TSSK3 — 46 ClinVar variants
All ClinVar germline TSSK3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
46 Uncertain significance
Full TSSK3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TSSK3 p.Ala91Thr Uncertain significance Single submitter
- TSSK3 p.Arg110Gln Uncertain significance Single submitter
- TSSK3 p.Arg116Cys Uncertain significance Single submitter
- TSSK3 p.Arg123His Uncertain significance Single submitter
- TSSK3 p.Arg163Gln Uncertain significance Single submitter
- TSSK3 p.Arg253Gln Uncertain significance Single submitter
- TSSK3 p.Arg34Lys Uncertain significance Single submitter
- TSSK3 p.Asn139Thr Uncertain significance Single submitter
- TSSK3 p.Asn69Ile Uncertain significance Single submitter
- TSSK3 p.Asn8Ser Uncertain significance Single submitter
- TSSK3 p.Asp237Asn Uncertain significance Single submitter
- TSSK3 p.Asp240Glu Uncertain significance Single submitter
- TSSK3 p.Cys170Ser Uncertain significance Single submitter
- TSSK3 p.Gln223Arg Uncertain significance Single submitter
- TSSK3 p.Glu179Lys Uncertain significance Single submitter
- TSSK3 p.Glu26Ala Uncertain significance Single submitter
- TSSK3 p.Gly171Ser Uncertain significance Single submitter
- TSSK3 p.Gly82Arg Uncertain significance Single submitter
- TSSK3 p.Gly94Trp Uncertain significance Single submitter
- TSSK3 p.His126Tyr Uncertain significance Single submitter
- TSSK3 p.Ile256Val Uncertain significance Single submitter
- TSSK3 p.Leu147Val Uncertain significance Single submitter
- TSSK3 p.Lys39Glu Uncertain significance Single submitter
- TSSK3 p.Lys68Glu Uncertain significance Single submitter
- TSSK3 p.Lys83Arg Uncertain significance Single submitter
- TSSK3 p.Met203Thr Uncertain significance Single submitter
- TSSK3 p.Met250Thr Uncertain significance Single submitter
- TSSK3 p.Met250Val Uncertain significance Single submitter
- TSSK3 p.Phe210Ser Uncertain significance Single submitter
- TSSK3 p.Pro47Thr Uncertain significance Single submitter
- TSSK3 p.Ser7Ala Uncertain significance Single submitter
- TSSK3 p.Trp264Arg Uncertain significance Single submitter
- TSSK3 p.Tyr74His Uncertain significance Single submitter
- TSSK3 p.Val119Ala Uncertain significance Single submitter
- TSSK3 p.Val130Ala Uncertain significance Single submitter
- TSSK3 p.Val62Ile Uncertain significance Single submitter
- TSSK3 p.Val73Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- TSSK3 p.Arg110Trp Uncertain significance Single submitter
- TSSK3 p.Arg116His Uncertain significance Single submitter
- TSSK3 p.Arg116Pro Uncertain significance Single submitter
- TSSK3 p.His186Gln Uncertain significance Single submitter
- TSSK3 p.His231Pro Uncertain significance Single submitter
- TSSK3 p.Phe169Ser Uncertain significance Single submitter
All TSSK3 variants
Uncertain significance 46
- p.Ala91Thr Single submitter ⚠
- p.Arg110Gln Single submitter ⚠
- p.Arg110Trp Single submitter ⚠
- p.Arg116Cys Single submitter ⚠
- p.Arg116His Single submitter ⚠
- p.Arg116Pro Single submitter ⚠
- p.Arg123His Single submitter ⚠
- p.Arg163Gln Single submitter ⚠
- p.Arg253Gln Single submitter ⚠
- p.Arg34Lys Single submitter ⚠
- p.Asn139Thr Single submitter ⚠
- p.Asn69Ile Single submitter ⚠
- p.Asn8Ser Single submitter ⚠
- p.Asp237Asn Single submitter ⚠
- p.Asp240Glu Single submitter ⚠
- p.Cys170Ser Single submitter ⚠
- p.Gln223Arg Single submitter ⚠
- p.Glu179Lys Single submitter ⚠
- p.Glu26Ala Single submitter ⚠
- p.Gly171Ser Single submitter ⚠
- p.Gly225Trp Single submitter
- p.Gly82Arg Single submitter ⚠
- p.Gly94Trp Single submitter ⚠
- p.His126Tyr Single submitter ⚠
- p.His186Gln Single submitter ⚠
- p.His231Pro Single submitter ⚠
- p.Ile16Thr Single submitter
- p.Ile256Val Single submitter ⚠
- p.Leu147Val Single submitter ⚠
- p.Lys39Glu Single submitter ⚠
- p.Lys68Glu Single submitter ⚠
- p.Lys83Arg Single submitter ⚠
- p.Met203Thr Single submitter ⚠
- p.Met250Thr Single submitter ⚠
- p.Met250Val Single submitter ⚠
- p.Phe169Ser Single submitter ⚠
- p.Phe210Ser Single submitter ⚠
- p.Pro47Thr Single submitter ⚠
- p.Ser235Leu Single submitter
- p.Ser7Ala Single submitter ⚠
- p.Trp264Arg Single submitter ⚠
- p.Tyr74His Single submitter ⚠
- p.Val119Ala Single submitter ⚠
- p.Val130Ala Single submitter ⚠
- p.Val62Ile Single submitter ⚠
- p.Val73Met Single submitter ⚠