Sugi Variant

Sugi Variant/UNC45B

UNC45B — 398 ClinVar variants

All ClinVar germline UNC45B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 202 flagged for review →

3 Pathogenic · 3 Likely pathogenic · 6 Conflicting · 67 Benign · 9 Benign/Likely benign · 97 Likely benign · 213 Uncertain significance

Full UNC45B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 202

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 3

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 146

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 53

The independent predictors disagree with each other — read with care.

All UNC45B variants

Pathogenic 3

Likely pathogenic 3

Conflicting classifications of pathogenicity 6

Benign 67

Benign/Likely benign 9

Likely benign 97

Uncertain significance 213