TYRO3 — 98 ClinVar variants

All ClinVar germline TYRO3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 90 flagged for review →

6 Benign · 2 Likely benign · 90 Uncertain significance

Full TYRO3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 90

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 55

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 35

The independent predictors disagree with each other — read with care.

All TYRO3 variants

Benign 6

p.Ala815= Multiple submitters
p.Ala815Val Multiple submitters ⚠
p.Gly675Arg Multiple submitters
p.Pro183= Multiple submitters
p.Thr458= Multiple submitters
p.Val669Leu Multiple submitters

Likely benign 2

p.Asp415= Single submitter
p.Leu89Val Single submitter

Uncertain significance 90

p.Ser543Phe Multiple submitters hereditary breast ovarian cancer syndrome ⚠
p.Ala149Ser Single submitter ⚠
p.Ala149Val Single submitter ⚠
p.Ala325Thr Single submitter ⚠
p.Ala399Thr Single submitter ⚠
p.Ala444Thr Single submitter ⚠
p.Arg114Trp Single submitter ⚠
p.Arg393His Single submitter ⚠
p.Arg416Cys Single submitter ⚠
p.Arg426His Single submitter ⚠
p.Arg459Gln Single submitter ⚠
p.Arg459Pro Single submitter ⚠
p.Arg459Trp Single submitter ⚠
p.Arg478Trp Single submitter ⚠
p.Arg490His Single submitter ⚠
p.Arg522Gln Single submitter ⚠
p.Arg522Gly Single submitter ⚠
p.Arg619Trp Single submitter ⚠
p.Arg634Gln Single submitter ⚠
p.Arg649Pro Single submitter ⚠
p.Arg678Trp Single submitter ⚠
p.Arg687Cys Single submitter ⚠
p.Arg728Cys Single submitter ⚠
p.Arg809Lys Single submitter ⚠
p.Arg848Trp Single submitter ⚠
p.Asn366Ser Single submitter ⚠
p.Asn660Ile Single submitter ⚠
p.Asp502Asn Single submitter ⚠
p.Asp502Gly Single submitter ⚠
p.Asp510Val Single submitter ⚠
p.Asp801His Single submitter ⚠
p.Asp825Asn Single submitter ⚠
p.Cys64Ser Single submitter ⚠
p.Gln364His Single submitter ⚠
p.Glu352Lys Single submitter ⚠
p.Glu492Lys Single submitter ⚠
p.Glu702Lys Single submitter ⚠
p.Glu724Asp Single submitter ⚠
p.Glu740Val Single submitter ⚠
p.Glu756Asp Single submitter ⚠
p.Glu812Gln Single submitter ⚠
p.Glu820Gln Single submitter ⚠
p.Glu95Gly Single submitter ⚠
p.Gly421Val Single submitter ⚠
p.Gly68Arg Single submitter ⚠
p.Gly729Glu Single submitter ⚠
p.Gly838Ala Single submitter ⚠
p.Gly842Asp Single submitter ⚠
p.Gly854Arg Single submitter ⚠
p.Ile598Phe Single submitter ⚠
p.Leu512Phe Single submitter ⚠
p.Leu786Met Single submitter ⚠
p.Leu877Ile Single submitter ⚠
p.Lys318Met Single submitter ⚠
p.Lys582Asn Single submitter ⚠
p.Met200Ile Single submitter ⚠
p.Met468Leu Single submitter ⚠
p.Met523Ile Single submitter ⚠
p.Met636Val Single submitter ⚠
p.Pro151Leu Single submitter ⚠
p.Pro185Ala Single submitter ⚠
p.Pro266Ala Single submitter ⚠
p.Pro277Leu Single submitter ⚠
p.Pro314Leu Single submitter ⚠
p.Pro473Ser Single submitter ⚠
p.Pro49Arg Single submitter ⚠
p.Pro628Leu Single submitter ⚠
p.Pro755Leu Single submitter ⚠
p.Pro777Leu Single submitter ⚠
p.Ser103Arg Single submitter ⚠
p.Ser213Phe Single submitter ⚠
p.Ser242Arg Single submitter ⚠
p.Ser778Asn Single submitter ⚠
p.Ser794Pro Single submitter ⚠
p.Ser845Thr Single submitter ⚠
p.Ser869Cys Single submitter ⚠
p.Ser94Ile Single submitter ⚠
p.Thr134Met Single submitter ⚠
p.Thr814Ile Single submitter ⚠
p.Val119Leu Single submitter ⚠
p.Val260Ile Single submitter ⚠
p.Val392Ile Single submitter ⚠
p.Val430Ala Single submitter ⚠
p.Val430Gly Single submitter ⚠
p.Val436Met Single submitter ⚠
p.Val475Ile Single submitter ⚠
p.Val532Met Single submitter ⚠
p.Val696Ile Single submitter ⚠
p.Val77Leu Single submitter ⚠
p.Ala223fs No assertion criteria 46,XX disorder of sex development