TSNAX — 27 ClinVar variants
All ClinVar germline TSNAX variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
2 Benign · 25 Uncertain significance
Full TSNAX gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TSNAX p.Ala251Thr Uncertain significance Single submitter
- TSNAX p.Arg222Cys Uncertain significance Single submitter
- TSNAX p.Asn159Ser Uncertain significance Single submitter
- TSNAX p.Asp112Gly Uncertain significance Single submitter
- TSNAX p.Asp186Asn Uncertain significance Single submitter
- TSNAX p.Gln219Leu Uncertain significance Single submitter
- TSNAX p.Gln99Arg Uncertain significance Single submitter
- TSNAX p.Glu238Lys Uncertain significance Single submitter
- TSNAX p.Gly96Asp Uncertain significance Single submitter
- TSNAX p.Ile153Val Uncertain significance Single submitter
- TSNAX p.Ile86Thr Uncertain significance Single submitter
- TSNAX p.Met145Thr Uncertain significance Single submitter
- TSNAX p.Pro166Thr Uncertain significance Single submitter
- TSNAX p.Ser144Gly Uncertain significance Single submitter
- TSNAX p.Ser144Thr Uncertain significance Single submitter
- TSNAX p.Thr122Ile Uncertain significance Single submitter
- TSNAX p.Thr155Met Uncertain significance Single submitter
- TSNAX p.Thr234Ala Uncertain significance Single submitter
- TSNAX p.Thr78Ile Uncertain significance Single submitter
- TSNAX p.Val182Leu Uncertain significance Single submitter
- TSNAX p.Val57Gly Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All TSNAX variants
Benign 2
- c.368-8G>A Single submitter
- p.Lys150= Single submitter
Uncertain significance 25
- p.Ala251Thr Single submitter ⚠
- p.Arg222Cys Single submitter ⚠
- p.Arg222His Single submitter ⚠
- p.Asn159Ser Single submitter ⚠
- p.Asp112Gly Single submitter ⚠
- p.Asp186Asn Single submitter ⚠
- p.Gln219Leu Single submitter ⚠
- p.Gln99Arg Single submitter ⚠
- p.Glu238Lys Single submitter ⚠
- p.Gly96Asp Single submitter ⚠
- p.His270Arg Single submitter ⚠
- p.Ile137Phe Single submitter ⚠
- p.Ile153Val Single submitter ⚠
- p.Ile86Thr Single submitter ⚠
- p.Met145Thr Single submitter ⚠
- p.Pro166Thr Single submitter ⚠
- p.Ser144Gly Single submitter ⚠
- p.Ser144Thr Single submitter ⚠
- p.Thr122Ile Single submitter ⚠
- p.Thr155Met Single submitter ⚠
- p.Thr234Ala Single submitter ⚠
- p.Thr78Ile Single submitter ⚠
- p.Val182Leu Single submitter ⚠
- p.Val275Gly Single submitter ⚠
- p.Val57Gly Single submitter ⚠