TNK1 — 111 ClinVar variants
All ClinVar germline TNK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 87 flagged for review →
12 Benign · 12 Likely benign · 87 Uncertain significance
Full TNK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 87
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 67
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TNK1 p.Ala220Val Uncertain significance Single submitter
- TNK1 p.Ala361Pro Uncertain significance Single submitter
- TNK1 p.Ala396Ser Uncertain significance Single submitter
- TNK1 p.Ala396Val Uncertain significance Single submitter
- TNK1 p.Arg15Gln Uncertain significance Single submitter
- TNK1 p.Arg15Trp Uncertain significance Single submitter
- TNK1 p.Arg207His Uncertain significance Single submitter
- TNK1 p.Arg389Lys Uncertain significance Single submitter
- TNK1 p.Arg447Cys Uncertain significance Single submitter
- TNK1 p.Arg447His Uncertain significance Single submitter
- TNK1 p.Arg456Trp Uncertain significance Single submitter
- TNK1 p.Arg480Leu Uncertain significance Single submitter
- TNK1 p.Arg496Thr Uncertain significance Single submitter
- TNK1 p.Arg507His Uncertain significance Single submitter
- TNK1 p.Arg519Gln Uncertain significance Single submitter
- TNK1 p.Arg571His Uncertain significance Single submitter
- TNK1 p.Arg634Trp Uncertain significance Single submitter
- TNK1 p.Arg641His Uncertain significance Single submitter
- TNK1 p.Arg641Ser Uncertain significance Single submitter
- TNK1 p.Arg655Cys Uncertain significance Single submitter
- TNK1 p.Arg655His Uncertain significance Single submitter
- TNK1 p.Arg660Lys Uncertain significance Single submitter
- TNK1 p.Asn31His Uncertain significance Single submitter
- TNK1 p.Asn74Asp Uncertain significance Single submitter
- TNK1 p.Asp39Asn Uncertain significance Single submitter
- TNK1 p.Asp413Glu Uncertain significance Single submitter
- TNK1 p.Asp465Asn Uncertain significance Single submitter
- TNK1 p.Asp475Val Uncertain significance Single submitter
- TNK1 p.Gln606His Uncertain significance Single submitter
- TNK1 p.Gln627Lys Uncertain significance Single submitter
- TNK1 p.Glu104Asp Uncertain significance Single submitter
- TNK1 p.Gly125Ala Uncertain significance Single submitter
- TNK1 p.Gly381Arg Uncertain significance Single submitter
- TNK1 p.Gly442Ala Uncertain significance Single submitter
- TNK1 p.Gly457Arg Uncertain significance Single submitter
- TNK1 p.Gly505Ser Uncertain significance Single submitter
- TNK1 p.Gly512Val Uncertain significance Single submitter
- TNK1 p.Gly599Glu Uncertain significance Single submitter
- TNK1 p.Gly69Val Uncertain significance Single submitter
- TNK1 p.His563Gln Uncertain significance Single submitter
- TNK1 p.Ile464Met Uncertain significance Single submitter
- TNK1 p.Leu221Val Uncertain significance Single submitter
- TNK1 p.Leu377Pro Uncertain significance Single submitter
- TNK1 p.Leu580Phe Uncertain significance Single submitter
- TNK1 p.Leu609Arg Uncertain significance Single submitter
- TNK1 p.Leu631Pro Uncertain significance Single submitter
- TNK1 p.Lys469Arg Uncertain significance Single submitter
- TNK1 p.Pro101Arg Uncertain significance Single submitter
