TNNC1 — 380 ClinVar variants

All ClinVar germline TNNC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 156 flagged for review →

5 Pathogenic · 6 Likely pathogenic · 27 Conflicting · 6 Benign · 7 Benign/Likely benign · 123 Likely benign · 206 Uncertain significance

Full TNNC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 156

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 2

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

TNNC1 p.Ala31Ser Pathogenic Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Ile4Met Pathogenic No assertion criteria
dilated cardiomyopathy 1Z

Predictors agree, ClinVar conflicts 5

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

TNNC1 p.Asn144Asp Conflicting Single submitter
TNNC1-related disorder
TNNC1 p.Asp88Asn Conflicting Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Glu134Lys Conflicting Single submitter
TNNC1-related disorder
TNNC1 p.Met45Ile Conflicting Single submitter
Cardiovascular phenotype
TNNC1 p.Pro52Arg Conflicting Single submitter
Cardiovascular phenotype

Predictors lean, ClinVar uncertain 95

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

TNNC1 p.Ala22Ser Uncertain significance Multiple submitters
dilated cardiomyopathy 1Z
TNNC1 p.Ala31Thr Uncertain significance Multiple submitters
dilated cardiomyopathy 1Z
TNNC1 p.Arg102His Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Arg147His Uncertain significance Multiple submitters
dilated cardiomyopathy 1Z
TNNC1 p.Arg83Gln Uncertain significance Multiple submitters
dilated cardiomyopathy 1Z
TNNC1 p.Asn107Lys Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Asn18Thr Uncertain significance Multiple submitters
hypertrophic cardiomyopathy 13
TNNC1 p.Asp105His Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Asp131Glu Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Asp145Asn Uncertain significance Multiple submitters
dilated cardiomyopathy 1Z
TNNC1 p.Asp145Glu Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Asp145His Uncertain significance Multiple submitters
dilated cardiomyopathy 1Z
TNNC1 p.Asp25Asn Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Asp2Asn Uncertain significance Multiple submitters
dilated cardiomyopathy 1Z
TNNC1 p.Asp2Gly Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Asp62Asn Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Asp75Glu Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Glu126Lys Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Glu134Asp Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Glu95Asp Uncertain significance Multiple submitters
dilated cardiomyopathy 1Z
TNNC1 p.Gly140Arg Uncertain significance Multiple submitters
dilated cardiomyopathy 1Z
TNNC1 p.Gly140Glu Uncertain significance Multiple submitters
hypertrophic cardiomyopathy 13
TNNC1 p.Gly70Ser Uncertain significance Multiple submitters
dilated cardiomyopathy 1Z
TNNC1 p.Ile112Val Uncertain significance Multiple submitters
dilated cardiomyopathy 1Z
TNNC1 p.Ile119Thr Uncertain significance Multiple submitters
dilated cardiomyopathy 1Z
TNNC1 p.Ile148Val Uncertain significance Multiple submitters
hypertrophic cardiomyopathy 13
TNNC1 p.Leu114Arg Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Leu29Gln Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Lys17Glu Uncertain significance Multiple submitters
hypertrophic cardiomyopathy 13
TNNC1 p.Lys39Arg Uncertain significance Multiple submitters
hypertrophic cardiomyopathy 13
TNNC1 p.Lys6Arg Uncertain significance Multiple submitters
dilated cardiomyopathy 1Z
TNNC1 p.Lys92Arg Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Met103Leu Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Met120Val Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Met60Ile Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Met81Ile Uncertain significance Multiple submitters
hypertrophic cardiomyopathy 13
TNNC1 p.Met81Thr Uncertain significance Multiple submitters
dilated cardiomyopathy 1Z
TNNC1 p.Phe74Cys Uncertain significance Multiple submitters
dilated cardiomyopathy 1Z
TNNC1 p.Thr124Pro Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Thr129Arg Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Thr71Met Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Val44Met Uncertain significance Multiple submitters
hypertrophic cardiomyopathy 13
TNNC1 p.Val9Ile Uncertain significance Multiple submitters
hypertrophic cardiomyopathy 13
TNNC1 p.Ala23Asp Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Ala23Gly Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Arg83Gly Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Arg83Trp Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Asn143Lys Uncertain significance Single submitter
hypertrophic cardiomyopathy 13
TNNC1 p.Asn144Ser Uncertain significance Single submitter
TNNC1 p.Asn18Ser Uncertain significance Single submitter
Cardiovascular phenotype
TNNC1 p.Asn51Lys Uncertain significance Single submitter
TNNC1 p.Asp105Gly Uncertain significance Single submitter
hypertrophic cardiomyopathy 13
TNNC1 p.Asp109Val Uncertain significance Single submitter
hypertrophic cardiomyopathy 13
TNNC1 p.Asp145Val Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Asp149Gly Uncertain significance Single submitter
TNNC1 p.Asp3Asn Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Asp62Tyr Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Asp65Glu Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Asp75Asn Uncertain significance Single submitter
Cardiovascular phenotype
TNNC1 p.Asp88Tyr Uncertain significance Single submitter
TNNC1 p.Gln16Arg Uncertain significance Single submitter
TNNC1 p.Glu135Asp Uncertain significance Single submitter
TNNC1-related disorder
TNNC1 p.Glu15Asp Uncertain significance Single submitter
hypertrophic cardiomyopathy 13
TNNC1 p.Glu161Asp Uncertain significance Single submitter
hypertrophic cardiomyopathy 13
TNNC1 p.Glu55Lys Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Glu96Gly Uncertain significance Single submitter
TNNC1 p.Gly110Cys Uncertain significance Single submitter
hypertrophic cardiomyopathy 13
TNNC1 p.Gly146Cys Uncertain significance Single submitter
hypertrophic cardiomyopathy 13
TNNC1 p.Gly159Ser Uncertain significance Single submitter
TNNC1 p.Gly42Asp Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Ile112Met Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Ile119Val Uncertain significance Single submitter
hypertrophic cardiomyopathy 13
TNNC1 p.Ile133Met Uncertain significance Single submitter
hypertrophic cardiomyopathy 13
TNNC1 p.Ile133Val Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Ile4Thr Uncertain significance Single submitter
TNNC1 p.Leu41Met Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Lys138Glu Uncertain significance Single submitter
Cardiovascular phenotype
TNNC1 p.Lys158Arg Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Lys17Thr Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Lys6Gln Uncertain significance Single submitter
hypertrophic cardiomyopathy 13
TNNC1 p.Met103Val Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Met45Val Uncertain significance Single submitter
hypertrophic cardiomyopathy 13
TNNC1 p.Met85Leu Uncertain significance Single submitter
Cardiovascular phenotype
TNNC1 p.Pro52Leu Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Pro52Ser Uncertain significance Single submitter
Cardiovascular phenotype
TNNC1 p.Ser69Arg Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Ser89Gly Uncertain significance Single submitter
hypertrophic cardiomyopathy 13
TNNC1 p.Ser93Pro Uncertain significance Single submitter
TNNC1 p.Ser98Cys Uncertain significance Single submitter
Cardiovascular phenotype
TNNC1 p.Thr127Ala Uncertain significance Single submitter
Cardiovascular phenotype
TNNC1 p.Thr53Asn Uncertain significance Single submitter
Cardiovascular phenotype
TNNC1 p.Thr53Ile Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Val28Met Uncertain significance Single submitter
Cardiovascular phenotype
TNNC1 p.Val64Ala Uncertain significance Single submitter
TNNC1 p.Val72Ala Uncertain significance Single submitter
dilated cardiomyopathy 1Z

