UTP18 — 92 ClinVar variants
All ClinVar germline UTP18 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 90 flagged for review →
2 Likely benign · 90 Uncertain significance
Full UTP18 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 90
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 70
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- UTP18 p.Ala244Gly Uncertain significance Single submitter
- UTP18 p.Ala33Val Uncertain significance Single submitter
- UTP18 p.Ala369Thr Uncertain significance Single submitter
- UTP18 p.Ala432Thr Uncertain significance Single submitter
- UTP18 p.Ala468Gly Uncertain significance Single submitter
- UTP18 p.Ala59Thr Uncertain significance Single submitter
- UTP18 p.Ala86Val Uncertain significance Single submitter
- UTP18 p.Arg161Gln Uncertain significance Single submitter
- UTP18 p.Arg161Pro Uncertain significance Single submitter
- UTP18 p.Arg202Gln Uncertain significance Single submitter
- UTP18 p.Arg253Gln Uncertain significance Single submitter
- UTP18 p.Arg384Lys Uncertain significance Single submitter
- UTP18 p.Arg75Trp Uncertain significance Single submitter
- UTP18 p.Arg77His Uncertain significance Single submitter
- UTP18 p.Asn101Lys Uncertain significance Single submitter
- UTP18 p.Asn240Ser Uncertain significance Single submitter
- UTP18 p.Asn285Asp Uncertain significance Single submitter
- UTP18 p.Asn285Lys Uncertain significance Single submitter
- UTP18 p.Asn306Ser Uncertain significance Single submitter
- UTP18 p.Asn482Ser Uncertain significance Single submitter
- UTP18 p.Asn512Asp Uncertain significance Single submitter
- UTP18 p.Asp102Asn Uncertain significance Single submitter
- UTP18 p.Asp102Gly Uncertain significance Single submitter
- UTP18 p.Asp163Gly Uncertain significance Single submitter
- UTP18 p.Asp213Gly Uncertain significance Single submitter
- UTP18 p.Asp281Gly Uncertain significance Single submitter
- UTP18 p.Asp410Glu Uncertain significance Single submitter
- UTP18 p.Asp455Val Uncertain significance Single submitter
- UTP18 p.Gln187His Uncertain significance Single submitter
- UTP18 p.Gln258Arg Uncertain significance Single submitter
- UTP18 p.Glu100Gln Uncertain significance Single submitter
- UTP18 p.Glu4Gly Uncertain significance Single submitter
- UTP18 p.Glu67Lys Uncertain significance Single submitter
- UTP18 p.Glu81Gln Uncertain significance Single submitter
- UTP18 p.Gly122Arg Uncertain significance Single submitter
- UTP18 p.Gly16Glu Uncertain significance Single submitter
- UTP18 p.His260Arg Uncertain significance Single submitter
- UTP18 p.His260Gln Uncertain significance Single submitter
- UTP18 p.His552Arg Uncertain significance Single submitter
- UTP18 p.His552Tyr Uncertain significance Single submitter
- UTP18 p.Ile451Val Uncertain significance Single submitter
- UTP18 p.Leu106Ser Uncertain significance Single submitter
- UTP18 p.Leu107Arg Uncertain significance Single submitter
- UTP18 p.Leu429Phe Uncertain significance Single submitter
- UTP18 p.Leu501Trp Uncertain significance Single submitter
- UTP18 p.Leu504Ile Uncertain significance Single submitter
- UTP18 p.Lys10Glu Uncertain significance Single submitter
- UTP18 p.Lys138Glu Uncertain significance Single submitter
- UTP18 p.Lys183Glu Uncertain significance Single submitter
- UTP18 p.Lys22Asn Uncertain significance Single submitter
- UTP18 p.Lys318Arg Uncertain significance Single submitter
- UTP18 p.Met156Val Uncertain significance Single submitter
- UTP18 p.Met527Thr Uncertain significance Single submitter
- UTP18 p.Phe513Ser Uncertain significance Single submitter
- UTP18 p.Pro136Ser Uncertain significance Single submitter
- UTP18 p.Pro19Arg Uncertain significance Single submitter
- UTP18 p.Pro297Leu Uncertain significance Single submitter
- UTP18 p.Pro35Ser Uncertain significance Single submitter
- UTP18 p.Pro50Arg Uncertain significance Single submitter
- UTP18 p.Pro54Gln Uncertain significance Single submitter
- UTP18 p.Ser230Thr Uncertain significance Single submitter
- UTP18 p.Ser46Phe Uncertain significance Single submitter
- UTP18 p.Ser530Phe Uncertain significance Single submitter
- UTP18 p.Ser533Gly Uncertain significance Single submitter
- UTP18 p.Thr15Ser Uncertain significance Single submitter
- UTP18 p.Thr250Ala Uncertain significance Single submitter
- UTP18 p.Tyr292Cys Uncertain significance Single submitter
- UTP18 p.Tyr323Cys Uncertain significance Single submitter