- TNK1 p.Pro101Leu Uncertain significance Single submitter
- TNK1 p.Pro154Ser Uncertain significance Single submitter
- TNK1 p.Pro178Ser Uncertain significance Single submitter
- TNK1 p.Pro215Ser Uncertain significance Single submitter
- TNK1 p.Pro329Ser Uncertain significance Single submitter
- TNK1 p.Pro346Leu Uncertain significance Single submitter
- TNK1 p.Pro362Leu Uncertain significance Single submitter
- TNK1 p.Pro43Ala Uncertain significance Single submitter
- TNK1 p.Pro487Leu Uncertain significance Single submitter
- TNK1 p.Pro528His Uncertain significance Single submitter
- TNK1 p.Pro535Ser Uncertain significance Single submitter
- TNK1 p.Ser142Asn Uncertain significance Single submitter
- TNK1 p.Ser294Asn Uncertain significance Single submitter
- TNK1 p.Ser294Ile Uncertain significance Single submitter
- TNK1 p.Ser383Leu Uncertain significance Single submitter
- TNK1 p.Ser632Gly Uncertain significance Single submitter
- TNK1 p.Thr209Lys Uncertain significance Single submitter
- TNK1 p.Thr436Met Uncertain significance Single submitter
- TNK1 p.Val449Leu Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- TNK1 p.Leu357Phe Uncertain significance Multiple submitters
- TNK1 p.Arg15Pro Uncertain significance Single submitter
- TNK1 p.Arg182His Uncertain significance Single submitter
- TNK1 p.Arg227Trp Uncertain significance Single submitter
- TNK1 p.Arg344Thr Uncertain significance Single submitter
- TNK1 p.Arg423Cys Uncertain significance Single submitter
- TNK1 p.Arg53Trp Uncertain significance Single submitter
- TNK1 p.Arg57Cys Uncertain significance Single submitter
- TNK1 p.His179Tyr Uncertain significance Single submitter
- TNK1 p.Leu192Pro Uncertain significance Single submitter
- TNK1 p.Phe225Leu Uncertain significance Single submitter
- TNK1 p.Phe38Leu Uncertain significance Single submitter
- TNK1 p.Pro364Leu Uncertain significance Single submitter
- TNK1 p.Pro584Ser Uncertain significance Single submitter
- TNK1 p.Thr136Met Uncertain significance Single submitter
- TNK1 p.Thr33Ala Uncertain significance Single submitter
- TNK1 p.Thr33Ile Uncertain significance Single submitter
- TNK1 p.Trp135Cys Uncertain significance Single submitter
- TNK1 p.His131Gln Uncertain significance No assertion criteria
-
TNK1 p.Val593Met
Benign
No assertion criteria
TNK1-related disorder
All TNK1 variants
Benign 12
- p.Asn421= Single submitter
- p.Gly566Arg Single submitter
- p.Ser433= Single submitter
- p.Tyr353= Single submitter
- c.1398-2A>G No assertion criteria TNK1-related disorder
- p.Arg456Gln No assertion criteria TNK1-related disorder
- p.Gly395= No assertion criteria TNK1-related disorder
- p.Leu27= No assertion criteria TNK1-related disorder
- p.Pro478= No assertion criteria TNK1-related disorder
- p.Ser541Cys No assertion criteria TNK1-related disorder
- p.Ser7= No assertion criteria TNK1-related disorder
- p.Val593Met No assertion criteria TNK1-related disorder ⚠
Likely benign 12
- p.Ala476Val Single submitter
- p.Ala574Thr Single submitter
- p.Gly48Ser Single submitter
- p.His297Gln Single submitter
- p.His372Tyr Single submitter
- p.Pro661Ser Single submitter
- c.427-9del No assertion criteria TNK1-related disorder