Predictors split 54

The independent predictors disagree with each other — read with care.

TNNC1 p.Ala22Val Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Arg102Leu Uncertain significance Multiple submitters
dilated cardiomyopathy 1Z
TNNC1 p.Arg147Cys Uncertain significance Multiple submitters
cardiomyopathy
TNNC1 p.Asp132Asn Uncertain significance Multiple submitters
dilated cardiomyopathy 1Z
TNNC1 p.Glu135Ala Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Glu152Asp Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Glu32Lys Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Glu63Asp Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Glu94Gln Uncertain significance Multiple submitters
dilated cardiomyopathy 1Z
TNNC1 p.Gly146Ser Uncertain significance Multiple submitters
hypertrophic cardiomyopathy 13
TNNC1 p.Lys92Ile Uncertain significance Multiple submitters
dilated cardiomyopathy 1Z
TNNC1 p.Met157Ile Uncertain significance Multiple submitters
Cardiovascular phenotype
TNNC1 p.Met47Arg Uncertain significance Multiple submitters
dilated cardiomyopathy 1Z
TNNC1 p.Met81Leu Uncertain significance Multiple submitters
hypertrophic cardiomyopathy 13
TNNC1 p.Thr129Met Uncertain significance Multiple submitters
hypertrophic cardiomyopathy 13
TNNC1 p.Ala22Glu Uncertain significance Single submitter
hypertrophic cardiomyopathy 13
TNNC1 p.Ala8Val Conflicting Single submitter
Cardiovascular phenotype
TNNC1 p.Arg102Ser Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Arg147Ser Uncertain significance Single submitter
hypertrophic cardiomyopathy 13
TNNC1 p.Arg46Lys Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Asp113Glu Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Asp139Ala Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Asp139Gly Uncertain significance Single submitter
Cardiovascular phenotype
TNNC1 p.Asp151Tyr Uncertain significance Single submitter
hypertrophic cardiomyopathy 13
TNNC1 p.Asp151Val Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Asp2Val Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Asp33Asn Uncertain significance Single submitter
TNNC1 p.Asp62His Uncertain significance Single submitter
hypertrophic cardiomyopathy 13
TNNC1 p.Cys84Tyr Conflicting Single submitter
TNNC1-related disorder
TNNC1 p.Gln16Glu Uncertain significance Single submitter
TNNC1 p.Gln50His Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Glu116Asp Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Glu19Asp Uncertain significance Single submitter
Cardiovascular phenotype
TNNC1 p.Glu56Asp Likely pathogenic Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Glu63Ala Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Gly146Arg Uncertain significance Single submitter
hypertrophic cardiomyopathy 13
TNNC1 p.Gly159Asp Likely pathogenic Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Gly91Arg Uncertain significance Single submitter
hypertrophic cardiomyopathy 13
TNNC1 p.Ile128Asn Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Ile128Thr Uncertain significance Single submitter
hypertrophic cardiomyopathy 13
TNNC1 p.Leu100Phe Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Lys118Asn Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Lys142Asn Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Lys86Thr Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Met103Ile Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Met157Arg Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Met157Val Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Met47Ile Likely pathogenic Single submitter
TNNC1 p.Met47Val Uncertain significance Single submitter
hypertrophic cardiomyopathy 13
TNNC1 p.Phe104Val Uncertain significance Single submitter
TNNC1 p.Ser37Gly Uncertain significance Single submitter
TNNC1 p.Tyr111Cys Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Tyr111His Uncertain significance Single submitter
dilated cardiomyopathy 1Z
TNNC1 p.Gly34Arg Pathogenic No assertion criteria
dilated cardiomyopathy 1Z

