TRIM33 — 61 ClinVar variants
All ClinVar germline TRIM33 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
1 Pathogenic · 1 Likely pathogenic · 8 Benign · 1 Likely benign · 50 Uncertain significance
Full TRIM33 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TRIM33 p.Ala226Val Uncertain significance Single submitter
- TRIM33 p.Ala761Thr Uncertain significance Single submitter
- TRIM33 p.Ala832Val Uncertain significance Single submitter
- TRIM33 p.Arg1116His Uncertain significance Single submitter
- TRIM33 p.Asn386His Uncertain significance Single submitter
- TRIM33 p.Asn637Thr Uncertain significance Single submitter
- TRIM33 p.Asn879Thr Uncertain significance Single submitter
- TRIM33 p.Asp1120Asn Uncertain significance Single submitter
- TRIM33 p.Asp261Gly Uncertain significance Single submitter
- TRIM33 p.Asp697Tyr Uncertain significance Single submitter
- TRIM33 p.Gln160Arg Uncertain significance Single submitter
- TRIM33 p.Gln794Glu Uncertain significance Single submitter
- TRIM33 p.Gln956His Uncertain significance Single submitter
- TRIM33 p.Gly116Val Uncertain significance Single submitter
- TRIM33 p.Gly168Val Uncertain significance Single submitter
- TRIM33 p.Gly607Ser Uncertain significance Single submitter
- TRIM33 p.Gly7Asp Uncertain significance Single submitter
- TRIM33 p.His528Gln Uncertain significance Single submitter
- TRIM33 p.Ile990Val Uncertain significance Single submitter
- TRIM33 p.Leu1117Val Uncertain significance Single submitter
- TRIM33 p.Leu867Phe Uncertain significance Single submitter
- TRIM33 p.Lys212Thr Uncertain significance Single submitter
- TRIM33 p.Met575Ile Uncertain significance Single submitter
- TRIM33 p.Phe1092Tyr Uncertain significance Single submitter
- TRIM33 p.Pro1090Thr Uncertain significance Single submitter
- TRIM33 p.Pro113Arg Uncertain significance Single submitter
- TRIM33 p.Pro711Ala Uncertain significance Single submitter
- TRIM33 p.Ser208Ile Uncertain significance Single submitter
- TRIM33 p.Ser871Leu Uncertain significance Single submitter
- TRIM33 p.Thr781Ser Uncertain significance Single submitter
- TRIM33 p.Thr917Ile Uncertain significance Single submitter
- TRIM33 p.Trp466Cys Uncertain significance Single submitter
- TRIM33 p.Val632Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- TRIM33 p.Ala651Glu Uncertain significance Single submitter
- TRIM33 p.Asn641Asp Uncertain significance Single submitter
- TRIM33 p.Asp1022Gly Uncertain significance Single submitter
- TRIM33 p.Asp783His Uncertain significance Single submitter
- TRIM33 p.Cys943Tyr Uncertain significance Single submitter
-
TRIM33 p.Gly404Ser
Benign
Single submitter
ovarian cancer
- TRIM33 p.Ile373Leu Uncertain significance Single submitter
- TRIM33 p.Ile934Thr Uncertain significance Single submitter
- TRIM33 p.Met519Val Uncertain significance Single submitter
- TRIM33 p.Pro629Thr Uncertain significance Single submitter
- TRIM33 p.Ser71Phe Uncertain significance Single submitter
All TRIM33 variants
Pathogenic 1
- p.Thr550_Gln551insThr No assertion criteria developmental dysplasia of the hip 4
Likely pathogenic 1
- p.Thr550_Gln551insCys Single submitter developmental dysplasia of the hip
Benign 8
- p.Gln382= Multiple submitters
- p.Leu831= Multiple submitters
- p.Pro629= Multiple submitters
- p.Pro960= Multiple submitters
- p.Ala138Thr Single submitter ovarian cancer
- p.Gly404Ser Single submitter ovarian cancer ⚠
- p.Ser826Thr Single submitter ovarian cancer
- p.Thr638= Single submitter
Likely benign 1
- p.Ser606= Single submitter
Uncertain significance 50
- p.Ala226Val Single submitter ⚠
- p.Ala651Glu Single submitter ⚠
- p.Ala761Thr Single submitter ⚠
- p.Ala832Val Single submitter ⚠
- p.Arg1116His Single submitter ⚠
- p.Arg440His Single submitter
- p.Asn386His Single submitter ⚠
- p.Asn637Thr Single submitter ⚠
- p.Asn641Asp Single submitter ⚠
- p.Asn879Thr Single submitter ⚠
- p.Asp1022Gly Single submitter ⚠
- p.Asp1120Asn Single submitter ⚠
- p.Asp210His Single submitter
- p.Asp261Gly Single submitter ⚠
- p.Asp697Tyr Single submitter ⚠
- p.Asp783His Single submitter ⚠
- p.Cys943Tyr Single submitter ⚠
- p.Gln160Arg Single submitter ⚠
- p.Gln794Glu Single submitter ⚠
- p.Gln956His Single submitter ⚠
- p.Gly116Val Single submitter ⚠
- p.Gly168Val Single submitter ⚠
- p.Gly607Ser Single submitter ⚠
- p.Gly7Asp Single submitter ⚠
- p.His528Gln Single submitter ⚠
- p.His636Arg Single submitter
- p.Ile373Leu Single submitter ⚠
- p.Ile934Thr Single submitter ⚠
- p.Ile990Val Single submitter ⚠
- p.Leu1117Val Single submitter ⚠
- p.Leu867Phe Single submitter ⚠
- p.Lys212Thr Single submitter ⚠
- p.Met519Val Single submitter ⚠
- p.Met575Ile Single submitter ⚠
- p.Phe1092Tyr Single submitter ⚠
- p.Pro1090Thr Single submitter ⚠
- p.Pro113Arg Single submitter ⚠
- p.Pro629Thr Single submitter ⚠
- p.Pro711Ala Single submitter ⚠
- p.Pro728Leu Single submitter
- p.Ser208Ile Single submitter ⚠
- p.Ser71Phe Single submitter ⚠
- p.Ser871Leu Single submitter ⚠
- p.Ser989Leu Single submitter
- p.Thr781Ser Single submitter ⚠
- p.Thr917Ile Single submitter ⚠
- p.Trp466Cys Single submitter ⚠
- p.Tyr1072His Single submitter
- p.Val632Ile Single submitter ⚠
- p.Val632Leu Single submitter