- p.Ala212= No assertion criteria TNK1-related disorder
- p.Ala299Asp No assertion criteria TNK1-related disorder
- p.Asp47= No assertion criteria TNK1-related disorder
- p.Ser383= No assertion criteria TNK1-related disorder
- p.Ser582= No assertion criteria TNK1-related disorder
Uncertain significance 87
- p.Leu357Phe Multiple submitters ⚠
- p.Ala220Val Single submitter ⚠
- p.Ala361Pro Single submitter ⚠
- p.Ala396Ser Single submitter ⚠
- p.Ala396Val Single submitter ⚠
- p.Arg15Gln Single submitter ⚠
- p.Arg15Pro Single submitter ⚠
- p.Arg15Trp Single submitter ⚠
- p.Arg182His Single submitter ⚠
- p.Arg207His Single submitter ⚠
- p.Arg227Trp Single submitter ⚠
- p.Arg344Thr Single submitter ⚠
- p.Arg389Lys Single submitter ⚠
- p.Arg423Cys Single submitter ⚠
- p.Arg447Cys Single submitter ⚠
- p.Arg447His Single submitter ⚠
- p.Arg456Trp Single submitter ⚠
- p.Arg480Leu Single submitter ⚠
- p.Arg496Thr Single submitter ⚠
- p.Arg507His Single submitter ⚠
- p.Arg519Gln Single submitter ⚠
- p.Arg53Trp Single submitter ⚠
- p.Arg571His Single submitter ⚠
- p.Arg57Cys Single submitter ⚠
- p.Arg634Trp Single submitter ⚠
- p.Arg641His Single submitter ⚠
- p.Arg641Ser Single submitter ⚠
- p.Arg655Cys Single submitter ⚠
- p.Arg655His Single submitter ⚠
- p.Arg660Lys Single submitter ⚠
- p.Asn31His Single submitter ⚠
- p.Asn74Asp Single submitter ⚠
- p.Asp39Asn Single submitter ⚠
- p.Asp413Glu Single submitter ⚠
- p.Asp465Asn Single submitter ⚠
- p.Asp475Val Single submitter ⚠
- p.Gln606His Single submitter ⚠
- p.Gln627Lys Single submitter ⚠
- p.Glu104Asp Single submitter ⚠
- p.Gly125Ala Single submitter ⚠
- p.Gly381Arg Single submitter ⚠
- p.Gly442Ala Single submitter ⚠
- p.Gly457Arg Single submitter ⚠
- p.Gly505Ser Single submitter ⚠
- p.Gly512Val Single submitter ⚠
- p.Gly599Glu Single submitter ⚠
- p.Gly69Val Single submitter ⚠
- p.His179Tyr Single submitter ⚠
- p.His563Gln Single submitter ⚠
- p.Ile464Met Single submitter ⚠
- p.Leu192Pro Single submitter ⚠
- p.Leu221Val Single submitter ⚠
- p.Leu377Pro Single submitter ⚠
- p.Leu580Phe Single submitter ⚠
- p.Leu609Arg Single submitter ⚠
- p.Leu631Pro Single submitter ⚠
- p.Lys469Arg Single submitter ⚠
- p.Phe225Leu Single submitter ⚠
- p.Phe38Leu Single submitter ⚠
- p.Pro101Arg Single submitter ⚠
- p.Pro101Leu Single submitter ⚠
- p.Pro154Ser Single submitter ⚠
- p.Pro178Ser Single submitter ⚠
- p.Pro191Ala Single submitter
- p.Pro215Ser Single submitter ⚠
- p.Pro329Ser Single submitter ⚠
- p.Pro346Leu Single submitter ⚠
- p.Pro362Leu Single submitter ⚠
- p.Pro364Leu Single submitter ⚠
- p.Pro43Ala Single submitter ⚠
- p.Pro487Leu Single submitter ⚠
- p.Pro528His Single submitter ⚠
- p.Pro535Ser Single submitter ⚠
- p.Pro584Ser Single submitter ⚠
- p.Ser142Asn Single submitter ⚠
- p.Ser294Asn Single submitter ⚠
- p.Ser294Ile Single submitter ⚠
- p.Ser383Leu Single submitter ⚠
- p.Ser632Gly Single submitter ⚠
- p.Thr136Met Single submitter ⚠
- p.Thr209Lys Single submitter ⚠
- p.Thr33Ala Single submitter ⚠
- p.Thr33Ile Single submitter ⚠
- p.Thr436Met Single submitter ⚠
- p.Trp135Cys Single submitter ⚠
- p.Val449Leu Single submitter ⚠
- p.His131Gln No assertion criteria ⚠