All TNNC1 variants

Pathogenic 5

p.Ala31Ser Single submitter dilated cardiomyopathy 1Z ⚠
c.317+1G>A No assertion criteria
p.Glu152Lys No assertion criteria dilated cardiomyopathy 1Z
p.Gly34Arg No assertion criteria dilated cardiomyopathy 1Z ⚠
p.Ile4Met No assertion criteria dilated cardiomyopathy 1Z ⚠

Likely pathogenic 6

p.Asp149Tyr Single submitter TNNC1-related disorder
p.Asp3Val Single submitter
p.Glu56Asp Single submitter dilated cardiomyopathy 1Z ⚠
p.Gly159Asp Single submitter dilated cardiomyopathy 1Z ⚠
p.Leu97Gln Single submitter
p.Met47Ile Single submitter ⚠

Conflicting classifications of pathogenicity 27

c.203-10C>G Single submitter dilated cardiomyopathy 1Z
c.24+6G>A Single submitter dilated cardiomyopathy 1Z
c.318-9T>A Single submitter hypertrophic cardiomyopathy 13
c.454+6C>T Single submitter hypertrophic cardiomyopathy 13
c.454+7G>A Single submitter cardiomyopathy
c.455-6C>G Single submitter dilated cardiomyopathy 1Z
c.55+9C>A Single submitter dilated cardiomyopathy 1Z
c.56-8G>A Single submitter dilated cardiomyopathy 1Z
c.-6G>A Single submitter
c.-7C>T Single submitter
c.*127C>T Single submitter dilated cardiomyopathy 1Z
p.Ala8Val Single submitter Cardiovascular phenotype ⚠
p.Asn144Asp Single submitter TNNC1-related disorder ⚠
p.Asp149Asn Single submitter Cardiovascular phenotype
p.Asp65= Single submitter dilated cardiomyopathy 1Z
p.Asp88Asn Single submitter dilated cardiomyopathy 1Z ⚠
p.Cys84Tyr Single submitter TNNC1-related disorder ⚠
p.Glu134Lys Single submitter TNNC1-related disorder ⚠
p.Gly70= Single submitter Cardiovascular phenotype
p.Ile36= Single submitter Cardiovascular phenotype
p.Met45Ile Single submitter Cardiovascular phenotype ⚠
p.Phe27= Single submitter Cardiovascular phenotype
p.Pro52Arg Single submitter Cardiovascular phenotype ⚠
p.Pro54His Single submitter
p.Thr129= Single submitter Cardiovascular phenotype
p.Tyr5Cys Single submitter hypertrophic cardiomyopathy 13
p.Val72= Single submitter hypertrophic cardiomyopathy 13

Benign 6

c.-171G>A Multiple submitters
c.455-14C>A Single submitter
c.56-16del Single submitter hypertrophic cardiomyopathy 13
c.56-16dup Single submitter dilated cardiomyopathy 1Z
c.*123G>A Single submitter
c.*77G>T Single submitter

Benign/Likely benign 7

c.203-5C>T Multiple submitters Cardiovascular phenotype
c.317+8C>T Multiple submitters dilated cardiomyopathy 1Z
c.317+9G>A Multiple submitters hypertrophic cardiomyopathy 13
c.*83A>C Multiple submitters dilated cardiomyopathy 1Z
p.Ala108= Multiple submitters Cardiovascular phenotype
p.Asp67= Multiple submitters Cardiovascular phenotype
p.Ser69= Multiple submitters Cardiovascular phenotype

