VPS26B — 21 ClinVar variants
All ClinVar germline VPS26B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
21 Uncertain significance
Full VPS26B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- VPS26B p.Ala94Ser Uncertain significance Single submitter
- VPS26B p.Arg269Cys Uncertain significance Single submitter
- VPS26B p.Arg269His Uncertain significance Single submitter
- VPS26B p.Arg294Gln Uncertain significance Single submitter
- VPS26B p.Arg324Trp Uncertain significance Single submitter
- VPS26B p.Arg80His Uncertain significance Single submitter
- VPS26B p.Gln8Pro Uncertain significance Single submitter
- VPS26B p.Ile200Met Uncertain significance Single submitter
- VPS26B p.Phe86Ser Uncertain significance Single submitter
- VPS26B p.Ser302Thr Uncertain significance Single submitter
- VPS26B p.Thr215Met Uncertain significance Single submitter
- VPS26B p.Val221Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- VPS26B p.Arg95Trp Uncertain significance Single submitter
- VPS26B p.Asp297Gly Uncertain significance Single submitter
- VPS26B p.Glu279Asp Uncertain significance Single submitter
- VPS26B p.Leu292Val Uncertain significance Single submitter
- VPS26B p.Phe129Leu Uncertain significance Single submitter
- VPS26B p.Phe38Ile Uncertain significance Single submitter
All VPS26B variants
Uncertain significance 21
- p.Ala94Ser Single submitter ⚠
- p.Arg269Cys Single submitter ⚠
- p.Arg269His Single submitter ⚠
- p.Arg294Gln Single submitter ⚠
- p.Arg324Trp Single submitter ⚠
- p.Arg80His Single submitter ⚠
- p.Arg95Trp Single submitter ⚠
- p.Asp297Gly Single submitter ⚠
- p.Gln8Pro Single submitter ⚠
- p.Glu279Asp Single submitter ⚠
- p.Glu315Lys Single submitter
- p.Glu35Gly Single submitter
- p.Ile14Met Single submitter
- p.Ile200Met Single submitter ⚠
- p.Leu292Val Single submitter ⚠
- p.Phe129Leu Single submitter ⚠
- p.Phe38Ile Single submitter ⚠
- p.Phe86Ser Single submitter ⚠
- p.Ser302Thr Single submitter ⚠
- p.Thr215Met Single submitter ⚠
- p.Val221Met Single submitter ⚠