TXNL1 — 28 ClinVar variants
All ClinVar germline TXNL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
2 Benign · 1 Likely benign · 25 Uncertain significance
Full TXNL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TXNL1 p.Ala25Thr Uncertain significance Single submitter
- TXNL1 p.Arg259Lys Uncertain significance Single submitter
- TXNL1 p.Asn114Ser Uncertain significance Single submitter
- TXNL1 p.Asp116Val Uncertain significance Single submitter
- TXNL1 p.Asp147Glu Uncertain significance Single submitter
- TXNL1 p.Glu255Gly Uncertain significance Single submitter
- TXNL1 p.Gly35Glu Uncertain significance Single submitter
- TXNL1 p.Ile119Val Uncertain significance Single submitter
- TXNL1 p.Ile130Thr Uncertain significance Single submitter
- TXNL1 p.Ile196Thr Uncertain significance Single submitter
- TXNL1 p.Lys284Arg Uncertain significance Single submitter
- TXNL1 p.Pro111Ala Uncertain significance Single submitter
- TXNL1 p.Pro11Leu Uncertain significance Single submitter
- TXNL1 p.Pro11Thr Uncertain significance Single submitter
- TXNL1 p.Ser113Asn Uncertain significance Single submitter
- TXNL1 p.Ser141Asn Uncertain significance Single submitter
- TXNL1 p.Val281Ile Uncertain significance Single submitter
- TXNL1 p.Val7Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- TXNL1 p.Asn276Tyr Uncertain significance Single submitter
- TXNL1 p.Asp223His Uncertain significance Single submitter
- TXNL1 p.Glu213Lys Uncertain significance Single submitter
- TXNL1 p.Gly122Val Uncertain significance Single submitter
- TXNL1 p.His62Gln Uncertain significance Single submitter
- TXNL1 p.Met275Val Uncertain significance Single submitter
- TXNL1 p.Met31Val Uncertain significance Single submitter
All TXNL1 variants
Benign 2
- c.563-4A>G Multiple submitters
- p.Leu165= Single submitter
Likely benign 1
- p.Val61= Single submitter
Uncertain significance 25
- p.Ala25Thr Single submitter ⚠
- p.Arg259Lys Single submitter ⚠
- p.Asn114Ser Single submitter ⚠
- p.Asn276Tyr Single submitter ⚠
- p.Asp116Val Single submitter ⚠
- p.Asp147Glu Single submitter ⚠
- p.Asp223His Single submitter ⚠
- p.Glu213Lys Single submitter ⚠
- p.Glu255Gly Single submitter ⚠
- p.Gly122Val Single submitter ⚠
- p.Gly35Glu Single submitter ⚠
- p.His62Gln Single submitter ⚠
- p.Ile119Val Single submitter ⚠
- p.Ile130Thr Single submitter ⚠
- p.Ile196Thr Single submitter ⚠
- p.Lys284Arg Single submitter ⚠
- p.Met275Val Single submitter ⚠
- p.Met31Val Single submitter ⚠
- p.Pro111Ala Single submitter ⚠
- p.Pro11Leu Single submitter ⚠
- p.Pro11Thr Single submitter ⚠
- p.Ser113Asn Single submitter ⚠
- p.Ser141Asn Single submitter ⚠
- p.Val281Ile Single submitter ⚠
- p.Val7Ile Single submitter ⚠