Likely benign 123

c.203-14C>T Multiple submitters dilated cardiomyopathy 1Z
c.203-16T>C Multiple submitters dilated cardiomyopathy 1Z
c.24+10A>G Multiple submitters dilated cardiomyopathy 1Z
c.24+13G>T Multiple submitters hypertrophic cardiomyopathy 13
c.454+17G>A Multiple submitters dilated cardiomyopathy 1Z
c.55+20_55+21del Multiple submitters hypertrophic cardiomyopathy 13
c.56-9T>C Multiple submitters hypertrophic cardiomyopathy 13
p.Ala31= Multiple submitters Cardiovascular phenotype
p.Asn144= Multiple submitters Cardiovascular phenotype
p.Asp109= Multiple submitters Cardiovascular phenotype
p.Asp131= Multiple submitters hypertrophic cardiomyopathy 13
p.Asp139= Multiple submitters hypertrophic cardiomyopathy 13
p.Asp145= Multiple submitters dilated cardiomyopathy 1Z
p.Asp87= Multiple submitters Cardiovascular phenotype
p.Cys35= Multiple submitters Cardiovascular phenotype
p.Glu152= Multiple submitters Cardiovascular phenotype
p.Glu56= Multiple submitters dilated cardiomyopathy 1Z
p.Glu96= Multiple submitters dilated cardiomyopathy 1Z
p.Gly30= Multiple submitters dilated cardiomyopathy 1Z
p.Gly34= Multiple submitters dilated cardiomyopathy 1Z
p.Gly49= Multiple submitters hypertrophic cardiomyopathy 13
p.Ile112= Multiple submitters Cardiovascular phenotype
p.Ile128= Multiple submitters cardiomyopathy
p.Ile148= Multiple submitters Cardiovascular phenotype
p.Ile61= Multiple submitters Cardiovascular phenotype
p.Leu121= Multiple submitters Cardiovascular phenotype
p.Leu97= Multiple submitters Cardiovascular phenotype
p.Lys158= Multiple submitters Cardiovascular phenotype
p.Lys6= Multiple submitters dilated cardiomyopathy 1Z
p.Phe24= Multiple submitters Cardiovascular phenotype
p.Phe74= Multiple submitters Cardiovascular phenotype
p.Thr124= Multiple submitters dilated cardiomyopathy 1Z
p.Thr71= Multiple submitters Cardiovascular phenotype
p.Val160= Multiple submitters dilated cardiomyopathy 1Z
c.202+10C>G Single submitter dilated cardiomyopathy 1Z
c.202+10C>T Single submitter hypertrophic cardiomyopathy 13
c.202+12C>T Single submitter hypertrophic cardiomyopathy 13
c.202+13C>T Single submitter hypertrophic cardiomyopathy 13
c.202+16C>G Single submitter dilated cardiomyopathy 1Z
c.202+19A>G Single submitter dilated cardiomyopathy 1Z
c.202+20G>A Single submitter dilated cardiomyopathy 1Z
c.202+8C>A Single submitter dilated cardiomyopathy 1Z
c.203-13dup Single submitter dilated cardiomyopathy 1Z
c.203-17A>G Single submitter dilated cardiomyopathy 1Z
c.203-7C>A Single submitter dilated cardiomyopathy 1Z
c.203-7C>T Single submitter dilated cardiomyopathy 1Z
c.203-8A>G Single submitter dilated cardiomyopathy 1Z
c.203-9C>G Single submitter hypertrophic cardiomyopathy 13
c.24+17G>A Single submitter dilated cardiomyopathy 1Z
c.24+18G>A Single submitter dilated cardiomyopathy 1Z
c.24+19T>C Single submitter dilated cardiomyopathy 1Z
c.24+9C>G Single submitter dilated cardiomyopathy 1Z
c.24+9C>T Single submitter dilated cardiomyopathy 1Z
c.25-13C>G Single submitter hypertrophic cardiomyopathy 13
c.25-13C>T Single submitter hypertrophic cardiomyopathy 13
c.25-14C>T Single submitter hypertrophic cardiomyopathy 13
c.25-19G>A Single submitter dilated cardiomyopathy 1Z
c.25-9C>A Single submitter dilated cardiomyopathy 1Z
c.317+16T>C Single submitter dilated cardiomyopathy 1Z
c.317+18G>A Single submitter dilated cardiomyopathy 1Z
