TRHDE — 105 ClinVar variants
All ClinVar germline TRHDE variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 76 flagged for review →
3 Benign · 2 Likely benign · 100 Uncertain significance
Full TRHDE gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 76
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 74
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TRHDE p.Ala1047Val Uncertain significance Single submitter
- TRHDE p.Ala117Ser Uncertain significance Single submitter
- TRHDE p.Ala121Gly Uncertain significance Single submitter
- TRHDE p.Ala147Ser Uncertain significance Single submitter
- TRHDE p.Ala221Thr Uncertain significance Single submitter
- TRHDE p.Ala229Thr Uncertain significance Single submitter
- TRHDE p.Ala442Pro Uncertain significance Single submitter
- TRHDE p.Ala548Thr Uncertain significance Single submitter
- TRHDE p.Ala619Val Uncertain significance Single submitter
- TRHDE p.Ala65Val Uncertain significance Single submitter
- TRHDE p.Ala831Val Uncertain significance Single submitter
- TRHDE p.Arg1050Ser Uncertain significance Single submitter
- TRHDE p.Arg1068Ser Uncertain significance Single submitter
- TRHDE p.Arg109Leu Uncertain significance Single submitter
- TRHDE p.Arg131His Uncertain significance Single submitter
- TRHDE p.Arg143Leu Uncertain significance Single submitter
- TRHDE p.Arg54Pro Uncertain significance Single submitter
- TRHDE p.Arg752Gln Uncertain significance Single submitter
- TRHDE p.Arg752Trp Uncertain significance Single submitter
- TRHDE p.Arg815His Uncertain significance Single submitter
- TRHDE p.Arg859Cys Uncertain significance Single submitter
- TRHDE p.Arg890Ser Uncertain significance Single submitter
- TRHDE p.Asn288Thr Uncertain significance Single submitter
- TRHDE p.Asn823Asp Uncertain significance Single submitter
- TRHDE p.Asn955Ser Uncertain significance Single submitter
- TRHDE p.Asn993Ser Uncertain significance Single submitter
- TRHDE p.Asp62Gly Uncertain significance Single submitter
- TRHDE p.Gln1056Glu Uncertain significance Single submitter
- TRHDE p.Gln153Lys Uncertain significance Single submitter
- TRHDE p.Gln273Arg Uncertain significance Single submitter
- TRHDE p.Glu1058Asp Uncertain significance Single submitter
- TRHDE p.Glu174Lys Uncertain significance Single submitter
- TRHDE p.Glu388Asp Uncertain significance Single submitter
- TRHDE p.Glu755Lys Uncertain significance Single submitter
- TRHDE p.Gly1018Asp Uncertain significance Single submitter
- TRHDE p.Gly114Glu Uncertain significance Single submitter
- TRHDE p.Gly158Glu Uncertain significance Single submitter
- TRHDE p.Gly163Glu Uncertain significance Single submitter
- TRHDE p.Gly188Arg Uncertain significance Single submitter
- TRHDE p.Gly302Trp Uncertain significance Single submitter
- TRHDE p.His146Asn Uncertain significance Single submitter
- TRHDE p.His301Gln Uncertain significance Single submitter
- TRHDE p.Ile715Val Uncertain significance Single submitter
- TRHDE p.Ile863Leu Uncertain significance Single submitter
- TRHDE p.Leu1059Phe Uncertain significance Single submitter
- TRHDE p.Leu105Met Uncertain significance Single submitter
- TRHDE p.Leu307Val Uncertain significance Single submitter
- TRHDE p.Lys430Glu Uncertain significance Single submitter
- TRHDE p.Lys437Ile Uncertain significance Single submitter
- TRHDE p.Lys673Glu Uncertain significance Single submitter
- TRHDE p.Lys676Arg Uncertain significance Single submitter
- TRHDE p.Met1027Leu Uncertain significance Single submitter
- TRHDE p.Met481Val Uncertain significance Single submitter
- TRHDE p.Met816Thr Uncertain significance Single submitter
- TRHDE p.Pro129Leu Uncertain significance Single submitter
- TRHDE p.Pro170Ser Uncertain significance Single submitter
- TRHDE p.Pro432Leu Uncertain significance Single submitter
- TRHDE p.Pro63Leu Uncertain significance Single submitter
- TRHDE p.Ser116Ile Uncertain significance Single submitter
- TRHDE p.Ser140Leu Uncertain significance Single submitter
- TRHDE p.Thr165Lys Uncertain significance Single submitter
- TRHDE p.Thr165Met Uncertain significance Single submitter
- TRHDE p.Thr716Ala Uncertain significance Single submitter
