TPST2 — 52 ClinVar variants
All ClinVar germline TPST2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 50 flagged for review →
52 Uncertain significance
Full TPST2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 50
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TPST2 p.Ala126Val Uncertain significance Single submitter
- TPST2 p.Ala12Val Uncertain significance Single submitter
- TPST2 p.Ala152Ser Uncertain significance Single submitter
- TPST2 p.Ala263Ser Uncertain significance Single submitter
- TPST2 p.Ala357Asp Uncertain significance Single submitter
- TPST2 p.Ala36Val Uncertain significance Single submitter
- TPST2 p.Ala44Thr Uncertain significance Single submitter
- TPST2 p.Arg101Leu Uncertain significance Single submitter
- TPST2 p.Arg171His Uncertain significance Single submitter
- TPST2 p.Arg195Cys Uncertain significance Single submitter
- TPST2 p.Arg284Gln Uncertain significance Single submitter
- TPST2 p.Arg2His Uncertain significance Single submitter
- TPST2 p.Arg32Gln Uncertain significance Single submitter
- TPST2 p.Arg347Gln Uncertain significance Single submitter
- TPST2 p.Arg39Gln Uncertain significance Single submitter
- TPST2 p.Arg42Gln Uncertain significance Single submitter
- TPST2 p.Arg42Trp Uncertain significance Single submitter
- TPST2 p.Arg46Gln Uncertain significance Single submitter
- TPST2 p.Arg63His Uncertain significance Single submitter
- TPST2 p.Arg6Gln Uncertain significance Single submitter
- TPST2 p.Arg6Trp Uncertain significance Single submitter
- TPST2 p.Arg7Ser Uncertain significance Single submitter
- TPST2 p.Arg85His Uncertain significance Single submitter
- TPST2 p.Asn157Asp Uncertain significance Single submitter
- TPST2 p.Asn330Ile Uncertain significance Single submitter
- TPST2 p.Asp254Asn Uncertain significance Single submitter
- TPST2 p.Asp308Glu Uncertain significance Single submitter
- TPST2 p.Glu131Lys Uncertain significance Single submitter
- TPST2 p.Glu283Lys Uncertain significance Single submitter
- TPST2 p.Glu30Gln Uncertain significance Single submitter
- TPST2 p.Glu93Gln Uncertain significance Single submitter
- TPST2 p.Ile290Val Uncertain significance Single submitter
- TPST2 p.Leu16Val Uncertain significance Single submitter
- TPST2 p.Leu265Arg Uncertain significance Single submitter
- TPST2 p.Lys216Glu Uncertain significance Single submitter
- TPST2 p.Lys250Arg Uncertain significance Single submitter
- TPST2 p.Ser261Asn Uncertain significance Single submitter
- TPST2 p.Ser285Phe Uncertain significance Single submitter
- TPST2 p.Thr162Met Uncertain significance Single submitter
- TPST2 p.Thr198Ile Uncertain significance Single submitter
- TPST2 p.Val106Leu Uncertain significance Single submitter
- TPST2 p.Val189Met Uncertain significance Single submitter
- TPST2 p.Val53Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- TPST2 p.Ala297Val Uncertain significance Single submitter
- TPST2 p.Arg247Cys Uncertain significance Single submitter
- TPST2 p.Arg347Trp Uncertain significance Single submitter
- TPST2 p.Arg63Cys Uncertain significance Single submitter
- TPST2 p.Gly257Ser Uncertain significance Single submitter
- TPST2 p.Lys300Gln Uncertain significance Single submitter
- TPST2 p.Val128Leu Uncertain significance Single submitter
All TPST2 variants
Uncertain significance 52
- p.Ala126Val Single submitter ⚠
- p.Ala12Val Single submitter ⚠
- p.Ala152Ser Single submitter ⚠
- p.Ala263Ser Single submitter ⚠
- p.Ala297Val Single submitter ⚠
- p.Ala357Asp Single submitter ⚠
- p.Ala36Val Single submitter ⚠
- p.Ala44Thr Single submitter ⚠
- p.Arg101Leu Single submitter ⚠
- p.Arg171His Single submitter ⚠
- p.Arg195Cys Single submitter ⚠
- p.Arg247Cys Single submitter ⚠
- p.Arg284Gln Single submitter ⚠
- p.Arg2His Single submitter ⚠
- p.Arg32Gln Single submitter ⚠
- p.Arg347Gln Single submitter ⚠
- p.Arg347Trp Single submitter ⚠
- p.Arg39Gln Single submitter ⚠
- p.Arg42Gln Single submitter ⚠
- p.Arg42Trp Single submitter ⚠
- p.Arg46Gln Single submitter ⚠
- p.Arg63Cys Single submitter ⚠
- p.Arg63His Single submitter ⚠
- p.Arg6Gln Single submitter ⚠
- p.Arg6Trp Single submitter ⚠
- p.Arg7Ser Single submitter ⚠
- p.Arg85His Single submitter ⚠
- p.Asn157Asp Single submitter ⚠
- p.Asn330Ile Single submitter ⚠
- p.Asp254Asn Single submitter ⚠
- p.Asp308Glu Single submitter ⚠
- p.Glu131Lys Single submitter ⚠
- p.Glu283Lys Single submitter ⚠
- p.Glu30Gln Single submitter ⚠
- p.Glu93Gln Single submitter ⚠
- p.Gly257Ser Single submitter ⚠
- p.Gly25Arg Single submitter
- p.Ile290Val Single submitter ⚠
- p.Leu16Val Single submitter ⚠
- p.Leu241Val Single submitter
- p.Leu265Arg Single submitter ⚠
- p.Lys216Glu Single submitter ⚠
- p.Lys250Arg Single submitter ⚠
- p.Lys300Gln Single submitter ⚠
- p.Ser261Asn Single submitter ⚠
- p.Ser285Phe Single submitter ⚠
- p.Thr162Met Single submitter ⚠
- p.Thr198Ile Single submitter ⚠
- p.Val106Leu Single submitter ⚠
- p.Val128Leu Single submitter ⚠
- p.Val189Met Single submitter ⚠
- p.Val53Leu Single submitter ⚠