TRPM8 — 157 ClinVar variants
All ClinVar germline TRPM8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 131 flagged for review →
8 Benign · 8 Likely benign · 141 Uncertain significance
Full TRPM8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 131
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 98
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TRPM8 p.Ala1071Pro Uncertain significance Single submitter
- TRPM8 p.Ala1071Val Uncertain significance Single submitter
- TRPM8 p.Ala172Thr Uncertain significance Single submitter
- TRPM8 p.Ala275Glu Uncertain significance Single submitter
- TRPM8 p.Ala28Thr Uncertain significance Single submitter
- TRPM8 p.Ala336Thr Uncertain significance Single submitter
- TRPM8 p.Ala5Glu Uncertain significance Single submitter
- TRPM8 p.Ala640Pro Uncertain significance Single submitter
- TRPM8 p.Ala670Ser Uncertain significance Single submitter
- TRPM8 p.Ala811Thr Uncertain significance Single submitter
- TRPM8 p.Arg1081Leu Uncertain significance Single submitter
- TRPM8 p.Arg22Gln Uncertain significance Single submitter
- TRPM8 p.Arg278Trp Uncertain significance Single submitter
- TRPM8 p.Arg360His Uncertain significance Single submitter
- TRPM8 p.Arg452Gln Uncertain significance Single submitter
- TRPM8 p.Arg507Gln Uncertain significance Single submitter
- TRPM8 p.Arg507Trp Uncertain significance Single submitter
- TRPM8 p.Arg52Gln Uncertain significance Single submitter
- TRPM8 p.Arg532Gln Uncertain significance Single submitter
- TRPM8 p.Arg536Trp Uncertain significance Single submitter
- TRPM8 p.Arg543Gln Uncertain significance Single submitter
- TRPM8 p.Arg543Trp Uncertain significance Single submitter
- TRPM8 p.Arg558Gln Uncertain significance Single submitter
- TRPM8 p.Arg558Trp Uncertain significance Single submitter
- TRPM8 p.Arg998Thr Uncertain significance Single submitter
- TRPM8 p.Asn1050Ser Uncertain significance Single submitter
- TRPM8 p.Asn222Lys Uncertain significance Single submitter
- TRPM8 p.Asn443Lys Uncertain significance Single submitter
- TRPM8 p.Asn792Ser Uncertain significance Single submitter
- TRPM8 p.Asn968Ile Uncertain significance Single submitter
- TRPM8 p.Asp101Asn Uncertain significance Single submitter
- TRPM8 p.Asp424Gly Uncertain significance Single submitter
- TRPM8 p.Asp539Glu Uncertain significance Single submitter
- TRPM8 p.Asp539His Uncertain significance Single submitter
- TRPM8 p.Asp552Glu Uncertain significance Single submitter
- TRPM8 p.Cys961Tyr Uncertain significance Single submitter
- TRPM8 p.Gln992Arg Uncertain significance Single submitter
- TRPM8 p.Glu127Asp Uncertain significance Single submitter
- TRPM8 p.Glu127Gly Uncertain significance Single submitter
- TRPM8 p.Glu274Lys Uncertain significance Single submitter
- TRPM8 p.Glu356Gln Uncertain significance Single submitter
- TRPM8 p.Glu386Lys Uncertain significance Single submitter
- TRPM8 p.Glu65Gln Uncertain significance Single submitter
- TRPM8 p.Glu79Gly Uncertain significance Single submitter
- TRPM8 p.Gly193Arg Uncertain significance Single submitter
- TRPM8 p.Gly218Asp Uncertain significance Single submitter
- TRPM8 p.Gly542Val Uncertain significance Single submitter
- TRPM8 p.His389Gln Uncertain significance Single submitter
- TRPM8 p.His500Asn Uncertain significance Single submitter
- TRPM8 p.His765Gln Uncertain significance Single submitter
