URB2 — 232 ClinVar variants

All ClinVar germline URB2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 196 flagged for review →

3 Benign · 1 Benign/Likely benign · 24 Likely benign · 204 Uncertain significance

Full URB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 196

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 170

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 170

Predictors split 26

The independent predictors disagree with each other — read with care.

All URB2 variants

Benign 3

p.Arg1111His Multiple submitters
p.Met847Leu Multiple submitters
p.Pro992= Multiple submitters

Benign/Likely benign 1

p.Val1400Met Multiple submitters

Likely benign 24

p.Ala1028Thr Single submitter
p.Ala1082Glu Single submitter
p.Ala451Val Single submitter
p.Asp1138Asn Single submitter
p.Gly1338Ser Single submitter
p.Gly711Ser Single submitter
p.Ile375Val Single submitter
p.Ile416Met Single submitter
p.Ile864Val Single submitter
p.Ile93Val Single submitter
p.Leu1243Phe Single submitter
p.Leu511= Single submitter
p.Met1497Val Single submitter
p.Met989Val Single submitter
p.Pro1368Leu Single submitter
p.Pro588Leu Single submitter ⚠
p.Ser1085= Single submitter
p.Ser113Leu Single submitter
p.Thr1037Met Single submitter
p.Thr1122Met Single submitter
p.Thr1146Met Single submitter
p.Thr268Met Single submitter
p.Thr813Met Single submitter
p.Val1366Ile Single submitter

