TMEM161A — 78 ClinVar variants
All ClinVar germline TMEM161A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
2 Likely benign · 76 Uncertain significance
Full TMEM161A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 60
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TMEM161A p.Ala161Ser Uncertain significance Single submitter
- TMEM161A p.Ala161Thr Uncertain significance Single submitter
- TMEM161A p.Ala250Thr Uncertain significance Single submitter
- TMEM161A p.Ala357Val Uncertain significance Single submitter
- TMEM161A p.Ala418Val Uncertain significance Single submitter
- TMEM161A p.Ala437Ser Uncertain significance Single submitter
- TMEM161A p.Ala52Val Uncertain significance Single submitter
- TMEM161A p.Ala65Ser Uncertain significance Single submitter
- TMEM161A p.Arg156Trp Uncertain significance Single submitter
- TMEM161A p.Arg228Cys Uncertain significance Single submitter
- TMEM161A p.Arg254Gln Uncertain significance Single submitter
- TMEM161A p.Arg254Trp Uncertain significance Single submitter
- TMEM161A p.Arg290Gln Uncertain significance Single submitter
- TMEM161A p.Arg358His Uncertain significance Single submitter
- TMEM161A p.Arg363Thr Uncertain significance Single submitter
- TMEM161A p.Arg49Gln Uncertain significance Single submitter
- TMEM161A p.Arg78Gln Uncertain significance Single submitter
- TMEM161A p.Glu163Asp Uncertain significance Single submitter
- TMEM161A p.Glu189Asp Uncertain significance Single submitter
- TMEM161A p.Glu193Lys Uncertain significance Single submitter
- TMEM161A p.Glu62Gly Uncertain significance Single submitter
- TMEM161A p.Gly115Ser Uncertain significance Single submitter
- TMEM161A p.Gly403Asp Uncertain significance Single submitter
- TMEM161A p.Gly421Cys Uncertain significance Single submitter
- TMEM161A p.Gly423Arg Uncertain significance Single submitter
- TMEM161A p.Ile227Leu Uncertain significance Single submitter
- TMEM161A p.Ile455Thr Uncertain significance Single submitter
- TMEM161A p.Leu13Phe Uncertain significance Single submitter
- TMEM161A p.Leu200Val Uncertain significance Single submitter
- TMEM161A p.Leu220Ile Uncertain significance Single submitter
- TMEM161A p.Leu278Gln Uncertain significance Single submitter
- TMEM161A p.Leu31Val Uncertain significance Single submitter
- TMEM161A p.Leu340Pro Uncertain significance Single submitter
- TMEM161A p.Leu348Gln Uncertain significance Single submitter
- TMEM161A p.Leu391Met Uncertain significance Single submitter
- TMEM161A p.Leu392Phe Uncertain significance Single submitter
- TMEM161A p.Leu407Ile Uncertain significance Single submitter
- TMEM161A p.Leu408Pro Uncertain significance Single submitter
- TMEM161A p.Leu442Phe Uncertain significance Single submitter
- TMEM161A p.Leu447Phe Uncertain significance Single submitter
- TMEM161A p.Phe82Tyr Uncertain significance Single submitter
- TMEM161A p.Pro264Arg Uncertain significance Single submitter
- TMEM161A p.Pro297Leu Uncertain significance Single submitter
- TMEM161A p.Pro406Ala Uncertain significance Single submitter
- TMEM161A p.Pro81Leu Uncertain significance Single submitter
- TMEM161A p.Ser260Leu Uncertain significance Single submitter
- TMEM161A p.Ser260Trp Uncertain significance Single submitter
- TMEM161A p.Ser273Thr Uncertain significance Single submitter
- TMEM161A p.Ser313Cys Uncertain significance Single submitter
- TMEM161A p.Ser313Phe Uncertain significance Single submitter
- TMEM161A p.Thr153Ile Uncertain significance Single submitter
- TMEM161A p.Thr155Ile Uncertain significance Single submitter
- TMEM161A p.Thr430Ala Uncertain significance Single submitter
- TMEM161A p.Trp317Leu Uncertain significance Single submitter
- TMEM161A p.Tyr124His Uncertain significance Single submitter
