TRAM1 — 33 ClinVar variants
All ClinVar germline TRAM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
1 Benign · 4 Likely benign · 28 Uncertain significance
Full TRAM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TRAM1 p.Ala127Thr Uncertain significance Single submitter
- TRAM1 p.Ala208Thr Uncertain significance Single submitter
- TRAM1 p.Ala277Ser Uncertain significance Single submitter
- TRAM1 p.Ala46Ser Uncertain significance Single submitter
- TRAM1 p.Ala46Val Uncertain significance Single submitter
- TRAM1 p.Asn361Ser Uncertain significance Single submitter
- TRAM1 p.Ile170Val Uncertain significance Single submitter
- TRAM1 p.Ile26Val Uncertain significance Single submitter
- TRAM1 p.Ile48Val Uncertain significance Single submitter
- TRAM1 p.Leu232Ile Uncertain significance Single submitter
- TRAM1 p.Lys335Arg Uncertain significance Single submitter
- TRAM1 p.Phe239Ile Uncertain significance Single submitter
- TRAM1 p.Phe85Cys Uncertain significance Single submitter
- TRAM1 p.Ser327Phe Uncertain significance Single submitter
- TRAM1 p.Thr137Ile Uncertain significance Single submitter
- TRAM1 p.Thr82Ala Uncertain significance Single submitter
- TRAM1 p.Tyr184Cys Uncertain significance Single submitter
- TRAM1 p.Tyr246His Uncertain significance Single submitter
- TRAM1 p.Tyr75His Uncertain significance Single submitter
- TRAM1 p.Val134Ala Uncertain significance Single submitter
- TRAM1 p.Val293Ala Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All TRAM1 variants
Benign 1
- p.Asn144Asp Multiple submitters
Likely benign 4
- p.Gly249= Single submitter
- p.Val134Ile Single submitter
- p.Val306Ile Single submitter
- p.Val96Ile Single submitter
Uncertain significance 28
- p.Ala127Thr Single submitter ⚠
- p.Ala208Thr Single submitter ⚠
- p.Ala277Ser Single submitter ⚠
- p.Ala46Ser Single submitter ⚠
- p.Ala46Val Single submitter ⚠
- p.Arg195His Single submitter ⚠
- p.Arg278Ile Single submitter
- p.Asn361Ser Single submitter ⚠
- p.Ile170Val Single submitter ⚠
- p.Ile26Val Single submitter ⚠
- p.Ile48Val Single submitter ⚠
- p.Leu232Ile Single submitter ⚠
- p.Lys245Met Single submitter ⚠
- p.Lys335Arg Single submitter ⚠
- p.Phe239Ile Single submitter ⚠
- p.Phe239Leu Single submitter
- p.Phe85Cys Single submitter ⚠
- p.Ser327Phe Single submitter ⚠
- p.Ser346Tyr Single submitter ⚠
- p.Thr137Ile Single submitter ⚠
- p.Thr43Met Single submitter ⚠
- p.Thr82Ala Single submitter ⚠
- p.Tyr184Cys Single submitter ⚠
- p.Tyr246His Single submitter ⚠
- p.Tyr75His Single submitter ⚠
- p.Val134Ala Single submitter ⚠
- p.Val293Ala Single submitter ⚠
- p.Val300Ala Single submitter