UBXN4 — 68 ClinVar variants
All ClinVar germline UBXN4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
4 Likely benign · 64 Uncertain significance
Full UBXN4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 53
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- UBXN4 p.Ala303Thr Uncertain significance Single submitter
- UBXN4 p.Ala99Val Uncertain significance Single submitter
- UBXN4 p.Arg150Gly Uncertain significance Single submitter
- UBXN4 p.Arg198Gln Uncertain significance Single submitter
- UBXN4 p.Arg262Lys Uncertain significance Single submitter
- UBXN4 p.Arg282His Uncertain significance Single submitter
- UBXN4 p.Arg445Thr Uncertain significance Single submitter
- UBXN4 p.Asn51Lys Uncertain significance Single submitter
- UBXN4 p.Asp100Gly Uncertain significance Single submitter
- UBXN4 p.Asp275Asn Uncertain significance Single submitter
- UBXN4 p.Asp339Val Uncertain significance Single submitter
- UBXN4 p.Asp477Asn Uncertain significance Single submitter
- UBXN4 p.Asp491Asn Uncertain significance Single submitter
- UBXN4 p.Asp59Asn Uncertain significance Single submitter
- UBXN4 p.Asp59Glu Uncertain significance Single submitter
- UBXN4 p.Asp85Gly Uncertain significance Single submitter
- UBXN4 p.Gln148Lys Uncertain significance Single submitter
- UBXN4 p.Gln181Arg Uncertain significance Single submitter
- UBXN4 p.Gln335His Uncertain significance Single submitter
- UBXN4 p.Gln441Lys Uncertain significance Single submitter
- UBXN4 p.Glu315Gln Uncertain significance Single submitter
- UBXN4 p.Glu370Lys Uncertain significance Single submitter
- UBXN4 p.Glu384Gln Uncertain significance Single submitter
- UBXN4 p.Gly124Ser Uncertain significance Single submitter
- UBXN4 p.Gly475Arg Uncertain significance Single submitter
- UBXN4 p.His107Gln Uncertain significance Single submitter
- UBXN4 p.His405Tyr Uncertain significance Single submitter
- UBXN4 p.Ile403Val Uncertain significance Single submitter
- UBXN4 p.Leu154Phe Uncertain significance Single submitter
- UBXN4 p.Leu381Val Uncertain significance Single submitter
- UBXN4 p.Leu433Met Uncertain significance Single submitter
- UBXN4 p.Lys241Arg Uncertain significance Single submitter
- UBXN4 p.Lys285Arg Uncertain significance Single submitter
- UBXN4 p.Lys294Arg Uncertain significance Single submitter
- UBXN4 p.Lys459Arg Uncertain significance Single submitter
- UBXN4 p.Met365Val Uncertain significance Single submitter
- UBXN4 p.Met36Leu Uncertain significance Single submitter
- UBXN4 p.Phe432Ser Uncertain significance Single submitter
- UBXN4 p.Pro134Leu Uncertain significance Single submitter
- UBXN4 p.Pro159Ala Uncertain significance Single submitter
- UBXN4 p.Pro438Leu Uncertain significance Single submitter
- UBXN4 p.Pro451Thr Uncertain significance Single submitter
- UBXN4 p.Pro465Leu Uncertain significance Single submitter
- UBXN4 p.Ser130Leu Uncertain significance Single submitter
- UBXN4 p.Ser180Phe Uncertain significance Single submitter
- UBXN4 p.Ser456Pro Uncertain significance Single submitter
- UBXN4 p.Thr167Ala Uncertain significance Single submitter
- UBXN4 p.Thr34Arg Uncertain significance Single submitter