- TRHDE p.Thr994Ile Uncertain significance Single submitter
- TRHDE p.Trp178Leu Uncertain significance Single submitter
- TRHDE p.Tyr521Cys Uncertain significance Single submitter
- TRHDE p.Tyr523Cys Uncertain significance Single submitter
- TRHDE p.Val1033Ile Uncertain significance Single submitter
- TRHDE p.Val159Met Uncertain significance Single submitter
- TRHDE p.Val299Ala Uncertain significance Single submitter
- TRHDE p.Val499Met Uncertain significance Single submitter
- TRHDE p.Val590Leu Uncertain significance Single submitter
- TRHDE p.Val849Leu Uncertain significance Single submitter
- TRHDE p.Val901Ile Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All TRHDE variants
Benign 3
- c.2470-4T>C Multiple submitters
- p.Glu211= Multiple submitters
- p.Val901= Single submitter
Likely benign 2
- p.Val395= Multiple submitters
- p.Ile728Phe No assertion criteria long QT syndrome
Uncertain significance 100
- p.Ala1047Pro Single submitter
- p.Ala1047Val Single submitter ⚠
- p.Ala117Ser Single submitter ⚠
- p.Ala121Gly Single submitter ⚠
- p.Ala147Ser Single submitter ⚠
- p.Ala221Thr Single submitter ⚠
- p.Ala229Thr Single submitter ⚠
- p.Ala442Pro Single submitter ⚠
- p.Ala511Ser Single submitter
- p.Ala548Thr Single submitter ⚠
- p.Ala607Gly Single submitter
- p.Ala619Val Single submitter ⚠
- p.Ala65Val Single submitter ⚠
- p.Ala831Val Single submitter ⚠
- p.Arg1050Ser Single submitter ⚠
- p.Arg1068Ser Single submitter ⚠
- p.Arg109Leu Single submitter ⚠
- p.Arg131His Single submitter ⚠
- p.Arg143Leu Single submitter ⚠
- p.Arg231Leu Single submitter
- p.Arg54Pro Single submitter ⚠
- p.Arg752Gln Single submitter ⚠
- p.Arg752Trp Single submitter ⚠
- p.Arg815Cys Single submitter
- p.Arg815His Single submitter ⚠
- p.Arg815Leu Single submitter
- p.Arg859Cys Single submitter ⚠
- p.Arg859His Single submitter
- p.Arg890Ser Single submitter ⚠
- p.Asn288Thr Single submitter ⚠
- p.Asn823Asp Single submitter ⚠
- p.Asn955Ser Single submitter ⚠
- p.Asn993Ser Single submitter ⚠
- p.Asp536Asn Single submitter
- p.Asp62Gly Single submitter ⚠
- p.Asp884Tyr Single submitter
- p.Gln1056Glu Single submitter ⚠
- p.Gln153Lys Single submitter ⚠
- p.Gln273Arg Single submitter ⚠
- p.Gln639Lys Single submitter
- p.Glu1012Asp Single submitter ⚠
- p.Glu1058Asp Single submitter ⚠
- p.Glu174Lys Single submitter ⚠
- p.Glu204Lys Single submitter
- p.Glu388Asp Single submitter ⚠
- p.Glu755Lys Single submitter ⚠
- p.Gly1018Asp Single submitter ⚠
- p.Gly114Glu Single submitter ⚠
- p.Gly158Glu Single submitter ⚠
- p.Gly163Glu Single submitter ⚠
- p.Gly188Arg Single submitter ⚠
- p.Gly302Arg Single submitter
- p.Gly302Trp Single submitter ⚠
- p.His146Asn Single submitter ⚠
- p.His301Gln Single submitter ⚠
- p.Ile715Val Single submitter ⚠
- p.Ile786Thr Single submitter
- p.Ile79Ser Single submitter
- p.Ile863Leu Single submitter ⚠
- p.Ile863Thr Single submitter
- p.Leu1059Phe Single submitter ⚠
- p.Leu105Met Single submitter ⚠
- p.Leu307Val Single submitter ⚠
- p.Lys430Glu Single submitter ⚠
- p.Lys437Ile Single submitter ⚠
- p.Lys673Glu Single submitter ⚠
- p.Lys676Arg Single submitter ⚠
- p.Met1027Leu Single submitter ⚠
- p.Met203Thr Single submitter
- p.Met372Leu Single submitter
- p.Met481Val Single submitter ⚠
- p.Met528Thr Single submitter
- p.Met586Ile Single submitter ⚠
- p.Met816Thr Single submitter ⚠
- p.Phe424Leu Single submitter
- p.Pro129Leu Single submitter ⚠
- p.Pro170Ser Single submitter ⚠
- p.Pro370Ala Single submitter
- p.Pro432Leu Single submitter ⚠
- p.Pro447Leu Single submitter
- p.Pro63Leu Single submitter ⚠
- p.Ser116Ile Single submitter ⚠
- p.Ser140Leu Single submitter ⚠
- p.Thr165Lys Single submitter ⚠
- p.Thr165Met Single submitter ⚠
- p.Thr689Ile Single submitter
- p.Thr716Ala Single submitter ⚠
- p.Thr994Ile Single submitter ⚠
- p.Trp178Leu Single submitter ⚠
- p.Tyr521Cys Single submitter ⚠
- p.Tyr523Cys Single submitter ⚠
- p.Val1033Ile Single submitter ⚠
- p.Val159Met Single submitter ⚠
- p.Val299Ala Single submitter ⚠
- p.Val499Met Single submitter ⚠
- p.Val590Leu Single submitter ⚠
- p.Val632Gly Single submitter
- p.Val644Ala Single submitter
- p.Val849Leu Single submitter ⚠
- p.Val901Ile Single submitter ⚠