c.317+7A>G Single submitter dilated cardiomyopathy 1Z
c.317+9G>T Single submitter hypertrophic cardiomyopathy 13
c.318-10C>T Single submitter dilated cardiomyopathy 1Z
c.318-14C>A Single submitter dilated cardiomyopathy 1Z
c.318-17G>A Single submitter dilated cardiomyopathy 1Z
c.318-19C>T Single submitter hypertrophic cardiomyopathy 13
c.318-20C>T Single submitter hypertrophic cardiomyopathy 13
c.318-7C>T Single submitter dilated cardiomyopathy 1Z
c.454+15G>A Single submitter dilated cardiomyopathy 1Z
c.454+17G>C Single submitter hypertrophic cardiomyopathy 13
c.454+18C>T Single submitter dilated cardiomyopathy 1Z
c.454+6dup Single submitter dilated cardiomyopathy 1Z
c.454+8G>C Single submitter hypertrophic cardiomyopathy 13
c.455-18C>T Single submitter hypertrophic cardiomyopathy 13
c.455-19C>A Single submitter dilated cardiomyopathy 1Z
c.455-5C>T Single submitter hypertrophic cardiomyopathy 13
c.455-7T>C Single submitter hypertrophic cardiomyopathy 13
c.55+17C>T Single submitter dilated cardiomyopathy 1Z
c.55+20A>G Single submitter hypertrophic cardiomyopathy 13
c.56-10C>T Single submitter hypertrophic cardiomyopathy 13
c.56-12C>T Single submitter hypertrophic cardiomyopathy 13
c.56-13C>T Single submitter dilated cardiomyopathy 1Z
c.56-14A>C Single submitter dilated cardiomyopathy 1Z
c.56-16C>T Single submitter dilated cardiomyopathy 1Z
c.56-17C>T Single submitter dilated cardiomyopathy 1Z
c.56-18C>T Single submitter
p.Ala123= Single submitter dilated cardiomyopathy 1Z
p.Ala22= Single submitter Cardiovascular phenotype
p.Arg147= Single submitter Cardiovascular phenotype
p.Arg46= Single submitter Cardiovascular phenotype
p.Arg83= Single submitter hypertrophic cardiomyopathy 13
p.Asp132= Single submitter dilated cardiomyopathy 1Z
p.Asp25= Single submitter dilated cardiomyopathy 1Z
p.Asp3= Single submitter dilated cardiomyopathy 1Z
p.Asp62= Single submitter Cardiovascular phenotype
p.Asp73= Single submitter dilated cardiomyopathy 1Z
p.Asp75= Single submitter dilated cardiomyopathy 1Z
p.Asp88= Single submitter hypertrophic cardiomyopathy 13
p.Cys84= Single submitter hypertrophic cardiomyopathy 13
p.Glu10= Single submitter dilated cardiomyopathy 1Z
p.Glu130= Single submitter dilated cardiomyopathy 1Z
p.Glu134= Single submitter Cardiovascular phenotype
p.Glu15= Single submitter dilated cardiomyopathy 1Z
p.Glu161= Single submitter hypertrophic cardiomyopathy 13
p.Glu40= Single submitter dilated cardiomyopathy 1Z
p.Glu55= Single submitter dilated cardiomyopathy 1Z
p.Glu59= Single submitter hypertrophic cardiomyopathy 13
p.Gly110= Single submitter hypertrophic cardiomyopathy 13
p.Gly125= Single submitter hypertrophic cardiomyopathy 13
p.Ile133= Single submitter hypertrophic cardiomyopathy 13
p.Leu100= Single submitter Cardiovascular phenotype
p.Leu117= Single submitter dilated cardiomyopathy 1Z
p.Leu136= Single submitter dilated cardiomyopathy 1Z
p.Leu41= Single submitter Cardiovascular phenotype
p.Leu57= Single submitter hypertrophic cardiomyopathy 13
p.Lys118= Single submitter dilated cardiomyopathy 1Z
p.Lys17= Single submitter dilated cardiomyopathy 1Z
p.Lys90= Single submitter hypertrophic cardiomyopathy 13
p.Lys92= Single submitter cardiomyopathy
p.Pro52= Single submitter Cardiovascular phenotype
p.Pro54= Single submitter hypertrophic cardiomyopathy 13
p.Tyr5= Single submitter hypertrophic cardiomyopathy 13
p.Ser37= No assertion criteria

