VIPR1 — 91 ClinVar variants
All ClinVar germline VIPR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
8 Benign · 10 Likely benign · 73 Uncertain significance
Full VIPR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 57
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- VIPR1 p.Ala218Thr Uncertain significance Single submitter
- VIPR1 p.Ala276Ser Uncertain significance Single submitter
- VIPR1 p.Ala276Thr Uncertain significance Single submitter
- VIPR1 p.Ala276Val Uncertain significance Single submitter
- VIPR1 p.Ala30Val Uncertain significance Single submitter
- VIPR1 p.Ala54Asp Uncertain significance Single submitter
- VIPR1 p.Ala75Asp Uncertain significance Single submitter
- VIPR1 p.Arg103Cys Uncertain significance Single submitter
- VIPR1 p.Arg174Gln Uncertain significance Single submitter
- VIPR1 p.Arg252Gln Uncertain significance Single submitter
- VIPR1 p.Arg341Thr Uncertain significance Single submitter
- VIPR1 p.Arg439His Uncertain significance Single submitter
- VIPR1 p.Arg445Ser Uncertain significance Single submitter
- VIPR1 p.Arg78Gln Uncertain significance Single submitter
- VIPR1 p.Arg99His Uncertain significance Single submitter
- VIPR1 p.Asp126Asn Uncertain significance Single submitter
- VIPR1 p.Asp201Asn Uncertain significance Single submitter
- VIPR1 p.Asp282Asn Uncertain significance Single submitter
- VIPR1 p.Cys215Tyr Uncertain significance Single submitter
- VIPR1 p.Cys389Tyr Uncertain significance Single submitter
- VIPR1 p.Cys63Tyr Uncertain significance Single submitter
- VIPR1 p.Cys86Ser Uncertain significance Single submitter
- VIPR1 p.Gln46His Uncertain significance Single submitter
- VIPR1 p.Glu108Lys Uncertain significance Single submitter
- VIPR1 p.Glu114Lys Uncertain significance Single submitter
- VIPR1 p.Glu44Lys Uncertain significance Single submitter
- VIPR1 p.Gly140Arg Uncertain significance Single submitter
- VIPR1 p.Gly145Ser Uncertain significance Single submitter
- VIPR1 p.Gly203Arg Uncertain significance Single submitter
- VIPR1 p.Gly262Cys Uncertain significance Single submitter
- VIPR1 p.Gly284Arg Uncertain significance Single submitter
- VIPR1 p.Gly377Arg Uncertain significance Single submitter
- VIPR1 p.Ile120Thr Uncertain significance Single submitter
- VIPR1 p.Ile163Val Uncertain significance Single submitter
- VIPR1 p.Leu302Ile Uncertain significance Single submitter
- VIPR1 p.Leu70Phe Uncertain significance Single submitter
- VIPR1 p.Lys298Arg Uncertain significance Single submitter
- VIPR1 p.Met227Arg Uncertain significance Single submitter
- VIPR1 p.Met356Thr Uncertain significance Single submitter
- VIPR1 p.Met370Thr Uncertain significance Single submitter
- VIPR1 p.Pro117Leu Uncertain significance Single submitter
- VIPR1 p.Pro361Leu Uncertain significance Single submitter
- VIPR1 p.Pro87Arg Uncertain significance Single submitter
- VIPR1 p.Ser212Leu Uncertain significance Single submitter
- VIPR1 p.Ser333Asn Uncertain significance Single submitter
- VIPR1 p.Ser448Pro Uncertain significance Single submitter
- VIPR1 p.Thr136Ser Uncertain significance Single submitter
- VIPR1 p.Thr270Ser Uncertain significance Single submitter
- VIPR1 p.Thr274Ser Uncertain significance Single submitter
- VIPR1 p.Tyr241Cys Uncertain significance Single submitter
- VIPR1 p.Val142Met Uncertain significance Single submitter
- VIPR1 p.Val375Ile Uncertain significance Single submitter
- VIPR1 p.Val384Ala Uncertain significance Single submitter
- VIPR1 p.Val40Met Uncertain significance Single submitter
- VIPR1 p.Val411Ala Uncertain significance Single submitter
- VIPR1 p.Val411Phe Uncertain significance Single submitter
- VIPR1 p.Val434Ile Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- VIPR1 p.Ala191Thr Uncertain significance Single submitter
- VIPR1 p.Ala358Thr Uncertain significance Single submitter
