TMEM41B — 39 ClinVar variants
All ClinVar germline TMEM41B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
2 Likely benign · 37 Uncertain significance
Full TMEM41B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TMEM41B p.Ala116Val Uncertain significance Single submitter
- TMEM41B p.Ala148Val Uncertain significance Single submitter
- TMEM41B p.Ala238Val Uncertain significance Single submitter
- TMEM41B p.Ala32Val Uncertain significance Single submitter
- TMEM41B p.Arg192His Uncertain significance Single submitter
- TMEM41B p.Arg28Pro Uncertain significance Single submitter
- TMEM41B p.Arg5Gly Uncertain significance Single submitter
- TMEM41B p.Arg5Thr Uncertain significance Single submitter
- TMEM41B p.Asn85Ser Uncertain significance Single submitter
- TMEM41B p.Gln39Arg Uncertain significance Single submitter
- TMEM41B p.Glu82Asp Uncertain significance Single submitter
- TMEM41B p.His15Gln Uncertain significance Single submitter
- TMEM41B p.Ile129Val Uncertain significance Single submitter
- TMEM41B p.Ile133Val Uncertain significance Single submitter
- TMEM41B p.Ile217Val Uncertain significance Single submitter
- TMEM41B p.Ile56Met Uncertain significance Single submitter
- TMEM41B p.Leu12Ser Uncertain significance Single submitter
- TMEM41B p.Lys106Arg Uncertain significance Single submitter
- TMEM41B p.Lys106Asn Uncertain significance Single submitter
- TMEM41B p.Met165Val Uncertain significance Single submitter
- TMEM41B p.Pro239Ala Uncertain significance Single submitter
- TMEM41B p.Pro240Ser Uncertain significance Single submitter
- TMEM41B p.Ser103Phe Uncertain significance Single submitter
- TMEM41B p.Ser35Gly Uncertain significance Single submitter
- TMEM41B p.Ser35Ile Uncertain significance Single submitter
- TMEM41B p.Ser43Phe Uncertain significance Single submitter
- TMEM41B p.Thr18Asn Uncertain significance Single submitter
- TMEM41B p.Thr27Arg Uncertain significance Single submitter
- TMEM41B p.Val115Ala Uncertain significance Single submitter
- TMEM41B p.Val184Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- TMEM41B p.Ala116Thr Uncertain significance Single submitter
- TMEM41B p.Asp91Gly Uncertain significance Single submitter
- TMEM41B p.Ile137Val Uncertain significance Single submitter
- TMEM41B p.Ile60Ser Uncertain significance Single submitter
- TMEM41B p.Leu179Gln Uncertain significance Single submitter
- TMEM41B p.Leu204Phe Uncertain significance Single submitter
All TMEM41B variants
Likely benign 2
- p.Gly26Glu Single submitter
- p.Trp44Cys Single submitter
Uncertain significance 37
- p.Ala116Thr Single submitter ⚠
- p.Ala116Val Single submitter ⚠
- p.Ala148Val Single submitter ⚠
- p.Ala238Val Single submitter ⚠
- p.Ala32Val Single submitter ⚠
- p.Arg192His Single submitter ⚠
- p.Arg28Pro Single submitter ⚠
- p.Arg5Gly Single submitter ⚠
- p.Arg5Thr Single submitter ⚠
- p.Asn85Ser Single submitter ⚠
- p.Asp91Gly Single submitter ⚠
- p.Gln39Arg Single submitter ⚠
- p.Glu82Asp Single submitter ⚠
- p.His15Gln Single submitter ⚠
- p.Ile129Val Single submitter ⚠
- p.Ile133Val Single submitter ⚠
- p.Ile137Val Single submitter ⚠
- p.Ile217Val Single submitter ⚠
- p.Ile56Met Single submitter ⚠
- p.Ile60Ser Single submitter ⚠
- p.Leu12Ser Single submitter ⚠
- p.Leu179Gln Single submitter ⚠
- p.Leu204Phe Single submitter ⚠
- p.Lys106Arg Single submitter ⚠
- p.Lys106Asn Single submitter ⚠
- p.Met165Val Single submitter ⚠
- p.Pro239Ala Single submitter ⚠
- p.Pro240Ser Single submitter ⚠
- p.Ser103Phe Single submitter ⚠
- p.Ser35Gly Single submitter ⚠
- p.Ser35Ile Single submitter ⚠
- p.Ser43Phe Single submitter ⚠
- p.Thr18Asn Single submitter ⚠
- p.Thr255Arg Single submitter
- p.Thr27Arg Single submitter ⚠
- p.Val115Ala Single submitter ⚠
- p.Val184Ile Single submitter ⚠