Uncertain significance 206

c.202+5G>C Multiple submitters TNNC1-related disorder
c.24+1G>A Multiple submitters hypertrophic cardiomyopathy 13
c.24+2T>G Multiple submitters dilated cardiomyopathy 1Z
c.317+6C>G Multiple submitters dilated cardiomyopathy 1Z
c.454+3A>G Multiple submitters Cardiovascular phenotype
c.454+5G>A Multiple submitters dilated cardiomyopathy 1Z
c.454+6C>G Multiple submitters hypertrophic cardiomyopathy 13
c.55+2T>C Multiple submitters TNNC1-related disorder
c.*75G>A Multiple submitters dilated cardiomyopathy 1Z
p.Ala22Ser Multiple submitters dilated cardiomyopathy 1Z ⚠
p.Ala22Val Multiple submitters Cardiovascular phenotype ⚠
p.Ala31Thr Multiple submitters dilated cardiomyopathy 1Z ⚠
p.Ala7Val Multiple submitters cardiomyopathy
p.Arg102Cys Multiple submitters Cardiovascular phenotype
p.Arg102His Multiple submitters Cardiovascular phenotype ⚠
p.Arg102Leu Multiple submitters dilated cardiomyopathy 1Z ⚠
p.Arg147Cys Multiple submitters cardiomyopathy ⚠
p.Arg147His Multiple submitters dilated cardiomyopathy 1Z ⚠
p.Arg83Gln Multiple submitters dilated cardiomyopathy 1Z ⚠
p.Asn107Lys Multiple submitters Cardiovascular phenotype ⚠
p.Asn144del Multiple submitters dilated cardiomyopathy 1Z
p.Asn18Thr Multiple submitters hypertrophic cardiomyopathy 13 ⚠
p.Asp105His Multiple submitters Cardiovascular phenotype ⚠
p.Asp113Asn Multiple submitters dilated cardiomyopathy 1Z
p.Asp131Glu Multiple submitters Cardiovascular phenotype ⚠
p.Asp132Asn Multiple submitters dilated cardiomyopathy 1Z ⚠
p.Asp145Asn Multiple submitters dilated cardiomyopathy 1Z ⚠
p.Asp145Glu Multiple submitters Cardiovascular phenotype ⚠
p.Asp145His Multiple submitters dilated cardiomyopathy 1Z ⚠
p.Asp25Asn Multiple submitters Cardiovascular phenotype ⚠
p.Asp2Asn Multiple submitters dilated cardiomyopathy 1Z ⚠
p.Asp2Gly Multiple submitters Cardiovascular phenotype ⚠
p.Asp62Asn Multiple submitters Cardiovascular phenotype ⚠
p.Asp75Glu Multiple submitters Cardiovascular phenotype ⚠
p.Glu126Lys Multiple submitters Cardiovascular phenotype ⚠
p.Glu134Asp Multiple submitters Cardiovascular phenotype ⚠
p.Glu135Ala Multiple submitters Cardiovascular phenotype ⚠
p.Glu152Asp Multiple submitters Cardiovascular phenotype ⚠
p.Glu32Lys Multiple submitters Cardiovascular phenotype ⚠
p.Glu59fs Multiple submitters dilated cardiomyopathy 1Z
p.Glu63Asp Multiple submitters Cardiovascular phenotype ⚠
p.Glu94Gln Multiple submitters dilated cardiomyopathy 1Z ⚠
p.Glu95Asp Multiple submitters dilated cardiomyopathy 1Z ⚠
p.Gly140Arg Multiple submitters dilated cardiomyopathy 1Z ⚠
p.Gly140Glu Multiple submitters hypertrophic cardiomyopathy 13 ⚠
p.Gly146Ser Multiple submitters hypertrophic cardiomyopathy 13 ⚠
p.Gly68Ser Multiple submitters hypertrophic cardiomyopathy 13
p.Gly70Ser Multiple submitters dilated cardiomyopathy 1Z ⚠
p.Ile112Val Multiple submitters dilated cardiomyopathy 1Z ⚠
p.Ile119Thr Multiple submitters dilated cardiomyopathy 1Z ⚠
p.Ile148Val Multiple submitters hypertrophic cardiomyopathy 13 ⚠
p.Ile61Met Multiple submitters Cardiovascular phenotype
p.Leu114Arg Multiple submitters Cardiovascular phenotype ⚠
p.Leu29Gln Multiple submitters Cardiovascular phenotype ⚠
p.Lys17Glu Multiple submitters hypertrophic cardiomyopathy 13 ⚠
p.Lys39Arg Multiple submitters hypertrophic cardiomyopathy 13 ⚠
p.Lys6Arg Multiple submitters dilated cardiomyopathy 1Z ⚠
p.Lys92Arg Multiple submitters Cardiovascular phenotype ⚠
p.Lys92Ile Multiple submitters dilated cardiomyopathy 1Z ⚠
p.Met103Leu Multiple submitters Cardiovascular phenotype ⚠
p.Met120Val Multiple submitters Cardiovascular phenotype ⚠
p.Met157Ile Multiple submitters Cardiovascular phenotype ⚠
p.Met47Arg Multiple submitters dilated cardiomyopathy 1Z ⚠
p.Met60Ile Multiple submitters Cardiovascular phenotype ⚠
