TP53I3 — 61 ClinVar variants
All ClinVar germline TP53I3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
4 Benign · 16 Likely benign · 41 Uncertain significance
Full TP53I3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TP53I3 p.Arg162Leu Uncertain significance Single submitter
- TP53I3 p.Arg41Pro Uncertain significance Single submitter
- TP53I3 p.Arg47Ile Uncertain significance Single submitter
- TP53I3 p.Asn271Asp Uncertain significance Single submitter
- TP53I3 p.Asp215Gly Uncertain significance Single submitter
- TP53I3 p.Asp43Asn Uncertain significance Single submitter
- TP53I3 p.Asp43Gly Uncertain significance Single submitter
- TP53I3 p.Gln311Glu Uncertain significance Single submitter
- TP53I3 p.Gln77Arg Uncertain significance Single submitter
- TP53I3 p.Glu309Lys Uncertain significance Single submitter
- TP53I3 p.Gly173Ser Uncertain significance Single submitter
- TP53I3 p.Gly92Arg Uncertain significance Single submitter
- TP53I3 p.Gly94Asp Uncertain significance Single submitter
- TP53I3 p.Ile262Thr Uncertain significance Single submitter
- TP53I3 p.Ile323Thr Uncertain significance Single submitter
- TP53I3 p.Met180Lys Uncertain significance Single submitter
- TP53I3 p.Phe6Ser Uncertain significance Single submitter
- TP53I3 p.Pro23Ser Uncertain significance Single submitter
- TP53I3 p.Pro249His Uncertain significance Single submitter
- TP53I3 p.Pro306Ser Uncertain significance Single submitter
- TP53I3 p.Pro74Ser Uncertain significance Single submitter
- TP53I3 p.Ser252Pro Uncertain significance Single submitter
- TP53I3 p.Thr201Met Uncertain significance Single submitter
- TP53I3 p.Thr308Ile Uncertain significance Single submitter
- TP53I3 p.Tyr143His Uncertain significance Single submitter
- TP53I3 p.Val20Met Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- TP53I3 p.Arg162Trp Uncertain significance Single submitter
- TP53I3 p.Arg258Gln Uncertain significance Single submitter
- TP53I3 p.Glu103Lys Uncertain significance Single submitter
- TP53I3 p.Glu19Ala Uncertain significance Single submitter
- TP53I3 p.Leu105Val Uncertain significance Single submitter
- TP53I3 p.Leu63Phe Uncertain significance Single submitter
- TP53I3 p.Met317Thr Uncertain significance Single submitter
- TP53I3 p.Phe204Leu Uncertain significance Single submitter
- TP53I3 p.Pro108Leu Uncertain significance Single submitter
- TP53I3 p.Pro12Leu Uncertain significance Single submitter
-
TP53I3 p.Pro54Ser
Uncertain significance
Single submitter
TP53I3-related disorder
- TP53I3 p.Pro55Leu Uncertain significance Single submitter
- TP53I3 p.Trp222Arg Uncertain significance Single submitter
-
TP53I3 p.Asp84Asn
Likely benign
No assertion criteria
TP53I3-related disorder
All TP53I3 variants
Benign 4
Likely benign 16
- p.Asn271Lys Single submitter
- p.Gly293= Single submitter
- p.Met45Ile Single submitter
- c.138+5C>A No assertion criteria TP53I3-related disorder
- c.817-8T>C No assertion criteria TP53I3-related disorder
- c.*7A>G No assertion criteria TP53I3-related disorder
- c.*8T>G No assertion criteria TP53I3-related disorder
- p.Asp84Asn No assertion criteria TP53I3-related disorder ⚠
- p.Glu195Asp No assertion criteria TP53I3-related disorder
- p.Gly244= No assertion criteria TP53I3-related disorder
- p.His147= No assertion criteria TP53I3-related disorder
- p.Leu113= No assertion criteria TP53I3-related disorder
- p.Pro25= No assertion criteria TP53I3-related disorder
- p.Ser252Ter No assertion criteria TP53I3-related disorder
- p.Ser268= No assertion criteria TP53I3-related disorder
- p.Trp222Ter No assertion criteria TP53I3-related disorder
Uncertain significance 41
- p.Arg162Leu Single submitter ⚠
- p.Arg162Trp Single submitter ⚠
- p.Arg258Gln Single submitter ⚠
- p.Arg41Pro Single submitter ⚠
- p.Arg47Ile Single submitter ⚠
- p.Asn271Asp Single submitter ⚠
- p.Asp215Gly Single submitter ⚠
- p.Asp43Asn Single submitter ⚠
- p.Asp43Gly Single submitter ⚠
- p.Gln311Glu Single submitter ⚠
- p.Gln77Arg Single submitter ⚠
- p.Glu103Lys Single submitter ⚠
- p.Glu19Ala Single submitter ⚠
- p.Glu309Lys Single submitter ⚠
- p.Gly173Ser Single submitter ⚠
- p.Gly209Ala Single submitter
- p.Gly92Arg Single submitter ⚠
- p.Gly94Asp Single submitter ⚠
- p.Ile262Thr Single submitter ⚠
- p.Ile323Thr Single submitter ⚠
- p.Leu105Val Single submitter ⚠
- p.Leu63Phe Single submitter ⚠
- p.Met180Lys Single submitter ⚠
- p.Met317Thr Single submitter ⚠
- p.Phe204Leu Single submitter ⚠
- p.Phe6Ser Single submitter ⚠
- p.Pro108Leu Single submitter ⚠
- p.Pro12Leu Single submitter ⚠
- p.Pro23Ser Single submitter ⚠
- p.Pro249His Single submitter ⚠
- p.Pro306Ser Single submitter ⚠
- p.Pro54Ser Single submitter TP53I3-related disorder ⚠
- p.Pro55Leu Single submitter ⚠
- p.Pro74Ser Single submitter ⚠
- p.Ser252Pro Single submitter ⚠
- p.Thr201Met Single submitter ⚠
- p.Thr308Ile Single submitter ⚠
- p.Trp222Arg Single submitter ⚠
- p.Tyr143His Single submitter ⚠
- p.Val20Met Single submitter ⚠
- p.Arg234Ter No assertion criteria TP53I3-related disorder