USP25 — 128 ClinVar variants

All ClinVar germline USP25 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 104 flagged for review →

2 Conflicting · 1 Benign · 9 Likely benign · 116 Uncertain significance

Full USP25 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 104

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

USP25 p.His1070Tyr Conflicting Single submitter

Predictors lean, ClinVar uncertain 79

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 24

The independent predictors disagree with each other — read with care.

All USP25 variants

Conflicting classifications of pathogenicity 2

p.His1070Tyr Single submitter ⚠
p.Val879Leu Single submitter ⚠

Benign 1

p.Lys1047Gln Single submitter

Likely benign 9

c.2727-5_2727-4dup Single submitter
p.Ala107= Single submitter
p.Ala1111= Single submitter
p.Ala718= Single submitter
p.Glu666= Single submitter
p.His599= Single submitter
p.Leu198= Single submitter
p.Phe1013= Single submitter
p.Tyr814fs Single submitter

Uncertain significance 116

p.Arg217Gln Multiple submitters ⚠
p.Val596Ile Multiple submitters ⚠
p.Ala474Thr Single submitter ⚠
p.Ala659Ser Single submitter ⚠
p.Ala705Val Single submitter ⚠
p.Ala718Val Single submitter ⚠
p.Ala919Thr Single submitter ⚠
p.Arg1058Gln Single submitter ⚠
p.Arg1112Gln Single submitter ⚠
p.Arg118Ser Single submitter ⚠
p.Arg153Gly Single submitter ⚠
p.Arg217Trp Single submitter ⚠
p.Arg223Cys Single submitter ⚠
p.Arg226Ser Single submitter ⚠
p.Arg413Ser Single submitter ⚠
p.Arg554Leu Single submitter ⚠
p.Arg746Gly Single submitter ⚠
p.Asn157Lys Single submitter ⚠
p.Asn328Ser Single submitter ⚠
p.Asn380Ser Single submitter
p.Asn561Asp Single submitter ⚠
p.Asn646Ser Single submitter ⚠
p.Asp871Asn Single submitter ⚠
p.Cys1085Tyr Single submitter ⚠
p.Cys910Tyr Single submitter
p.Gln18Arg Single submitter ⚠
p.Gln381Arg Single submitter ⚠
p.Gln485Leu Single submitter ⚠
p.Gln485Lys Single submitter ⚠
p.Gln494Arg Single submitter ⚠
p.Gln660Leu Single submitter ⚠
p.Gln664Arg Single submitter ⚠
p.Gln759Pro Single submitter ⚠
p.Gln898Glu Single submitter ⚠
p.Gln918Arg Single submitter ⚠
p.Glu1014Lys Single submitter
p.Glu1094Lys Single submitter ⚠
p.Glu150Ala Single submitter
p.Glu289Asp Single submitter ⚠
p.Glu378Val Single submitter ⚠
p.Glu434Gln Single submitter
p.Glu549Gly Single submitter ⚠
p.Glu558Lys Single submitter ⚠
p.Glu979Asp Single submitter ⚠
p.Gly1016Arg Single submitter
p.Gly442Cys Single submitter ⚠
p.Gly677Asp Single submitter ⚠
p.His16Arg Single submitter ⚠
p.His334Arg Single submitter ⚠
p.His350Arg Single submitter ⚠
p.His390Arg Single submitter ⚠
p.His519Arg Single submitter ⚠
p.His534Tyr Single submitter ⚠
p.His539Gln Single submitter
p.His607Gln Single submitter ⚠
p.His996Tyr Single submitter ⚠
p.Ile1049Val Single submitter ⚠
p.Ile35Val Single submitter ⚠
p.Ile411Leu Single submitter ⚠
p.Ile411Val Single submitter ⚠
p.Ile559Leu Single submitter ⚠
p.Ile559Thr Single submitter ⚠
p.Ile587Val Single submitter ⚠
p.Ile678Met Single submitter ⚠
p.Ile851Met Single submitter ⚠
p.Ile882Met Single submitter ⚠
p.Ile964Val Single submitter ⚠
p.Leu108Trp Single submitter ⚠
p.Leu198Arg Single submitter ⚠
p.Leu219Ser Single submitter ⚠
p.Leu970Val Single submitter
p.Leu980Val Single submitter
p.Lys1097Arg Single submitter ⚠
p.Lys145Arg Single submitter ⚠
p.Lys520Arg Single submitter ⚠
p.Lys630Arg Single submitter ⚠
p.Lys698Glu Single submitter ⚠
p.Lys978Asn Single submitter ⚠
p.Met1028Val Single submitter
p.Met1055Thr Single submitter ⚠
p.Met405Ile Single submitter ⚠
p.Met405Leu Single submitter ⚠
p.Phe20Leu Single submitter ⚠
p.Phe667Cys Single submitter ⚠
p.Phe749Leu Single submitter ⚠
p.Pro210Thr Single submitter ⚠
p.Pro220Ser Single submitter
p.Pro386Ser Single submitter ⚠
p.Pro443Thr Single submitter
p.Pro478Ser Single submitter ⚠
p.Pro683Leu Single submitter ⚠
p.Pro738Thr Single submitter ⚠
p.Pro773Leu Single submitter ⚠
p.Ser467Cys Single submitter ⚠
p.Ser513Leu Single submitter ⚠
p.Ser514Leu Single submitter ⚠
p.Ser525Cys Single submitter ⚠
p.Ser640Tyr Single submitter ⚠
p.Ser728Phe Single submitter ⚠
p.Thr1076Arg Single submitter ⚠
p.Thr1103Met Single submitter ⚠
p.Thr19Arg Single submitter ⚠
p.Thr412Ile Single submitter ⚠
p.Thr427Met Single submitter ⚠
p.Thr466Ile Single submitter ⚠
p.Thr866Ser Single submitter ⚠
p.Trp273Cys Single submitter ⚠
p.Trp609Cys Single submitter epilepsy, idiopathic generalized, susceptibility to, 19 ⚠
p.Trp609Leu Single submitter ⚠
p.Tyr439Cys Single submitter ⚠
p.Val169Ile Single submitter
p.Val233Ala Single submitter
p.Val547Ala Single submitter idiopathic generalized epilepsy ⚠
p.Val689Ala Single submitter ⚠
p.Val776Leu Single submitter ⚠
p.Val916Ile Single submitter ⚠