Sugi Variant

Sugi Variant/TMPO

TMPO — 830 ClinVar variants

All ClinVar germline TMPO variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 446 flagged for review →

31 Conflicting · 40 Benign · 18 Benign/Likely benign · 236 Likely benign · 505 Uncertain significance

Full TMPO gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 446

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 25

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 367

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 367

Predictors split 54

The independent predictors disagree with each other — read with care.

All TMPO variants

Conflicting classifications of pathogenicity 31

Benign 40

Benign/Likely benign 18

Likely benign 236

Uncertain significance 505

Showing the top 300 by review status; the full set is in the sitemap.