TOMM34 — 26 ClinVar variants
All ClinVar germline TOMM34 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
1 Likely benign · 25 Uncertain significance
Full TOMM34 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TOMM34 p.Ala273Pro Uncertain significance Single submitter
- TOMM34 p.Ala79Val Uncertain significance Single submitter
- TOMM34 p.Arg267Trp Uncertain significance Single submitter
- TOMM34 p.Arg301Leu Uncertain significance Single submitter
- TOMM34 p.Arg90Gln Uncertain significance Single submitter
- TOMM34 p.Asn208Lys Uncertain significance Single submitter
- TOMM34 p.Asn56Lys Uncertain significance Single submitter
- TOMM34 p.Asp249Gly Uncertain significance Single submitter
- TOMM34 p.Cys222Tyr Uncertain significance Single submitter
- TOMM34 p.Gln289His Uncertain significance Single submitter
- TOMM34 p.Glu214Asp Uncertain significance Single submitter
- TOMM34 p.Lys272Arg Uncertain significance Single submitter
- TOMM34 p.Lys299Arg Uncertain significance Single submitter
- TOMM34 p.Pro102Ser Uncertain significance Single submitter
- TOMM34 p.Pro47Ser Uncertain significance Single submitter
- TOMM34 p.Pro87His Uncertain significance Single submitter
- TOMM34 p.Ser135Leu Uncertain significance Single submitter
- TOMM34 p.Ser172Gly Uncertain significance Single submitter
- TOMM34 p.Thr244Ile Uncertain significance Single submitter
- TOMM34 p.Val122Ala Uncertain significance Single submitter
- TOMM34 p.Val122Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All TOMM34 variants
Likely benign 1
- p.Asn286Ser Single submitter
Uncertain significance 25
- p.Ala273Pro Single submitter ⚠
- p.Ala79Val Single submitter ⚠
- p.Arg141His Single submitter ⚠
- p.Arg157Ser Single submitter
- p.Arg267Trp Single submitter ⚠
- p.Arg301Leu Single submitter ⚠
- p.Arg57Gln Single submitter ⚠
- p.Arg90Gln Single submitter ⚠
- p.Asn208Lys Single submitter ⚠
- p.Asn56Lys Single submitter ⚠
- p.Asp249Gly Single submitter ⚠
- p.Cys222Tyr Single submitter ⚠
- p.Gln289His Single submitter ⚠
- p.Glu214Asp Single submitter ⚠
- p.Glu245Gly Single submitter ⚠
- p.Lys272Arg Single submitter ⚠
- p.Lys299Arg Single submitter ⚠
- p.Pro102Ser Single submitter ⚠
- p.Pro47Ser Single submitter ⚠
- p.Pro87His Single submitter ⚠
- p.Ser135Leu Single submitter ⚠
- p.Ser172Gly Single submitter ⚠
- p.Thr244Ile Single submitter ⚠
- p.Val122Ala Single submitter ⚠
- p.Val122Ile Single submitter ⚠