p.Met81Ile Multiple submitters hypertrophic cardiomyopathy 13 ⚠
p.Met81Leu Multiple submitters hypertrophic cardiomyopathy 13 ⚠
p.Met81Thr Multiple submitters dilated cardiomyopathy 1Z ⚠
p.Phe74Cys Multiple submitters dilated cardiomyopathy 1Z ⚠
p.Phe77fs Multiple submitters Cardiovascular phenotype
p.Thr124Pro Multiple submitters Cardiovascular phenotype ⚠
p.Thr129Arg Multiple submitters Cardiovascular phenotype ⚠
p.Thr129Met Multiple submitters hypertrophic cardiomyopathy 13 ⚠
p.Thr53Ala Multiple submitters hypertrophic cardiomyopathy 13
p.Thr71Met Multiple submitters Cardiovascular phenotype ⚠
p.Val44Met Multiple submitters hypertrophic cardiomyopathy 13 ⚠
p.Val9Gly Multiple submitters dilated cardiomyopathy 1Z
p.Val9Ile Multiple submitters hypertrophic cardiomyopathy 13 ⚠
c.202+2T>C Single submitter dilated cardiomyopathy 1Z
c.202+4A>G Single submitter hypertrophic cardiomyopathy 13
c.202+6C>T Single submitter dilated cardiomyopathy 1Z
c.202+9C>T Single submitter cardiomyopathy
c.24+5G>C Single submitter hypertrophic cardiomyopathy 13
c.317+8C>A Single submitter cardiomyopathy
c.318-26_318-1dup Single submitter dilated cardiomyopathy 1Z
c.318-6C>G Single submitter hypertrophic cardiomyopathy 13
c.454+16G>A Single submitter
c.455-3C>T Single submitter dilated cardiomyopathy 1Z
c.55+5G>A Single submitter hypertrophic cardiomyopathy 13
c.-7C>A Single submitter
c.*8C>T Single submitter
p.Ala108fs Single submitter dilated cardiomyopathy 1Z
p.Ala22Glu Single submitter hypertrophic cardiomyopathy 13 ⚠
p.Ala23Asp Single submitter dilated cardiomyopathy 1Z ⚠
p.Ala23Gly Single submitter dilated cardiomyopathy 1Z ⚠
p.Ala8= Single submitter hypertrophic cardiomyopathy 13
p.Ala8Gly Single submitter hypertrophic cardiomyopathy 13
p.Arg102= Single submitter dilated cardiomyopathy 1Z
p.Arg102Ser Single submitter dilated cardiomyopathy 1Z ⚠
p.Arg147Ser Single submitter hypertrophic cardiomyopathy 13 ⚠
p.Arg46Lys Single submitter dilated cardiomyopathy 1Z ⚠
p.Arg83Gly Single submitter dilated cardiomyopathy 1Z ⚠
p.Arg83Trp Single submitter dilated cardiomyopathy 1Z ⚠
p.Asn143Lys Single submitter hypertrophic cardiomyopathy 13 ⚠
p.Asn144Ser Single submitter ⚠
p.Asn18fs Single submitter hypertrophic cardiomyopathy 13
p.Asn18Ser Single submitter Cardiovascular phenotype ⚠
p.Asn51Lys Single submitter ⚠
p.Asp105Gly Single submitter hypertrophic cardiomyopathy 13 ⚠
p.Asp109Val Single submitter hypertrophic cardiomyopathy 13 ⚠
p.Asp113fs Single submitter dilated cardiomyopathy 1Z
p.Asp113Glu Single submitter dilated cardiomyopathy 1Z ⚠
p.Asp131fs Single submitter hypertrophic cardiomyopathy 13
p.Asp132del Single submitter dilated cardiomyopathy 1Z
p.Asp139Ala Single submitter dilated cardiomyopathy 1Z ⚠
p.Asp139Gly Single submitter Cardiovascular phenotype ⚠
p.Asp145Val Single submitter dilated cardiomyopathy 1Z ⚠
p.Asp149Gly Single submitter ⚠
p.Asp151Tyr Single submitter hypertrophic cardiomyopathy 13 ⚠
p.Asp151Val Single submitter dilated cardiomyopathy 1Z ⚠
p.Asp25_Phe27del Single submitter
p.Asp2Val Single submitter dilated cardiomyopathy 1Z ⚠
p.Asp33Asn Single submitter ⚠
p.Asp3Asn Single submitter dilated cardiomyopathy 1Z ⚠
p.Asp3Gly Single submitter dilated cardiomyopathy 1Z
p.Asp62Glu Single submitter dilated cardiomyopathy 1Z
p.Asp62His Single submitter hypertrophic cardiomyopathy 13 ⚠
p.Asp62Tyr Single submitter dilated cardiomyopathy 1Z ⚠
p.Asp65Glu Single submitter dilated cardiomyopathy 1Z ⚠
p.Asp75Asn Single submitter Cardiovascular phenotype ⚠
p.Asp88Tyr Single submitter ⚠
p.Gln122fs Single submitter hypertrophic cardiomyopathy 13
p.Gln16Arg Single submitter ⚠
p.Gln16Glu Single submitter ⚠
p.Gln50His Single submitter dilated cardiomyopathy 1Z ⚠
p.Glu116Asp Single submitter dilated cardiomyopathy 1Z ⚠