Uncertain significance 204

p.Ala1039Gly Single submitter ⚠
p.Ala1040Pro Single submitter ⚠
p.Ala1178Val Single submitter ⚠
p.Ala121Gly Single submitter ⚠
p.Ala1287Thr Single submitter ⚠
p.Ala1336Asp Single submitter ⚠
p.Ala134Thr Single submitter ⚠
p.Ala134Val Single submitter ⚠
p.Ala1437Thr Single submitter ⚠
p.Ala199Thr Single submitter ⚠
p.Ala29Pro Single submitter ⚠
p.Ala305Pro Single submitter ⚠
p.Ala305Val Single submitter ⚠
p.Ala368Asp Single submitter ⚠
p.Ala376Thr Single submitter
p.Ala448Thr Single submitter ⚠
p.Ala614Thr Single submitter ⚠
p.Ala810Thr Single submitter ⚠
p.Ala857Gly Single submitter ⚠
p.Arg1145Gly Single submitter ⚠
p.Arg124Gln Single submitter ⚠
p.Arg1292His Single submitter ⚠
p.Arg1292Pro Single submitter ⚠
p.Arg1306Leu Single submitter ⚠
p.Arg1331Gln Single submitter ⚠
p.Arg1331Trp Single submitter ⚠
p.Arg1369Gly Single submitter ⚠
p.Arg1408Trp Single submitter ⚠
p.Arg1426Cys Single submitter ⚠
p.Arg231Gln Single submitter ⚠
p.Arg330Met Single submitter ⚠
p.Arg381Gln Single submitter ⚠
p.Arg391Cys Single submitter ⚠
p.Arg391His Single submitter ⚠
p.Arg464Gln Single submitter ⚠
p.Arg479Cys Single submitter ⚠
p.Arg486Lys Single submitter ⚠
p.Arg567Gln Single submitter ⚠
p.Arg574Ser Single submitter ⚠
p.Arg829His Single submitter ⚠
p.Asn1372Lys Single submitter ⚠
p.Asn189His Single submitter
p.Asn370Lys Single submitter ⚠
p.Asn371Ser Single submitter ⚠
p.Asn399Tyr Single submitter ⚠
p.Asn716His Single submitter ⚠
p.Asp1222Val Single submitter ⚠
p.Asp1255Gly Single submitter ⚠
p.Asp1324Asn Single submitter ⚠
p.Asp196Asn Single submitter ⚠
p.Asp428Asn Single submitter ⚠
p.Asp532Glu Single submitter ⚠
p.Asp534Asn Single submitter ⚠
p.Asp757Gly Single submitter ⚠
p.Asp845Gly Single submitter ⚠
p.Asp969Gly Single submitter ⚠
p.Cys158Ser Single submitter ⚠
p.Gln1310Arg Single submitter ⚠
p.Gln1452Glu Single submitter ⚠
p.Gln1458Pro Single submitter ⚠
p.Gln168His Single submitter ⚠
p.Gln222Arg Single submitter ⚠
p.Gln321His Single submitter ⚠
p.Gln84Leu Single submitter ⚠
p.Gln905Lys Single submitter ⚠
p.Glu1079Ala Single submitter ⚠
p.Glu1125Lys Single submitter ⚠
p.Glu1285Lys Single submitter ⚠
p.Glu1483Lys Single submitter ⚠
p.Glu162Lys Single submitter ⚠
p.Glu256Gly Single submitter ⚠
p.Glu383Gln Single submitter ⚠
p.Glu439Asp Single submitter ⚠
p.Glu442Asp Single submitter ⚠
p.Glu472Asp Single submitter ⚠
p.Glu472Gln Single submitter ⚠
p.Glu61Gly Single submitter ⚠
p.Glu865Lys Single submitter ⚠
p.Gly1002Val Single submitter ⚠
p.Gly1156Arg Single submitter ⚠
p.Gly215Ser Single submitter ⚠
p.Gly223Ser Single submitter ⚠
p.Gly592Val Single submitter ⚠
p.Gly632Glu Single submitter ⚠
p.Gly650fs Single submitter epilepsy
p.His200Asp Single submitter ⚠
p.His547Tyr Single submitter ⚠
p.His797Arg Single submitter ⚠
p.His79Arg Single submitter ⚠
p.Ile103Met Single submitter ⚠
p.Ile1297Leu Single submitter ⚠
p.Ile1297Met Single submitter ⚠
p.Ile1297Thr Single submitter ⚠
p.Ile1415Val Single submitter ⚠
p.Ile237Phe Single submitter ⚠
p.Ile337Met Single submitter ⚠
p.Ile372Met Single submitter ⚠
p.Ile635Met Single submitter ⚠
p.Ile743Val Single submitter ⚠
p.Ile791Val Single submitter ⚠
p.Leu1030Phe Single submitter ⚠
p.Leu1087Val Single submitter ⚠
p.Leu1147Pro Single submitter ⚠
p.Leu1191Arg Single submitter ⚠
p.Leu123Phe Single submitter ⚠
p.Leu1274Pro Single submitter ⚠
p.Leu1330Pro Single submitter ⚠
p.Leu1355Val Single submitter ⚠
p.Leu526Phe Single submitter ⚠
p.Leu52Phe Single submitter
p.Leu639Met Single submitter ⚠
p.Leu644Phe Single submitter ⚠
p.Leu747Val Single submitter ⚠
p.Leu807Phe Single submitter ⚠
p.Leu83Trp Single submitter
p.Leu906Val Single submitter ⚠
p.Lys1016Met Single submitter ⚠
p.Lys1194Gln Single submitter ⚠
p.Lys1194Glu Single submitter ⚠
p.Lys1502Thr Single submitter ⚠
p.Lys15Asn Single submitter ⚠
p.Lys601Asn Single submitter ⚠
p.Lys652Arg Single submitter ⚠
p.Met1015Val Single submitter ⚠
p.Met1404Thr Single submitter ⚠
p.Met1431Thr Single submitter ⚠
p.Met240Ile Single submitter ⚠
p.Met240Thr Single submitter ⚠
p.Met271Val Single submitter ⚠
p.Met571Val Single submitter ⚠
p.Met576Ile Single submitter ⚠
p.Met619Thr Single submitter ⚠
p.Met619Val Single submitter ⚠
p.Met804Leu Single submitter ⚠
p.Met804Thr Single submitter ⚠
p.Met924Ile Single submitter ⚠
p.Phe110Leu Single submitter ⚠
p.Phe1396Ser Single submitter ⚠
p.Phe551Val Single submitter ⚠
p.Phe706Val Single submitter ⚠
p.Phe811Ser Single submitter ⚠
p.Phe856Tyr Single submitter ⚠
p.Phe941Ser Single submitter ⚠
p.Pro1105Leu Single submitter ⚠
p.Pro1213Ala Single submitter ⚠
p.Pro1321Leu Single submitter ⚠
p.Pro1340His Single submitter
p.Pro1354Ala Single submitter ⚠
p.Pro1360Leu Single submitter ⚠
p.Pro161His Single submitter ⚠
p.Pro190Arg Single submitter ⚠
p.Pro204Leu Single submitter
p.Pro480Leu Single submitter
p.Pro488Ser Single submitter ⚠
p.Pro563Ser Single submitter ⚠
p.Pro593Ser Single submitter ⚠
p.Pro595Arg Single submitter ⚠
p.Pro771Arg Single submitter ⚠
p.Pro771Ser Single submitter ⚠
p.Ser1114Leu Single submitter ⚠
p.Ser1121Thr Single submitter ⚠
p.Ser1492Leu Single submitter ⚠
p.Ser230Asn Single submitter ⚠
p.Ser433Ala Single submitter ⚠
p.Ser433Leu Single submitter ⚠
p.Ser646Leu Single submitter ⚠
p.Ser667Cys Single submitter ⚠
p.Ser80Arg Single submitter ⚠
p.Ser831Leu Single submitter ⚠
p.Thr1003Ala Single submitter ⚠
p.Thr1232Asn Single submitter ⚠
p.Thr1239Met Single submitter ⚠
p.Thr1272Ala Single submitter ⚠
p.Thr140Met Single submitter ⚠
p.Thr1420Met Single submitter ⚠
p.Thr1523Met Single submitter ⚠
p.Thr354Ile Single submitter ⚠
p.Thr671Ala Single submitter ⚠
p.Thr719Met Single submitter ⚠
p.Trp1260Arg Single submitter ⚠
p.Trp71Ser Single submitter ⚠
p.Tyr254Cys Single submitter
p.Tyr753Cys Single submitter ⚠
p.Tyr913Cys Single submitter ⚠
p.Val1020Met Single submitter ⚠
p.Val107Ala Single submitter ⚠
p.Val1091Ile Single submitter ⚠
p.Val1115Leu Single submitter ⚠
p.Val1198Met Single submitter ⚠
p.Val1318Ala Single submitter ⚠
p.Val1322Leu Single submitter ⚠
p.Val1444Ala Single submitter ⚠
p.Val1460Leu Single submitter ⚠
p.Val228Leu Single submitter ⚠
p.Val300Ala Single submitter ⚠
p.Val304Leu Single submitter ⚠
p.Val359Ile Single submitter ⚠
p.Val393Met Single submitter ⚠
p.Val476Leu Single submitter ⚠
p.Val525Gly Single submitter ⚠
p.Val580Met Single submitter ⚠
p.Val606Met Single submitter ⚠
p.Val926Phe Single submitter ⚠
p.Gln458Glu No assertion criteria prostate cancer ⚠