TSSK6 — 22 ClinVar variants
All ClinVar germline TSSK6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
1 Likely benign · 21 Uncertain significance
Full TSSK6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TSSK6 p.Ala242Val Uncertain significance Single submitter
- TSSK6 p.Arg239Ser Uncertain significance Single submitter
- TSSK6 p.Asp166Ala Uncertain significance Single submitter
- TSSK6 p.Glu181Lys Uncertain significance Single submitter
- TSSK6 p.Glu246Lys Uncertain significance Single submitter
- TSSK6 p.Gly105Arg Uncertain significance Single submitter
- TSSK6 p.Gly156Ser Uncertain significance Single submitter
- TSSK6 p.His130Gln Uncertain significance Single submitter
- TSSK6 p.His74Gln Uncertain significance Single submitter
- TSSK6 p.Leu10Ile Uncertain significance Single submitter
- TSSK6 p.Leu167Val Uncertain significance Single submitter
- TSSK6 p.Lys151Arg Uncertain significance Single submitter
- TSSK6 p.Met90Ile Uncertain significance Single submitter
- TSSK6 p.Pro145Arg Uncertain significance Single submitter
- TSSK6 p.Pro252Ala Uncertain significance Single submitter
- TSSK6 p.Val195Gly Uncertain significance Single submitter
- TSSK6 p.Val67Met Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All TSSK6 variants
Likely benign 1
- p.Leu202= Single submitter
Uncertain significance 21
- p.Ala242Val Single submitter ⚠
- p.Ala48Val Single submitter ⚠
- p.Arg223His Single submitter ⚠
- p.Arg239Ser Single submitter ⚠
- p.Asp166Ala Single submitter ⚠
- p.Glu181Lys Single submitter ⚠
- p.Glu246Lys Single submitter ⚠
- p.Gly105Arg Single submitter ⚠
- p.Gly156Ser Single submitter ⚠
- p.Gly227Ser Single submitter ⚠
- p.Gly84Arg Single submitter ⚠
- p.His130Gln Single submitter ⚠
- p.His74Gln Single submitter ⚠
- p.Leu10Ile Single submitter ⚠
- p.Leu167Val Single submitter ⚠
- p.Lys151Arg Single submitter ⚠
- p.Met90Ile Single submitter ⚠
- p.Pro145Arg Single submitter ⚠
- p.Pro252Ala Single submitter ⚠
- p.Val195Gly Single submitter ⚠
- p.Val67Met Single submitter ⚠