TST — 49 ClinVar variants
All ClinVar germline TST variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
3 Likely benign · 46 Uncertain significance
Full TST gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TST p.Arg183Ser Uncertain significance Single submitter
- TST p.Arg187Leu Uncertain significance Single submitter
- TST p.Arg30Gly Uncertain significance Single submitter
- TST p.Asn133Ser Uncertain significance Single submitter
- TST p.Asp268Glu Uncertain significance Single submitter
- TST p.Asp33Gly Uncertain significance Single submitter
- TST p.Glu47Gly Uncertain significance Single submitter
- TST p.Glu72Lys Uncertain significance Single submitter
- TST p.Gly130Ala Uncertain significance Single submitter
- TST p.Gly55Ser Uncertain significance Single submitter
- TST p.Met211Leu Uncertain significance Single submitter
- TST p.Phe213Leu Uncertain significance Single submitter
- TST p.Phe216Cys Uncertain significance Single submitter
- TST p.Pro193Gln Uncertain significance Single submitter
- TST p.Pro285Gln Uncertain significance Single submitter
- TST p.Thr164Ile Uncertain significance Single submitter
- TST p.Val252Ile Uncertain significance Single submitter
- TST p.Val257Met Uncertain significance Single submitter
- TST p.Val31Gly Uncertain significance Single submitter
- TST p.Val53Ile Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- TST p.Arg132Trp Uncertain significance Single submitter
- TST p.Arg206His Uncertain significance Single submitter
- TST p.Arg230Cys Uncertain significance Single submitter
- TST p.Arg230His Uncertain significance Single submitter
- TST p.Arg249Cys Uncertain significance Single submitter
- TST p.Arg282Gln Uncertain significance Single submitter
- TST p.Arg282Trp Uncertain significance Single submitter
- TST p.Arg288His Uncertain significance Single submitter
- TST p.Arg45Leu Uncertain significance Single submitter
- TST p.Arg51His Uncertain significance Single submitter
- TST p.Glu137Lys Uncertain significance Single submitter
- TST p.Gly186Glu Uncertain significance Single submitter
- TST p.Gly265Ser Uncertain significance Single submitter
- TST p.Gly28Val Uncertain significance Single submitter
- TST p.Lys236Thr Uncertain significance Single submitter
- TST p.Pro150Ser Uncertain significance Single submitter
- TST p.Pro195Leu Uncertain significance Single submitter
- TST p.Pro284Thr Uncertain significance Single submitter
- TST p.Ser202Leu Uncertain significance Single submitter
- TST p.Ser241Leu Uncertain significance Single submitter
- TST p.Ser77Arg Uncertain significance Single submitter
- TST p.Thr247Met Uncertain significance Single submitter
- TST p.Thr94Met Uncertain significance Single submitter
- TST p.Val124Ile Uncertain significance Single submitter
- TST p.Val152Phe Uncertain significance Single submitter
- TST p.Val271Met Uncertain significance Single submitter
All TST variants
Likely benign 3
- c.595+9C>T Single submitter
- p.Ala151= Single submitter
- p.Arg281His Single submitter
Uncertain significance 46
- p.Arg132Trp Single submitter ⚠
- p.Arg183Ser Single submitter ⚠
- p.Arg187Leu Single submitter ⚠
- p.Arg206His Single submitter ⚠
- p.Arg230Cys Single submitter ⚠
- p.Arg230His Single submitter ⚠
- p.Arg249Cys Single submitter ⚠
- p.Arg282Gln Single submitter ⚠
- p.Arg282Trp Single submitter ⚠
- p.Arg288His Single submitter ⚠
- p.Arg30Gly Single submitter ⚠
- p.Arg45Leu Single submitter ⚠
- p.Arg51His Single submitter ⚠
- p.Asn133Ser Single submitter ⚠
- p.Asp268Glu Single submitter ⚠
- p.Asp33Gly Single submitter ⚠
- p.Glu137Lys Single submitter ⚠
- p.Glu47Gly Single submitter ⚠
- p.Glu72Lys Single submitter ⚠
- p.Gly130Ala Single submitter ⚠
- p.Gly186Glu Single submitter ⚠
- p.Gly265Ser Single submitter ⚠
- p.Gly28Val Single submitter ⚠
- p.Gly55Ser Single submitter ⚠
- p.Lys236Thr Single submitter ⚠
- p.Met211Leu Single submitter ⚠
- p.Phe213Leu Single submitter ⚠
- p.Phe216Cys Single submitter ⚠
- p.Pro150Ser Single submitter ⚠
- p.Pro193Gln Single submitter ⚠
- p.Pro195Leu Single submitter ⚠
- p.Pro284Thr Single submitter ⚠
- p.Pro285Gln Single submitter ⚠
- p.Ser202Leu Single submitter ⚠
- p.Ser241Leu Single submitter ⚠
- p.Ser77Arg Single submitter ⚠
- p.Thr164Ile Single submitter ⚠
- p.Thr247Met Single submitter ⚠
- p.Thr94Met Single submitter ⚠
- p.Val124Ile Single submitter ⚠
- p.Val152Phe Single submitter ⚠
- p.Val252Ile Single submitter ⚠
- p.Val257Met Single submitter ⚠
- p.Val271Met Single submitter ⚠
- p.Val31Gly Single submitter ⚠
- p.Val53Ile Single submitter ⚠