- TMEM161A p.Val169Ile Uncertain significance Single submitter
- TMEM161A p.Val229Leu Uncertain significance Single submitter
- TMEM161A p.Val229Met Uncertain significance Single submitter
- TMEM161A p.Val76Ala Uncertain significance Single submitter
- TMEM161A p.Val92Met Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- TMEM161A p.Arg188Trp Uncertain significance Single submitter
- TMEM161A p.Arg448Cys Uncertain significance Single submitter
- TMEM161A p.Gly164Arg Uncertain significance Single submitter
- TMEM161A p.Gly164Val Uncertain significance Single submitter
- TMEM161A p.Leu220Phe Uncertain significance Single submitter
- TMEM161A p.Pro55Leu Uncertain significance Single submitter
- TMEM161A p.Ser276Tyr Uncertain significance Single submitter
- TMEM161A p.Thr372Ile Uncertain significance Single submitter
- TMEM161A p.Thr90Met Uncertain significance Single submitter
- TMEM161A p.Trp30Cys Uncertain significance Single submitter
- TMEM161A p.Tyr370His Uncertain significance Single submitter
- TMEM161A p.Val116Met Uncertain significance Single submitter
- TMEM161A p.Val373Leu Uncertain significance Single submitter
All TMEM161A variants
Likely benign 2
- p.Arg433Gln Single submitter
- p.Glu190Asp Single submitter
Uncertain significance 76
- p.Ala161Ser Single submitter ⚠
- p.Ala161Thr Single submitter ⚠
- p.Ala250Thr Single submitter ⚠
- p.Ala357Val Single submitter ⚠
- p.Ala418Val Single submitter ⚠
- p.Ala437Ser Single submitter ⚠
- p.Ala52Val Single submitter ⚠
- p.Ala65Ser Single submitter ⚠
- p.Arg156Trp Single submitter ⚠
- p.Arg188Trp Single submitter ⚠
- p.Arg228Cys Single submitter ⚠
- p.Arg254Gln Single submitter ⚠
- p.Arg254Trp Single submitter ⚠
- p.Arg290Gln Single submitter ⚠
- p.Arg358His Single submitter ⚠
- p.Arg363Thr Single submitter ⚠
- p.Arg448Cys Single submitter ⚠
- p.Arg49Gln Single submitter ⚠
- p.Arg78Gln Single submitter ⚠
- p.Glu163Asp Single submitter ⚠
- p.Glu189Asp Single submitter ⚠
- p.Glu193Lys Single submitter ⚠
- p.Glu62Gly Single submitter ⚠
- p.Gly115Ser Single submitter ⚠
- p.Gly164Arg Single submitter ⚠
- p.Gly164Val Single submitter ⚠
- p.Gly403Asp Single submitter ⚠
- p.Gly421Cys Single submitter ⚠
- p.Gly423Arg Single submitter ⚠
- p.Ile227Leu Single submitter ⚠
- p.Ile288Thr Single submitter
- p.Ile455Thr Single submitter ⚠
- p.Leu13Phe Single submitter ⚠
- p.Leu200Val Single submitter ⚠
- p.Leu220Ile Single submitter ⚠
- p.Leu220Phe Single submitter ⚠
- p.Leu278Gln Single submitter ⚠
- p.Leu31Val Single submitter ⚠
- p.Leu340Pro Single submitter ⚠
- p.Leu348Gln Single submitter ⚠
- p.Leu391Met Single submitter ⚠
- p.Leu392Phe Single submitter ⚠
- p.Leu407Ile Single submitter ⚠
- p.Leu408Pro Single submitter ⚠
- p.Leu442Phe Single submitter ⚠
- p.Leu447Phe Single submitter ⚠
- p.Phe82Tyr Single submitter ⚠
- p.Pro264Arg Single submitter ⚠
- p.Pro297Leu Single submitter ⚠
- p.Pro406Ala Single submitter ⚠
- p.Pro55Leu Single submitter ⚠
- p.Pro81Leu Single submitter ⚠
- p.Ser260Leu Single submitter ⚠
- p.Ser260Trp Single submitter ⚠
- p.Ser273Thr Single submitter ⚠
- p.Ser276Tyr Single submitter ⚠
- p.Ser313Cys Single submitter ⚠
- p.Ser313Phe Single submitter ⚠
- p.Thr153Ile Single submitter ⚠
- p.Thr155Ile Single submitter ⚠
- p.Thr372Ile Single submitter ⚠
- p.Thr430Ala Single submitter ⚠
- p.Thr90Met Single submitter ⚠
- p.Trp30Cys Single submitter ⚠
- p.Trp30Gly Single submitter
- p.Trp317Leu Single submitter ⚠
- p.Tyr124His Single submitter ⚠
- p.Tyr370Cys Single submitter
- p.Tyr370His Single submitter ⚠
- p.Val116Met Single submitter ⚠
- p.Val169Ile Single submitter ⚠
- p.Val229Leu Single submitter ⚠
- p.Val229Met Single submitter ⚠
- p.Val373Leu Single submitter ⚠
- p.Val76Ala Single submitter ⚠
- p.Val92Met Single submitter ⚠