- VIPR1 p.Ala397Glu Uncertain significance Single submitter
- VIPR1 p.Arg252Trp Uncertain significance Single submitter
- VIPR1 p.Glu281Lys Uncertain significance Single submitter
- VIPR1 p.Gly264Ala Uncertain significance Single submitter
- VIPR1 p.Gly79Ser Uncertain significance Single submitter
- VIPR1 p.Ile318Leu Uncertain significance Single submitter
- VIPR1 p.Ile89Thr Likely benign Single submitter
- VIPR1 p.Leu344Ile Uncertain significance Single submitter
- VIPR1 p.Leu374Phe Uncertain significance Single submitter
- VIPR1 p.Lys65Asn Uncertain significance Single submitter
- VIPR1 p.Pro115Leu Uncertain significance Single submitter
- VIPR1 p.Ser102Asn Uncertain significance Single submitter
- VIPR1 p.Ser212Trp Uncertain significance Single submitter
- VIPR1 p.Trp256Leu Uncertain significance Single submitter
All VIPR1 variants
Benign 8
- p.Ala129= Multiple submitters
- p.Arg445Leu Multiple submitters
- p.Asp126Gly Multiple submitters
- p.Glu398= Multiple submitters
- p.Pro361= Multiple submitters
- p.Ser205Leu Multiple submitters
- p.Thr111= Multiple submitters
- p.Val159= Multiple submitters
Likely benign 10
- c.400-9C>T Multiple submitters
- p.Tyr150= Multiple submitters
- c.1182+9C>T Single submitter
- p.Arg99Ser Single submitter
- p.Asp107Glu Single submitter
- p.Gln207Arg Single submitter
- p.Glu210Lys Single submitter
- p.Ile386Val Single submitter
- p.Ile89Thr Single submitter ⚠
- p.Ser455= Single submitter
Uncertain significance 73
- p.Ala191Thr Single submitter ⚠
- p.Ala218Thr Single submitter ⚠
- p.Ala276Ser Single submitter ⚠
- p.Ala276Thr Single submitter ⚠
- p.Ala276Val Single submitter ⚠
- p.Ala30Val Single submitter ⚠
- p.Ala358Thr Single submitter ⚠
- p.Ala397Glu Single submitter ⚠
- p.Ala54Asp Single submitter ⚠
- p.Ala75Asp Single submitter ⚠
- p.Arg103Cys Single submitter ⚠
- p.Arg174Gln Single submitter ⚠
- p.Arg252Gln Single submitter ⚠
- p.Arg252Trp Single submitter ⚠
- p.Arg341Thr Single submitter ⚠
- p.Arg439His Single submitter ⚠
- p.Arg445Ser Single submitter ⚠
- p.Arg78Gln Single submitter ⚠
- p.Arg99His Single submitter ⚠
- p.Asp126Asn Single submitter ⚠
- p.Asp201Asn Single submitter ⚠
- p.Asp282Asn Single submitter ⚠
- p.Cys215Tyr Single submitter ⚠
- p.Cys389Tyr Single submitter ⚠
- p.Cys63Tyr Single submitter ⚠
- p.Cys86Ser Single submitter ⚠
- p.Gln46His Single submitter ⚠
- p.Glu108Lys Single submitter ⚠
- p.Glu114Lys Single submitter ⚠
- p.Glu281Lys Single submitter ⚠
- p.Glu44Lys Single submitter ⚠
- p.Gly140Arg Single submitter ⚠
- p.Gly145Ser Single submitter ⚠
- p.Gly203Arg Single submitter ⚠
- p.Gly262Cys Single submitter ⚠
- p.Gly264Ala Single submitter ⚠
- p.Gly284Arg Single submitter ⚠
- p.Gly377Arg Single submitter ⚠
- p.Gly79Ser Single submitter ⚠
- p.Ile120Thr Single submitter ⚠
- p.Ile163Val Single submitter ⚠
- p.Ile318Leu Single submitter ⚠
- p.Leu302Ile Single submitter ⚠
- p.Leu344Ile Single submitter ⚠
- p.Leu374Phe Single submitter ⚠
- p.Leu70Phe Single submitter ⚠
- p.Lys298Arg Single submitter ⚠
- p.Lys65Asn Single submitter ⚠
- p.Met227Arg Single submitter ⚠
- p.Met356Thr Single submitter ⚠
- p.Met370Thr Single submitter ⚠
- p.Pro115Leu Single submitter ⚠
- p.Pro117Leu Single submitter ⚠
- p.Pro361Leu Single submitter ⚠
- p.Pro87Arg Single submitter ⚠
- p.Ser102Asn Single submitter ⚠
- p.Ser212Leu Single submitter ⚠
- p.Ser212Trp Single submitter ⚠
- p.Ser333Asn Single submitter ⚠
- p.Ser448Pro Single submitter ⚠
- p.Thr136Ser Single submitter ⚠
- p.Thr270Ser Single submitter ⚠
- p.Thr274Ser Single submitter ⚠
- p.Trp256Leu Single submitter ⚠
- p.Trp294Ser Single submitter
- p.Tyr241Cys Single submitter ⚠
- p.Val142Met Single submitter ⚠
- p.Val375Ile Single submitter ⚠
- p.Val384Ala Single submitter ⚠
- p.Val40Met Single submitter ⚠
- p.Val411Ala Single submitter ⚠
- p.Val411Phe Single submitter ⚠
- p.Val434Ile Single submitter ⚠