- TRPM8 p.Ile192Val Uncertain significance Single submitter
- TRPM8 p.Ile212Thr Uncertain significance Single submitter
- TRPM8 p.Ile301Thr Uncertain significance Single submitter
- TRPM8 p.Ile548Thr Uncertain significance Single submitter
- TRPM8 p.Ile695Thr Uncertain significance Single submitter
- TRPM8 p.Ile702Met Uncertain significance Single submitter
- TRPM8 p.Ile746Val Uncertain significance Single submitter
- TRPM8 p.Ile957Asn Uncertain significance Single submitter
- TRPM8 p.Leu1001Pro Uncertain significance Single submitter
- TRPM8 p.Leu24Gln Uncertain significance Single submitter
- TRPM8 p.Leu41Ser Uncertain significance Single submitter
- TRPM8 p.Leu430Pro Uncertain significance Single submitter
- TRPM8 p.Leu430Val Uncertain significance Single submitter
- TRPM8 p.Leu550His Uncertain significance Single submitter
- TRPM8 p.Leu825Phe Uncertain significance Single submitter
- TRPM8 p.Leu939Met Uncertain significance Single submitter
- TRPM8 p.Lys1104Glu Uncertain significance Single submitter
- TRPM8 p.Lys190Arg Uncertain significance Single submitter
- TRPM8 p.Lys472Arg Uncertain significance Single submitter
- TRPM8 p.Lys691Asn Uncertain significance Single submitter
- TRPM8 p.Met219Leu Uncertain significance Single submitter
- TRPM8 p.Phe165Ser Uncertain significance Single submitter
- TRPM8 p.Phe236Val Uncertain significance Single submitter
- TRPM8 p.Phe881Ser Uncertain significance Single submitter
- TRPM8 p.Pro767Arg Uncertain significance Single submitter
- TRPM8 p.Pro855Leu Uncertain significance Single submitter
- TRPM8 p.Ser332Leu Uncertain significance Single submitter
- TRPM8 p.Ser376Arg Uncertain significance Single submitter
- TRPM8 p.Ser376Asn Uncertain significance Single submitter
- TRPM8 p.Ser820Phe Uncertain significance Single submitter
- TRPM8 p.Thr1069Ala Uncertain significance Single submitter
- TRPM8 p.Thr1069Arg Uncertain significance Single submitter
- TRPM8 p.Thr23Pro Uncertain significance Single submitter
- TRPM8 p.Thr374Ile Uncertain significance Single submitter
- TRPM8 p.Thr464Met Uncertain significance Single submitter
- TRPM8 p.Thr494Ala Uncertain significance Single submitter
- TRPM8 p.Thr494Ile Uncertain significance Single submitter
- TRPM8 p.Thr503Met Uncertain significance Single submitter
- TRPM8 p.Thr732Ala Uncertain significance Single submitter
- TRPM8 p.Thr803Met Uncertain significance Single submitter
- TRPM8 p.Trp954Arg Uncertain significance Single submitter
- TRPM8 p.Tyr1022Cys Uncertain significance Single submitter
- TRPM8 p.Tyr191Cys Uncertain significance Single submitter
- TRPM8 p.Val1025Leu Uncertain significance Single submitter
- TRPM8 p.Val263Met Uncertain significance Single submitter
- TRPM8 p.Val55Ile Uncertain significance Single submitter
- TRPM8 p.Val791Met Uncertain significance Single submitter
- TRPM8 p.Val814Ile Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- TRPM8 p.Met462Thr Benign Multiple submitters
- TRPM8 p.Ala753Thr Uncertain significance Single submitter
- TRPM8 p.Arg223Trp Uncertain significance Single submitter
- TRPM8 p.Arg451Ser Uncertain significance Single submitter
- TRPM8 p.Asn968His Uncertain significance Single submitter
- TRPM8 p.Asn968Lys Uncertain significance Single submitter
- TRPM8 p.Asn968Thr Uncertain significance Single submitter
- TRPM8 p.Asn989Lys Uncertain significance Single submitter
