TUBA1C — 40 ClinVar variants
All ClinVar germline TUBA1C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
4 Likely benign · 36 Uncertain significance
Full TUBA1C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TUBA1C p.Ala387Thr Uncertain significance Single submitter
- TUBA1C p.Arg123His Uncertain significance Single submitter
- TUBA1C p.Arg156Cys Uncertain significance Single submitter
- TUBA1C p.Arg264Cys Uncertain significance Single submitter
- TUBA1C p.Arg308Cys Uncertain significance Single submitter
- TUBA1C p.Arg320His Uncertain significance Single submitter
- TUBA1C p.Arg339Cys Uncertain significance Single submitter
- TUBA1C p.Asp160Gly Uncertain significance Single submitter
- TUBA1C p.Asp322Glu Uncertain significance Single submitter
- TUBA1C p.Cys4Phe Uncertain significance Single submitter
- TUBA1C p.Gln358Glu Uncertain significance Single submitter
- TUBA1C p.Glu113Ala Uncertain significance Single submitter
- TUBA1C p.Gly29Ser Uncertain significance Single submitter
- TUBA1C p.Gly43Val Uncertain significance Single submitter
- TUBA1C p.Ile16Thr Uncertain significance Single submitter
- TUBA1C p.Ile231Val Uncertain significance Single submitter
- TUBA1C p.Ile7Val Uncertain significance Single submitter
- TUBA1C p.Leu217Ile Uncertain significance Single submitter
- TUBA1C p.Lys401Thr Uncertain significance Single submitter
- TUBA1C p.Met425Arg Uncertain significance Single submitter
- TUBA1C p.Pro261Arg Uncertain significance Single submitter
- TUBA1C p.Pro359Ser Uncertain significance Single submitter
- TUBA1C p.Ser151Trp Uncertain significance Single submitter
- TUBA1C p.Thr253Arg Uncertain significance Single submitter
- TUBA1C p.Thr340Ala Uncertain significance Single submitter
- TUBA1C p.Val118Met Uncertain significance Single submitter
- TUBA1C p.Val405Ala Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- TUBA1C p.Gly43Ala Uncertain significance Single submitter
- TUBA1C p.Ile212Leu Uncertain significance Single submitter
- TUBA1C p.Ile5Leu Uncertain significance Single submitter
- TUBA1C p.Leu117Phe Uncertain significance Single submitter
- TUBA1C p.Leu317Val Uncertain significance Single submitter
- TUBA1C p.Thr334Ala Uncertain significance Single submitter
- TUBA1C p.Val14Ile Uncertain significance Single submitter
All TUBA1C variants
Likely benign 4
- c.-465C>T Single submitter
- p.Arg221= Single submitter
- p.Arg390= Single submitter
- p.Val384Ile Single submitter
Uncertain significance 36
- p.Ala387Thr Single submitter ⚠
- p.Arg123His Single submitter ⚠
- p.Arg156Cys Single submitter ⚠
- p.Arg214Cys Single submitter
- p.Arg264Cys Single submitter ⚠
- p.Arg308Cys Single submitter ⚠
- p.Arg320His Single submitter ⚠
- p.Arg339Cys Single submitter ⚠
- p.Asp160Gly Single submitter ⚠
- p.Asp322Glu Single submitter ⚠
- p.Cys4Phe Single submitter ⚠
- p.Gln358Glu Single submitter ⚠
- p.Glu113Ala Single submitter ⚠
- p.Gly29Ser Single submitter ⚠
- p.Gly43Ala Single submitter ⚠
- p.Gly43Val Single submitter ⚠
- p.Gly442Arg Single submitter
- p.Ile16Thr Single submitter ⚠
- p.Ile212Leu Single submitter ⚠
- p.Ile231Val Single submitter ⚠
- p.Ile5Leu Single submitter ⚠
- p.Ile7Val Single submitter ⚠
- p.Leu117Phe Single submitter ⚠
- p.Leu217Ile Single submitter ⚠
- p.Leu317Val Single submitter ⚠
- p.Lys401Thr Single submitter ⚠
- p.Met425Arg Single submitter ⚠
- p.Pro261Arg Single submitter ⚠
- p.Pro359Ser Single submitter ⚠
- p.Ser151Trp Single submitter ⚠
- p.Thr253Arg Single submitter ⚠
- p.Thr334Ala Single submitter ⚠
- p.Thr340Ala Single submitter ⚠
- p.Val118Met Single submitter ⚠
- p.Val14Ile Single submitter ⚠
- p.Val405Ala Single submitter ⚠