p.Glu135Asp Single submitter TNNC1-related disorder ⚠
p.Glu15Asp Single submitter hypertrophic cardiomyopathy 13 ⚠
p.Glu161Asp Single submitter hypertrophic cardiomyopathy 13 ⚠
p.Glu161fs Single submitter Cardiovascular phenotype
p.Glu19Asp Single submitter Cardiovascular phenotype ⚠
p.Glu55fs Single submitter dilated cardiomyopathy 1Z
p.Glu55Lys Single submitter dilated cardiomyopathy 1Z ⚠
p.Glu59del Single submitter Cardiovascular phenotype
p.Glu59Lys Single submitter hypertrophic cardiomyopathy 13
p.Glu63Ala Single submitter dilated cardiomyopathy 1Z ⚠
p.Glu66Lys Single submitter dilated cardiomyopathy 1Z
p.Glu96del Single submitter
p.Glu96Gly Single submitter ⚠
p.Glu96Met Single submitter dilated cardiomyopathy 1Z
p.Gly110Cys Single submitter hypertrophic cardiomyopathy 13 ⚠
p.Gly146Arg Single submitter hypertrophic cardiomyopathy 13 ⚠
p.Gly146Cys Single submitter hypertrophic cardiomyopathy 13 ⚠
p.Gly159Ser Single submitter ⚠
p.Gly30fs Single submitter dilated cardiomyopathy 1Z
p.Gly42Asp Single submitter dilated cardiomyopathy 1Z ⚠
p.Gly91Arg Single submitter hypertrophic cardiomyopathy 13 ⚠
p.Ile112Met Single submitter dilated cardiomyopathy 1Z ⚠
p.Ile119Val Single submitter hypertrophic cardiomyopathy 13 ⚠
p.Ile128Asn Single submitter dilated cardiomyopathy 1Z ⚠
p.Ile128Thr Single submitter hypertrophic cardiomyopathy 13 ⚠
p.Ile133Met Single submitter hypertrophic cardiomyopathy 13 ⚠
p.Ile133Val Single submitter dilated cardiomyopathy 1Z ⚠
p.Ile4Thr Single submitter ⚠
p.Leu100Phe Single submitter dilated cardiomyopathy 1Z ⚠
p.Leu121_Gln122delinsProTer Single submitter hypertrophic cardiomyopathy 13
p.Leu41Met Single submitter dilated cardiomyopathy 1Z ⚠
p.Leu48= Single submitter
p.Leu97Met Single submitter hypertrophic cardiomyopathy 13
p.Lys118Asn Single submitter dilated cardiomyopathy 1Z ⚠
p.Lys138Glu Single submitter Cardiovascular phenotype ⚠
p.Lys142Asn Single submitter dilated cardiomyopathy 1Z ⚠
p.Lys142fs Single submitter Cardiovascular phenotype
p.Lys158Arg Single submitter dilated cardiomyopathy 1Z ⚠
p.Lys158Thr Single submitter dilated cardiomyopathy 1Z
p.Lys17Thr Single submitter dilated cardiomyopathy 1Z ⚠
p.Lys6Gln Single submitter hypertrophic cardiomyopathy 13 ⚠
p.Lys86Thr Single submitter dilated cardiomyopathy 1Z ⚠
p.Lys90fs Single submitter dilated cardiomyopathy 1Z
p.Met103Ile Single submitter dilated cardiomyopathy 1Z ⚠
p.Met103Val Single submitter dilated cardiomyopathy 1Z ⚠
p.Met120Leu Single submitter dilated cardiomyopathy 1Z
p.Met157Arg Single submitter dilated cardiomyopathy 1Z ⚠
p.Met157Leu Single submitter dilated cardiomyopathy 1Z
p.Met157Val Single submitter dilated cardiomyopathy 1Z ⚠
p.Met45Val Single submitter hypertrophic cardiomyopathy 13 ⚠
p.Met47Val Single submitter hypertrophic cardiomyopathy 13 ⚠
p.Met85Leu Single submitter Cardiovascular phenotype ⚠
p.Phe104Val Single submitter ⚠
p.Pro52Leu Single submitter dilated cardiomyopathy 1Z ⚠
p.Pro52Ser Single submitter Cardiovascular phenotype ⚠
p.Ser37Gly Single submitter ⚠
p.Ser69Arg Single submitter dilated cardiomyopathy 1Z ⚠
p.Ser89Gly Single submitter hypertrophic cardiomyopathy 13 ⚠
p.Ser93Pro Single submitter ⚠
p.Ser98Cys Single submitter Cardiovascular phenotype ⚠
p.Ter162Tyr Single submitter cardiomyopathy
p.Thr127Ala Single submitter Cardiovascular phenotype ⚠
p.Thr53Asn Single submitter Cardiovascular phenotype ⚠
p.Thr53Ile Single submitter dilated cardiomyopathy 1Z ⚠
p.Tyr111Cys Single submitter dilated cardiomyopathy 1Z ⚠
p.Tyr111His Single submitter dilated cardiomyopathy 1Z ⚠
p.Val160Ala Single submitter Cardiovascular phenotype
p.Val28Met Single submitter Cardiovascular phenotype ⚠
p.Val64Ala Single submitter ⚠
p.Val72Ala Single submitter dilated cardiomyopathy 1Z ⚠
p.Val79Leu Single submitter Cardiovascular phenotype