- TRPM8 p.Asp198Glu Uncertain significance Single submitter
- TRPM8 p.Asp925Glu Uncertain significance Single submitter
- TRPM8 p.Cys587Arg Uncertain significance Single submitter
- TRPM8 p.Cys648Tyr Uncertain significance Single submitter
- TRPM8 p.Gln671His Uncertain significance Single submitter
- TRPM8 p.Glu906Lys Uncertain significance Single submitter
- TRPM8 p.Gly1057Arg Uncertain significance Single submitter
- TRPM8 p.Gly297Arg Uncertain significance Single submitter
- TRPM8 p.Gly652Cys Uncertain significance Single submitter
- TRPM8 p.Gly790Arg Uncertain significance Single submitter
- TRPM8 p.Gly913Ser Uncertain significance Single submitter
- TRPM8 p.Ile106Met Uncertain significance Single submitter
- TRPM8 p.Ile1099Thr Uncertain significance Single submitter
- TRPM8 p.Leu439Pro Uncertain significance Single submitter
- TRPM8 p.Lys163Thr Uncertain significance Single submitter
- TRPM8 p.Met161Thr Uncertain significance Single submitter
- TRPM8 p.Met859Val Uncertain significance Single submitter
- TRPM8 p.Pro159Leu Uncertain significance Single submitter
- TRPM8 p.Pro958Thr Uncertain significance Single submitter
- TRPM8 p.Thr100Ser Uncertain significance Single submitter
- TRPM8 p.Thr489Ile Uncertain significance Single submitter
- TRPM8 p.Thr95Ala Uncertain significance Single submitter
- TRPM8 p.Tyr808His Uncertain significance Single submitter
- TRPM8 p.Tyr963Phe Uncertain significance Single submitter
- TRPM8 p.Val196Ala Uncertain significance Single submitter
All TRPM8 variants
Benign 8
- p.Arg247Thr Multiple submitters
- p.Asn821Ser Multiple submitters
- p.Glu545= Multiple submitters
- p.Leu226= Multiple submitters
- p.Met462Thr Multiple submitters ⚠
- p.Pro916= Multiple submitters
- c.1362+10A>C Single submitter
- p.Tyr410= Single submitter
Likely benign 8
- c.1363-8C>T Single submitter
- c.1880-7G>A Single submitter
- p.Arg4= Single submitter
- p.Asp450= Single submitter
- p.Gly542Ser Single submitter
- p.Ile1016Val Single submitter
- p.Pro766Thr Single submitter
- p.Val42= Single submitter
Uncertain significance 141
- p.Ala1071Pro Single submitter ⚠
- p.Ala1071Val Single submitter ⚠
- p.Ala172Thr Single submitter ⚠
- p.Ala215Val Single submitter
- p.Ala275Glu Single submitter ⚠
- p.Ala28Thr Single submitter ⚠
- p.Ala336Thr Single submitter ⚠
- p.Ala5Glu Single submitter ⚠
- p.Ala640Pro Single submitter ⚠
- p.Ala670Ser Single submitter ⚠
- p.Ala753Thr Single submitter ⚠
- p.Ala811Thr Single submitter ⚠
- p.Arg1081Leu Single submitter ⚠
- p.Arg223Trp Single submitter ⚠
- p.Arg22Gln Single submitter ⚠
- p.Arg278Trp Single submitter ⚠
- p.Arg360His Single submitter ⚠
- p.Arg451Ser Single submitter ⚠
- p.Arg452Gln Single submitter ⚠
- p.Arg452Ter Single submitter
- p.Arg507Gln Single submitter ⚠
- p.Arg507Trp Single submitter ⚠
- p.Arg52Gln Single submitter ⚠
- p.Arg532Gln Single submitter ⚠
- p.Arg536Trp Single submitter ⚠
- p.Arg543Gln Single submitter ⚠
- p.Arg543Trp Single submitter ⚠
- p.Arg558Gln Single submitter ⚠
- p.Arg558Trp Single submitter ⚠
- p.Arg998Thr Single submitter ⚠
- p.Asn1050Ser Single submitter ⚠
- p.Asn222Lys Single submitter ⚠
- p.Asn222Tyr Single submitter
- p.Asn443Lys Single submitter ⚠
- p.Asn792Ser Single submitter ⚠
- p.Asn968His Single submitter ⚠
- p.Asn968Ile Single submitter ⚠
- p.Asn968Lys Single submitter ⚠
- p.Asn968Thr Single submitter ⚠