- UTP18 p.Tyr427Cys Uncertain significance Single submitter
- UTP18 p.Val336Ala Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- UTP18 p.Ala60Thr Uncertain significance Single submitter
- UTP18 p.Arg159Trp Uncertain significance Single submitter
- UTP18 p.Arg202Trp Uncertain significance Single submitter
- UTP18 p.Arg253Trp Uncertain significance Single submitter
- UTP18 p.Asn382Asp Uncertain significance Single submitter
- UTP18 p.Asp213Val Uncertain significance Single submitter
- UTP18 p.Gln258His Uncertain significance Single submitter
- UTP18 p.Ile376Phe Uncertain significance Single submitter
- UTP18 p.Leu182Phe Uncertain significance Single submitter
- UTP18 p.Leu91Trp Uncertain significance Single submitter
- UTP18 p.Lys373Ile Uncertain significance Single submitter
- UTP18 p.Met190Thr Uncertain significance Single submitter
- UTP18 p.Met267Ile Uncertain significance Single submitter
- UTP18 p.Pro463Leu Uncertain significance Single submitter
- UTP18 p.Pro505Leu Uncertain significance Single submitter
- UTP18 p.Ser304Asn Uncertain significance Single submitter
- UTP18 p.Ser346Ile Uncertain significance Single submitter
- UTP18 p.Ser401Leu Uncertain significance Single submitter
- UTP18 p.Val193Gly Uncertain significance Single submitter
- UTP18 p.Val411Ala Uncertain significance Single submitter
All UTP18 variants
Likely benign 2
- p.Gly32Arg Single submitter
- p.Val385Ile Single submitter
Uncertain significance 90
- p.Ala244Gly Single submitter ⚠
- p.Ala33Val Single submitter ⚠
- p.Ala369Thr Single submitter ⚠
- p.Ala432Thr Single submitter ⚠
- p.Ala468Gly Single submitter ⚠
- p.Ala59Thr Single submitter ⚠
- p.Ala60Thr Single submitter ⚠
- p.Ala86Val Single submitter ⚠
- p.Arg159Trp Single submitter ⚠
- p.Arg161Gln Single submitter ⚠
- p.Arg161Pro Single submitter ⚠
- p.Arg202Gln Single submitter ⚠
- p.Arg202Trp Single submitter ⚠
- p.Arg253Gln Single submitter ⚠
- p.Arg253Trp Single submitter ⚠
- p.Arg384Lys Single submitter ⚠
- p.Arg75Trp Single submitter ⚠
- p.Arg77His Single submitter ⚠
- p.Asn101Lys Single submitter ⚠
- p.Asn240Ser Single submitter ⚠
- p.Asn285Asp Single submitter ⚠
- p.Asn285Lys Single submitter ⚠
- p.Asn306Ser Single submitter ⚠
- p.Asn382Asp Single submitter ⚠
- p.Asn482Ser Single submitter ⚠
- p.Asn512Asp Single submitter ⚠
- p.Asp102Asn Single submitter ⚠
- p.Asp102Gly Single submitter ⚠
- p.Asp163Gly Single submitter ⚠
- p.Asp213Gly Single submitter ⚠
- p.Asp213Val Single submitter ⚠
- p.Asp281Gly Single submitter ⚠
- p.Asp410Glu Single submitter ⚠
- p.Asp455Val Single submitter ⚠
- p.Gln187His Single submitter ⚠
- p.Gln258Arg Single submitter ⚠
- p.Gln258His Single submitter ⚠
- p.Glu100Gln Single submitter ⚠
- p.Glu4Gly Single submitter ⚠
- p.Glu67Lys Single submitter ⚠
- p.Glu81Gln Single submitter ⚠
- p.Gly122Arg Single submitter ⚠
- p.Gly16Glu Single submitter ⚠
- p.His260Arg Single submitter ⚠
- p.His260Gln Single submitter ⚠
- p.His552Arg Single submitter ⚠
- p.His552Tyr Single submitter ⚠
- p.Ile376Phe Single submitter ⚠
- p.Ile451Val Single submitter ⚠
- p.Leu106Ser Single submitter ⚠
- p.Leu107Arg Single submitter ⚠
- p.Leu182Phe Single submitter ⚠
- p.Leu429Phe Single submitter ⚠
- p.Leu501Trp Single submitter ⚠
- p.Leu504Ile Single submitter ⚠
- p.Leu91Trp Single submitter ⚠
- p.Lys10Glu Single submitter ⚠
- p.Lys138Glu Single submitter ⚠
- p.Lys183Glu Single submitter ⚠
- p.Lys22Asn Single submitter ⚠
- p.Lys318Arg Single submitter ⚠
- p.Lys373Ile Single submitter ⚠
- p.Met156Val Single submitter ⚠
- p.Met190Thr Single submitter ⚠
- p.Met267Ile Single submitter ⚠
- p.Met527Thr Single submitter ⚠
- p.Phe513Ser Single submitter ⚠
- p.Pro136Ser Single submitter ⚠
- p.Pro19Arg Single submitter ⚠
- p.Pro297Leu Single submitter ⚠
- p.Pro35Ser Single submitter ⚠
- p.Pro463Leu Single submitter ⚠
- p.Pro505Leu Single submitter ⚠
- p.Pro50Arg Single submitter ⚠
- p.Pro54Gln Single submitter ⚠
- p.Ser230Thr Single submitter ⚠
- p.Ser304Asn Single submitter ⚠
- p.Ser346Ile Single submitter ⚠
- p.Ser401Leu Single submitter ⚠
- p.Ser46Phe Single submitter ⚠
- p.Ser530Phe Single submitter ⚠
- p.Ser533Gly Single submitter ⚠
- p.Thr15Ser Single submitter ⚠
- p.Thr250Ala Single submitter ⚠
- p.Tyr292Cys Single submitter ⚠
- p.Tyr323Cys Single submitter ⚠
- p.Tyr427Cys Single submitter ⚠
- p.Val193Gly Single submitter ⚠
- p.Val336Ala Single submitter ⚠
- p.Val411Ala Single submitter ⚠