TRIM4 — 74 ClinVar variants
All ClinVar germline TRIM4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 71 flagged for review →
3 Likely benign · 71 Uncertain significance
Full TRIM4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 71
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 56
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TRIM4 p.Ala119Thr Uncertain significance Single submitter
- TRIM4 p.Ala121Thr Uncertain significance Single submitter
- TRIM4 p.Ala159Thr Uncertain significance Single submitter
- TRIM4 p.Arg103Gln Uncertain significance Single submitter
- TRIM4 p.Arg139Gly Uncertain significance Single submitter
- TRIM4 p.Arg139His Uncertain significance Single submitter
- TRIM4 p.Arg139Leu Uncertain significance Single submitter
- TRIM4 p.Arg170Gln Uncertain significance Single submitter
- TRIM4 p.Arg172Gly Uncertain significance Single submitter
- TRIM4 p.Arg381Cys Uncertain significance Single submitter
- TRIM4 p.Arg381His Uncertain significance Single submitter
- TRIM4 p.Arg419Gln Uncertain significance Single submitter
- TRIM4 p.Arg426Gly Uncertain significance Single submitter
- TRIM4 p.Asn196Lys Uncertain significance Single submitter
- TRIM4 p.Asn214Ser Uncertain significance Single submitter
- TRIM4 p.Asn39Lys Uncertain significance Single submitter
- TRIM4 p.Asn430His Uncertain significance Single submitter
- TRIM4 p.Asn430Thr Uncertain significance Single submitter
- TRIM4 p.Asp153Glu Uncertain significance Single submitter
- TRIM4 p.Asp21His Uncertain significance Single submitter
- TRIM4 p.Cys109Phe Uncertain significance Single submitter
- TRIM4 p.Gln20His Uncertain significance Single submitter
- TRIM4 p.Gln215His Uncertain significance Single submitter
- TRIM4 p.Gln268His Uncertain significance Single submitter
- TRIM4 p.Glu128Gln Uncertain significance Single submitter
- TRIM4 p.Glu250Lys Uncertain significance Single submitter
- TRIM4 p.Gly43Asp Uncertain significance Single submitter
- TRIM4 p.His29Asp Uncertain significance Single submitter
- TRIM4 p.Ile166Thr Uncertain significance Single submitter
- TRIM4 p.Ile25Leu Uncertain significance Single submitter
- TRIM4 p.Ile393Val Uncertain significance Single submitter
- TRIM4 p.Leu10Val Uncertain significance Single submitter
- TRIM4 p.Leu134Ile Uncertain significance Single submitter
- TRIM4 p.Leu258Phe Uncertain significance Single submitter
- TRIM4 p.Leu403Phe Uncertain significance Single submitter
- TRIM4 p.Pro234Ala Uncertain significance Single submitter
- TRIM4 p.Pro270Ser Uncertain significance Single submitter
- TRIM4 p.Pro292Ala Uncertain significance Single submitter
- TRIM4 p.Pro292Ser Uncertain significance Single submitter
- TRIM4 p.Pro46Gln Uncertain significance Single submitter
- TRIM4 p.Ser174Ile Uncertain significance Single submitter
- TRIM4 p.Ser310Cys Uncertain significance Single submitter
- TRIM4 p.Ser317Leu Uncertain significance Single submitter
- TRIM4 p.Ser446Pro Uncertain significance Single submitter
- TRIM4 p.Thr175Met Uncertain significance Single submitter
- TRIM4 p.Thr210Met Uncertain significance Single submitter
- TRIM4 p.Thr247Asn Uncertain significance Single submitter
- TRIM4 p.Thr289Arg Uncertain significance Single submitter
- TRIM4 p.Trp325Arg Uncertain significance Single submitter
- TRIM4 p.Val142Met Uncertain significance Single submitter
- TRIM4 p.Val295Ile Uncertain significance Single submitter
- TRIM4 p.Val334Ile Uncertain significance Single submitter
- TRIM4 p.Val348Ile Uncertain significance Single submitter