- p.Asn989Lys Single submitter ⚠
- p.Asp101Asn Single submitter ⚠
- p.Asp198Glu Single submitter ⚠
- p.Asp424Gly Single submitter ⚠
- p.Asp539Glu Single submitter ⚠
- p.Asp539His Single submitter ⚠
- p.Asp552Glu Single submitter ⚠
- p.Asp925Glu Single submitter ⚠
- p.Cys587Arg Single submitter ⚠
- p.Cys648Tyr Single submitter ⚠
- p.Cys961Tyr Single submitter ⚠
- p.Gln671His Single submitter ⚠
- p.Gln992Arg Single submitter ⚠
- p.Glu127Asp Single submitter ⚠
- p.Glu127Gly Single submitter ⚠
- p.Glu274Lys Single submitter ⚠
- p.Glu356Gln Single submitter ⚠
- p.Glu386Lys Single submitter ⚠
- p.Glu402Gly Single submitter
- p.Glu65Gln Single submitter ⚠
- p.Glu79Gly Single submitter ⚠
- p.Glu906Lys Single submitter ⚠
- p.Glu935Gly Single submitter
- p.Gly1057Arg Single submitter ⚠
- p.Gly193Arg Single submitter ⚠
- p.Gly218Asp Single submitter ⚠
- p.Gly297Arg Single submitter ⚠
- p.Gly297Val Single submitter
- p.Gly542Val Single submitter ⚠
- p.Gly652Cys Single submitter ⚠
- p.Gly790Arg Single submitter ⚠
- p.Gly913Ser Single submitter ⚠
- p.His389Gln Single submitter ⚠
- p.His500Asn Single submitter ⚠
- p.His765Gln Single submitter ⚠
- p.Ile106Met Single submitter ⚠
- p.Ile1099Thr Single submitter ⚠
- p.Ile192Thr Single submitter
- p.Ile192Val Single submitter ⚠
- p.Ile212Thr Single submitter ⚠
- p.Ile301Thr Single submitter ⚠
- p.Ile548Thr Single submitter ⚠
- p.Ile695Thr Single submitter ⚠
- p.Ile702Met Single submitter ⚠
- p.Ile746Val Single submitter ⚠
- p.Ile957Asn Single submitter ⚠
- p.Leu1001Pro Single submitter ⚠
- p.Leu24Gln Single submitter ⚠
- p.Leu41Ser Single submitter ⚠
- p.Leu430Pro Single submitter ⚠
- p.Leu430Val Single submitter ⚠
- p.Leu439Pro Single submitter ⚠
- p.Leu550His Single submitter ⚠
- p.Leu825Phe Single submitter ⚠
- p.Leu939Met Single submitter ⚠
- p.Lys1104Glu Single submitter ⚠
- p.Lys163Thr Single submitter ⚠
- p.Lys190Arg Single submitter ⚠
- p.Lys472Arg Single submitter ⚠
- p.Lys691Asn Single submitter ⚠
- p.Met161Thr Single submitter ⚠
- p.Met219Leu Single submitter ⚠
- p.Met859Val Single submitter ⚠
- p.Phe165Cys Single submitter
- p.Phe165Ser Single submitter ⚠
- p.Phe236Val Single submitter ⚠
- p.Phe881Ser Single submitter ⚠
- p.Pro159Leu Single submitter ⚠
- p.Pro767Arg Single submitter ⚠
- p.Pro855Leu Single submitter ⚠
- p.Pro958Thr Single submitter ⚠
- p.Ser166Asn Single submitter
- p.Ser332Leu Single submitter ⚠
- p.Ser376Arg Single submitter ⚠
- p.Ser376Asn Single submitter ⚠
- p.Ser820Phe Single submitter ⚠
- p.Thr100Ser Single submitter ⚠
- p.Thr1069Ala Single submitter ⚠
- p.Thr1069Arg Single submitter ⚠
- p.Thr23Pro Single submitter ⚠
- p.Thr374Ile Single submitter ⚠
- p.Thr464Met Single submitter ⚠
- p.Thr489Ile Single submitter ⚠
- p.Thr494Ala Single submitter ⚠
- p.Thr494Ile Single submitter ⚠
- p.Thr503Met Single submitter ⚠
- p.Thr732Ala Single submitter ⚠
- p.Thr803Met Single submitter ⚠
- p.Thr95Ala Single submitter ⚠
- p.Trp954Arg Single submitter ⚠
- p.Tyr1020Cys Single submitter
- p.Tyr1020Ser Single submitter
- p.Tyr1022Cys Single submitter ⚠
- p.Tyr191Cys Single submitter ⚠
- p.Tyr808His Single submitter ⚠
- p.Tyr963Phe Single submitter ⚠
- p.Val1025Leu Single submitter ⚠
- p.Val196Ala Single submitter ⚠
- p.Val263Met Single submitter ⚠
- p.Val55Ile Single submitter ⚠
- p.Val791Met Single submitter ⚠
- p.Val814Ile Single submitter ⚠