TWF2 — 40 ClinVar variants
All ClinVar germline TWF2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
2 Likely benign · 38 Uncertain significance
Full TWF2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TWF2 p.Ala145Val Uncertain significance Single submitter
- TWF2 p.Ala18Val Uncertain significance Single submitter
- TWF2 p.Ala292Thr Uncertain significance Single submitter
- TWF2 p.Ala87Thr Uncertain significance Single submitter
- TWF2 p.Arg188Trp Uncertain significance Single submitter
- TWF2 p.Arg231Gln Uncertain significance Single submitter
- TWF2 p.Arg235Cys Uncertain significance Single submitter
- TWF2 p.Arg235His Uncertain significance Single submitter
- TWF2 p.Arg278Cys Uncertain significance Single submitter
- TWF2 p.Arg340His Uncertain significance Single submitter
- TWF2 p.Arg48Gly Uncertain significance Single submitter
- TWF2 p.Arg48His Uncertain significance Single submitter
- TWF2 p.Arg72Leu Uncertain significance Single submitter
- TWF2 p.Asp347Gly Uncertain significance Single submitter
- TWF2 p.Cys141Arg Uncertain significance Single submitter
- TWF2 p.Glu208Gln Uncertain significance Single submitter
- TWF2 p.Gly114Ala Uncertain significance Single submitter
- TWF2 p.His288Asn Uncertain significance Single submitter
- TWF2 p.Ile117Val Uncertain significance Single submitter
- TWF2 p.Ile295Val Uncertain significance Single submitter
- TWF2 p.Lys263Met Uncertain significance Single submitter
- TWF2 p.Lys29Glu Uncertain significance Single submitter
- TWF2 p.Lys336Arg Uncertain significance Single submitter
- TWF2 p.Phe287Ile Uncertain significance Single submitter
- TWF2 p.Phe319Ile Uncertain significance Single submitter
- TWF2 p.Ser139Leu Uncertain significance Single submitter
- TWF2 p.Ser349Ile Uncertain significance Single submitter
- TWF2 p.Trp83Arg Uncertain significance Single submitter
- TWF2 p.Tyr236Cys Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- TWF2 p.Arg158Cys Uncertain significance Single submitter
- TWF2 p.Arg209Trp Uncertain significance Single submitter
- TWF2 p.Gln43Pro Uncertain significance Single submitter
- TWF2 p.Phe16Leu Uncertain significance Single submitter
- TWF2 p.Phe180Leu Uncertain significance Single submitter
- TWF2 p.Phe307Leu Uncertain significance Single submitter
- TWF2 p.Tyr71Cys Uncertain significance Single submitter
All TWF2 variants
Likely benign 2
- p.Ala292Ser Single submitter
- p.Pro342= Single submitter
Uncertain significance 38
- p.Ala145Val Single submitter ⚠
- p.Ala18Val Single submitter ⚠
- p.Ala292Thr Single submitter ⚠
- p.Ala87Thr Single submitter ⚠
- p.Arg158Cys Single submitter ⚠
- p.Arg188Trp Single submitter ⚠
- p.Arg209Trp Single submitter ⚠
- p.Arg231Gln Single submitter ⚠
- p.Arg235Cys Single submitter ⚠
- p.Arg235His Single submitter ⚠
- p.Arg278Cys Single submitter ⚠
- p.Arg340His Single submitter ⚠
- p.Arg48Gly Single submitter ⚠
- p.Arg48His Single submitter ⚠
- p.Arg72Leu Single submitter ⚠
- p.Asp347Gly Single submitter ⚠
- p.Cys141Arg Single submitter ⚠
- p.Gln43Pro Single submitter ⚠
- p.Glu208Gln Single submitter ⚠
- p.Glu82Ter Single submitter
- p.Gly114Ala Single submitter ⚠
- p.His288Asn Single submitter ⚠
- p.Ile117Val Single submitter ⚠
- p.Ile295Val Single submitter ⚠
- p.Lys263Met Single submitter ⚠
- p.Lys29Glu Single submitter ⚠
- p.Lys336Arg Single submitter ⚠
- p.Phe16Leu Single submitter ⚠
- p.Phe180Leu Single submitter ⚠
- p.Phe287Ile Single submitter ⚠
- p.Phe307Leu Single submitter ⚠
- p.Phe319Ile Single submitter ⚠
- p.Pro181Leu Single submitter
- p.Ser139Leu Single submitter ⚠
- p.Ser349Ile Single submitter ⚠
- p.Trp83Arg Single submitter ⚠
- p.Tyr236Cys Single submitter ⚠
- p.Tyr71Cys Single submitter ⚠