- TRIM4 p.Val358Leu Uncertain significance Single submitter
- TRIM4 p.Val375Ile Uncertain significance Single submitter
- TRIM4 p.Val437Met Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- TRIM4 p.Arg336Gly Uncertain significance Single submitter
- TRIM4 p.Asn305Asp Uncertain significance Single submitter
- TRIM4 p.Cys106Tyr Uncertain significance Single submitter
- TRIM4 p.Glu176Ala Uncertain significance Single submitter
- TRIM4 p.Glu199Lys Uncertain significance Single submitter
- TRIM4 p.Gly28Ser Uncertain significance Single submitter
- TRIM4 p.Gly399Val Uncertain significance Single submitter
- TRIM4 p.Gly439Arg Uncertain significance Single submitter
- TRIM4 p.His181Pro Uncertain significance Single submitter
- TRIM4 p.Leu223Arg Uncertain significance Single submitter
- TRIM4 p.Lys230Glu Uncertain significance Single submitter
- TRIM4 p.Ser351Leu Uncertain significance Single submitter
- TRIM4 p.Ser460Arg Uncertain significance Single submitter
- TRIM4 p.Thr265Ile Uncertain significance Single submitter
- TRIM4 p.Val245Glu Uncertain significance Single submitter
All TRIM4 variants
Likely benign 3
- p.Arg278Gln Single submitter
- p.Arg473Gly Single submitter
- p.Thr117Ala Single submitter
Uncertain significance 71
- p.Ala119Thr Single submitter ⚠
- p.Ala121Thr Single submitter ⚠
- p.Ala159Thr Single submitter ⚠
- p.Arg103Gln Single submitter ⚠
- p.Arg139Gly Single submitter ⚠
- p.Arg139His Single submitter ⚠
- p.Arg139Leu Single submitter ⚠
- p.Arg170Gln Single submitter ⚠
- p.Arg172Gly Single submitter ⚠
- p.Arg336Gly Single submitter ⚠
- p.Arg381Cys Single submitter ⚠
- p.Arg381His Single submitter ⚠
- p.Arg419Gln Single submitter ⚠
- p.Arg426Gly Single submitter ⚠
- p.Asn196Lys Single submitter ⚠
- p.Asn214Ser Single submitter ⚠
- p.Asn305Asp Single submitter ⚠
- p.Asn39Lys Single submitter ⚠
- p.Asn430His Single submitter ⚠
- p.Asn430Thr Single submitter ⚠
- p.Asp153Glu Single submitter ⚠
- p.Asp21His Single submitter ⚠
- p.Cys106Tyr Single submitter ⚠
- p.Cys109Phe Single submitter ⚠
- p.Gln20His Single submitter ⚠
- p.Gln215His Single submitter ⚠
- p.Gln268His Single submitter ⚠
- p.Glu128Gln Single submitter ⚠
- p.Glu176Ala Single submitter ⚠
- p.Glu199Lys Single submitter ⚠
- p.Glu250Lys Single submitter ⚠
- p.Gly28Ser Single submitter ⚠
- p.Gly399Val Single submitter ⚠
- p.Gly439Arg Single submitter ⚠
- p.Gly43Asp Single submitter ⚠
- p.His181Pro Single submitter ⚠
- p.His29Asp Single submitter ⚠
- p.Ile166Thr Single submitter ⚠
- p.Ile25Leu Single submitter ⚠
- p.Ile393Val Single submitter ⚠
- p.Leu10Val Single submitter ⚠
- p.Leu134Ile Single submitter ⚠
- p.Leu223Arg Single submitter ⚠
- p.Leu258Phe Single submitter ⚠
- p.Leu403Phe Single submitter ⚠
- p.Lys230Glu Single submitter ⚠
- p.Pro234Ala Single submitter ⚠
- p.Pro270Ser Single submitter ⚠
- p.Pro292Ala Single submitter ⚠
- p.Pro292Ser Single submitter ⚠
- p.Pro46Gln Single submitter ⚠
- p.Ser174Ile Single submitter ⚠
- p.Ser310Cys Single submitter ⚠
- p.Ser317Leu Single submitter ⚠
- p.Ser351Leu Single submitter ⚠
- p.Ser446Pro Single submitter ⚠
- p.Ser460Arg Single submitter ⚠
- p.Thr175Met Single submitter ⚠
- p.Thr210Met Single submitter ⚠
- p.Thr247Asn Single submitter ⚠
- p.Thr265Ile Single submitter ⚠
- p.Thr289Arg Single submitter ⚠
- p.Trp325Arg Single submitter ⚠
- p.Val142Met Single submitter ⚠
- p.Val245Glu Single submitter ⚠
- p.Val295Ile Single submitter ⚠
- p.Val334Ile Single submitter ⚠
- p.Val348Ile Single submitter ⚠
- p.Val358Leu Single submitter ⚠
- p.Val375Ile Single submitter ⚠
- p.Val437Met Single submitter ⚠