TOMM22 — 8 ClinVar variants
All ClinVar germline TOMM22 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
8 Uncertain significance
Full TOMM22 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TOMM22 p.Ala134Pro Uncertain significance Single submitter
- TOMM22 p.Arg117Trp Uncertain significance Single submitter
- TOMM22 p.Gln107His Uncertain significance Single submitter
- TOMM22 p.Gly133Glu Uncertain significance Single submitter
- TOMM22 p.Leu127Val Uncertain significance Single submitter
- TOMM22 p.Leu135Pro Uncertain significance Single submitter
- TOMM22 p.Pro136Leu Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All TOMM22 variants
Uncertain significance 8
- p.Ala134Pro Single submitter ⚠
- p.Arg117Trp Single submitter ⚠
- p.Gln107His Single submitter ⚠
- p.Gly133Glu Single submitter ⚠
- p.Leu127Val Single submitter ⚠
- p.Leu135Pro Single submitter ⚠
- p.Lys105Glu Single submitter ⚠
- p.Pro136Leu Single submitter ⚠