitter ⚠
- p.Thr618Met Single submitter ⚠
- p.Thr620Ile Single submitter ⚠
- p.Thr623Ile Single submitter ⚠
- p.Trp651Cys Single submitter
- p.Val318Gly Single submitter ⚠
- p.Val660Leu Single submitter ⚠
- p.Val7Leu Single submitter ⚠