TRMT1L — 79 ClinVar variants
All ClinVar germline TRMT1L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 76 flagged for review →
3 Likely benign · 76 Uncertain significance
Full TRMT1L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 76
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TRMT1L p.Ala105Val Uncertain significance Single submitter
- TRMT1L p.Ala120Pro Uncertain significance Single submitter
- TRMT1L p.Ala120Thr Uncertain significance Single submitter
- TRMT1L p.Ala271Ser Uncertain significance Single submitter
- TRMT1L p.Ala385Ser Uncertain significance Single submitter
- TRMT1L p.Ala479Thr Uncertain significance Single submitter
- TRMT1L p.Ala5Val Uncertain significance Single submitter
- TRMT1L p.Ala679Pro Uncertain significance Single submitter
- TRMT1L p.Ala76Ser Uncertain significance Single submitter
- TRMT1L p.Arg165Gln Uncertain significance Single submitter
- TRMT1L p.Arg260Trp Uncertain significance Single submitter
- TRMT1L p.Arg509Gly Uncertain significance Single submitter
- TRMT1L p.Asn350Ser Uncertain significance Single submitter
- TRMT1L p.Asn350Thr Uncertain significance Single submitter
- TRMT1L p.Asn3Lys Uncertain significance Single submitter
- TRMT1L p.Asn584Ser Uncertain significance Single submitter
- TRMT1L p.Asp499Glu Uncertain significance Single submitter
- TRMT1L p.Asp723Asn Uncertain significance Single submitter
- TRMT1L p.Gln237Glu Uncertain significance Single submitter
- TRMT1L p.Glu16Val Uncertain significance Single submitter
- TRMT1L p.Gly620Ser Uncertain significance Single submitter
- TRMT1L p.His202Tyr Uncertain significance Single submitter
- TRMT1L p.His296Leu Uncertain significance Single submitter
- TRMT1L p.Ile288Val Uncertain significance Single submitter
- TRMT1L p.Ile305Val Uncertain significance Single submitter
- TRMT1L p.Ile340Thr Uncertain significance Single submitter
- TRMT1L p.Ile389Val Uncertain significance Single submitter
- TRMT1L p.Ile577Thr Uncertain significance Single submitter
- TRMT1L p.Ile593Asn Uncertain significance Single submitter
- TRMT1L p.Ile82Val Uncertain significance Single submitter
- TRMT1L p.Leu291Ser Uncertain significance Single submitter
- TRMT1L p.Leu315Pro Uncertain significance Single submitter
- TRMT1L p.Lys213Arg Uncertain significance Single submitter
- TRMT1L p.Lys275Asn Uncertain significance Single submitter
- TRMT1L p.Phe592Leu Uncertain significance Single submitter
- TRMT1L p.Pro11Ser Uncertain significance Single submitter
- TRMT1L p.Pro169Leu Uncertain significance Single submitter
- TRMT1L p.Pro169Ser Uncertain significance Single submitter
- TRMT1L p.Pro240Thr Uncertain significance Single submitter
- TRMT1L p.Ser532Ala Uncertain significance Single submitter
- TRMT1L p.Thr192Lys Uncertain significance Single submitter
- TRMT1L p.Thr304Lys Uncertain significance Single submitter
- TRMT1L p.Thr478Ala Uncertain significance Single submitter
- TRMT1L p.Thr600Ala Uncertain significance Single submitter
- TRMT1L p.Thr697Ala Uncertain significance Single submitter
- TRMT1L p.Tyr657Cys Uncertain significance Single submitter
- TRMT1L p.Val313Leu Uncertain significance Single submitter
- TRMT1L p.Val462Gly Uncertain significance Single submitter
- TRMT1L p.Val675Ile Uncertain significance Single submitter
- TRMT1L p.Val717Ala Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- TRMT1L p.Ala443Ser Uncertain significance Single submitter
- TRMT1L p.Ala444Thr Uncertain significance Single submitter
- TRMT1L p.Ala50Thr Uncertain significance Single submitter
- TRMT1L p.Ala50Val Uncertain significance Single submitter
- TRMT1L p.Ala54Ser Uncertain significance Single submitter
- TRMT1L p.Ala56Asp Uncertain significance Single submitter
- TRMT1L p.Ala64Thr Uncertain significance Single submitter