- UBXN4 p.Thr442Ser Uncertain significance Single submitter
- UBXN4 p.Val353Ile Uncertain significance Single submitter
- UBXN4 p.Val418Ala Uncertain significance Single submitter
- UBXN4 p.Val466Met Uncertain significance Single submitter
- UBXN4 p.Val470Leu Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- UBXN4 p.Ala292Asp Uncertain significance Single submitter
- UBXN4 p.Ala320Val Uncertain significance Single submitter
- UBXN4 p.Ala363Val Uncertain significance Single submitter
- UBXN4 p.Asp261Asn Uncertain significance Single submitter
- UBXN4 p.Glu260Asp Uncertain significance Single submitter
- UBXN4 p.Glu288Lys Uncertain significance Single submitter
- UBXN4 p.Lys285Met Uncertain significance Single submitter
- UBXN4 p.Ser390Leu Uncertain significance Single submitter
- UBXN4 p.Val199Met Uncertain significance Single submitter
All UBXN4 variants
Likely benign 4
- p.Arg110Gln Single submitter
- p.Asn141Asp Single submitter
- p.Asp43Glu Single submitter
- p.Glu101= Single submitter
Uncertain significance 64
- p.Ala292Asp Single submitter ⚠
- p.Ala303Thr Single submitter ⚠
- p.Ala320Gly Single submitter
- p.Ala320Val Single submitter ⚠
- p.Ala363Val Single submitter ⚠
- p.Ala99Val Single submitter ⚠
- p.Arg150Gly Single submitter ⚠
- p.Arg198Gln Single submitter ⚠
- p.Arg262Lys Single submitter ⚠
- p.Arg282His Single submitter ⚠
- p.Arg445Thr Single submitter ⚠
- p.Asn51Lys Single submitter ⚠
- p.Asp100Gly Single submitter ⚠
- p.Asp261Asn Single submitter ⚠
- p.Asp275Asn Single submitter ⚠
- p.Asp339Val Single submitter ⚠
- p.Asp477Asn Single submitter ⚠
- p.Asp491Asn Single submitter ⚠
- p.Asp59Asn Single submitter ⚠
- p.Asp59Glu Single submitter ⚠
- p.Asp85Gly Single submitter ⚠
- p.Gln148Lys Single submitter ⚠
- p.Gln181Arg Single submitter ⚠
- p.Gln335His Single submitter ⚠
- p.Gln441Lys Single submitter ⚠
- p.Glu260Asp Single submitter ⚠
- p.Glu288Lys Single submitter ⚠
- p.Glu315Gln Single submitter ⚠
- p.Glu370Lys Single submitter ⚠
- p.Glu384Gln Single submitter ⚠
- p.Gly124Ser Single submitter ⚠
- p.Gly475Arg Single submitter ⚠
- p.His107Gln Single submitter ⚠
- p.His405Tyr Single submitter ⚠
- p.Ile403Val Single submitter ⚠
- p.Leu154Phe Single submitter ⚠
- p.Leu381Val Single submitter ⚠
- p.Leu433Met Single submitter ⚠
- p.Lys241Arg Single submitter ⚠
- p.Lys285Arg Single submitter ⚠
- p.Lys285Met Single submitter ⚠
- p.Lys294Arg Single submitter ⚠
- p.Lys459Arg Single submitter ⚠
- p.Met365Val Single submitter ⚠
- p.Met36Leu Single submitter ⚠
- p.Phe432Ser Single submitter ⚠
- p.Pro134Leu Single submitter ⚠
- p.Pro159Ala Single submitter ⚠
- p.Pro438Leu Single submitter ⚠
- p.Pro451Thr Single submitter ⚠
- p.Pro465Leu Single submitter ⚠
- p.Ser130Leu Single submitter ⚠
- p.Ser180Phe Single submitter ⚠
- p.Ser388Gly Single submitter
- p.Ser390Leu Single submitter ⚠
- p.Ser456Pro Single submitter ⚠
- p.Thr167Ala Single submitter ⚠
- p.Thr34Arg Single submitter ⚠
- p.Thr442Ser Single submitter ⚠
- p.Val199Met Single submitter ⚠
- p.Val353Ile Single submitter ⚠
- p.Val418Ala Single submitter ⚠
- p.Val466Met Single submitter ⚠
- p.Val470Leu Single submitter ⚠