- TRMT1L p.Ala72Pro Uncertain significance Single submitter
- TRMT1L p.Asp233His Uncertain significance Single submitter
- TRMT1L p.Cys132Tyr Uncertain significance Single submitter
- TRMT1L p.Ile389Met Uncertain significance Single submitter
- TRMT1L p.Ile389Thr Uncertain significance Single submitter
- TRMT1L p.Lys128Asn Uncertain significance Single submitter
- TRMT1L p.Lys428Glu Uncertain significance Single submitter
- TRMT1L p.Pro245Ser Uncertain significance Single submitter
- TRMT1L p.Pro37Leu Uncertain significance Single submitter
- TRMT1L p.Pro37Ser Uncertain significance Single submitter
- TRMT1L p.Pro472Ser Uncertain significance Single submitter
- TRMT1L p.Pro63Ala Uncertain significance Single submitter
- TRMT1L p.Pro67Ala Uncertain significance Single submitter
- TRMT1L p.Pro694Thr Uncertain significance Single submitter
- TRMT1L p.Pro73Arg Uncertain significance Single submitter
- TRMT1L p.Ser71Cys Uncertain significance Single submitter
- TRMT1L p.Ser71Phe Uncertain significance Single submitter
- TRMT1L p.Val24Phe Uncertain significance Single submitter
- TRMT1L p.Val466Leu Uncertain significance Single submitter
All TRMT1L variants
Likely benign 3
- p.Ala222Val Single submitter
- p.Ile244Val Single submitter
- p.Lys336Glu Single submitter
Uncertain significance 76
- p.Ala105Val Single submitter ⚠
- p.Ala120Pro Single submitter ⚠
- p.Ala120Thr Single submitter ⚠
- p.Ala271Ser Single submitter ⚠
- p.Ala385Ser Single submitter ⚠
- p.Ala443Ser Single submitter ⚠
- p.Ala444Thr Single submitter ⚠
- p.Ala479Thr Single submitter ⚠
- p.Ala50Thr Single submitter ⚠
- p.Ala50Val Single submitter ⚠
- p.Ala54Ser Single submitter ⚠
- p.Ala56Asp Single submitter ⚠
- p.Ala5Val Single submitter ⚠
- p.Ala64Thr Single submitter ⚠
- p.Ala679Pro Single submitter ⚠
- p.Ala72Pro Single submitter ⚠
- p.Ala76Ser Single submitter ⚠
- p.Arg165Gln Single submitter ⚠
- p.Arg260Trp Single submitter ⚠
- p.Arg509Gly Single submitter ⚠
- p.Asn350Ser Single submitter ⚠
- p.Asn350Thr Single submitter ⚠
- p.Asn3Lys Single submitter ⚠
- p.Asn584Ser Single submitter ⚠
- p.Asp233His Single submitter ⚠
- p.Asp499Glu Single submitter ⚠
- p.Asp723Asn Single submitter ⚠
- p.Cys132Tyr Single submitter ⚠
- p.Gln237Glu Single submitter ⚠
- p.Glu16Val Single submitter ⚠
- p.Gly620Ser Single submitter ⚠
- p.His202Tyr Single submitter ⚠
- p.His296Leu Single submitter ⚠
- p.Ile288Val Single submitter ⚠
- p.Ile305Val Single submitter ⚠
- p.Ile340Thr Single submitter ⚠
- p.Ile389Met Single submitter ⚠
- p.Ile389Thr Single submitter ⚠
- p.Ile389Val Single submitter ⚠
- p.Ile577Thr Single submitter ⚠
- p.Ile593Asn Single submitter ⚠
- p.Ile82Val Single submitter ⚠
- p.Leu291Ser Single submitter ⚠
- p.Leu315Pro Single submitter ⚠
- p.Lys128Asn Single submitter ⚠
- p.Lys213Arg Single submitter ⚠
- p.Lys275Asn Single submitter ⚠
- p.Lys428Glu Single submitter ⚠
- p.Phe592Leu Single submitter ⚠
- p.Pro11Ser Single submitter ⚠
- p.Pro169Leu Single submitter ⚠
- p.Pro169Ser Single submitter ⚠
- p.Pro240Thr Single submitter ⚠
- p.Pro245Ser Single submitter ⚠
- p.Pro37Leu Single submitter ⚠
- p.Pro37Ser Single submitter ⚠
- p.Pro472Ser Single submitter ⚠
- p.Pro63Ala Single submitter ⚠
- p.Pro67Ala Single submitter ⚠
- p.Pro694Thr Single submitter ⚠
- p.Pro73Arg Single submitter ⚠
- p.Ser532Ala Single submitter ⚠
- p.Ser71Cys Single submitter ⚠
- p.Ser71Phe Single submitter ⚠
- p.Thr192Lys Single submitter ⚠
- p.Thr304Lys Single submitter ⚠
- p.Thr478Ala Single submitter ⚠
- p.Thr600Ala Single submitter ⚠
- p.Thr697Ala Single submitter ⚠
- p.Tyr657Cys Single submitter ⚠
- p.Val24Phe Single submitter ⚠
- p.Val313Leu Single submitter ⚠
- p.Val462Gly Single submitter ⚠
- p.Val466Leu Single submitter ⚠
- p.Val675Ile Single submitter ⚠
- p.Val717Ala Single submitter ⚠