WDR91 — 70 ClinVar variants
All ClinVar germline WDR91 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
1 Pathogenic · 2 Likely pathogenic · 2 Benign · 6 Likely benign · 59 Uncertain significance
Full WDR91 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- WDR91 p.Ala358Thr Uncertain significance Single submitter
- WDR91 p.Ala582Val Uncertain significance Single submitter
- WDR91 p.Arg258Cys Uncertain significance Single submitter
- WDR91 p.Arg258His Uncertain significance Single submitter
- WDR91 p.Arg329Gln Uncertain significance Single submitter
- WDR91 p.Arg329Trp Uncertain significance Single submitter
- WDR91 p.Arg332His Uncertain significance Single submitter
- WDR91 p.Arg379Trp Uncertain significance Single submitter
- WDR91 p.Arg391Leu Uncertain significance Single submitter
- WDR91 p.Arg462Gln Uncertain significance Single submitter
- WDR91 p.Arg711Gln Uncertain significance Single submitter
- WDR91 p.Asn233Ser Uncertain significance Single submitter
- WDR91 p.Asn438Ser Uncertain significance Single submitter
- WDR91 p.Asp335Tyr Uncertain significance Single submitter
- WDR91 p.Asp697Asn Uncertain significance Single submitter
- WDR91 p.Gln224His Uncertain significance Single submitter
- WDR91 p.Glu212Asp Uncertain significance Single submitter
- WDR91 p.Glu368Ala Uncertain significance Single submitter
- WDR91 p.Glu393Gln Uncertain significance Single submitter
- WDR91 p.Glu393Lys Uncertain significance Single submitter
- WDR91 p.Glu624Lys Uncertain significance Single submitter
- WDR91 p.Gly311Arg Uncertain significance Single submitter
- WDR91 p.Gly388Arg Uncertain significance Single submitter
- WDR91 p.Gly689Ser Uncertain significance Single submitter
- WDR91 p.His370Gln Uncertain significance Single submitter
- WDR91 p.Ile565Val Uncertain significance Single submitter
- WDR91 p.Leu242Ile Uncertain significance Single submitter
- WDR91 p.Leu314Phe Uncertain significance Single submitter
- WDR91 p.Leu343Val Uncertain significance Single submitter
- WDR91 p.Leu454Met Uncertain significance Single submitter
- WDR91 p.Leu707Arg Uncertain significance Single submitter
- WDR91 p.Lys300Arg Uncertain significance Single submitter
- WDR91 p.Lys341Arg Uncertain significance Single submitter
- WDR91 p.Pro452Leu Uncertain significance Single submitter
- WDR91 p.Pro560Leu Uncertain significance Single submitter
- WDR91 p.Ser240Leu Uncertain significance Single submitter
- WDR91 p.Ser313Ile Uncertain significance Single submitter
- WDR91 p.Ser419Cys Uncertain significance Single submitter
- WDR91 p.Ser647Leu Uncertain significance Single submitter
- WDR91 p.Tyr614Cys Uncertain significance Single submitter
- WDR91 p.Val188Ala Uncertain significance Single submitter
- WDR91 p.Val188Phe Uncertain significance Single submitter
- WDR91 p.Val428Ile Uncertain significance Single submitter
- WDR91 p.Val714Met Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- WDR91 p.Arg196Cys Uncertain significance Single submitter
- WDR91 p.Asp239Tyr Uncertain significance Single submitter
- WDR91 p.Asp625Gly Uncertain significance Single submitter
- WDR91 p.Asp718Asn Uncertain significance Single submitter
- WDR91 p.Gly238Arg Uncertain significance Single submitter
- WDR91 p.Gly623Ser Uncertain significance Single submitter
- WDR91 p.Lys450Asn Uncertain significance Single submitter
- WDR91 p.Ser240Trp Uncertain significance Single submitter
- WDR91 p.Val619Ala Uncertain significance Single submitter
All WDR91 variants
Pathogenic 1
- c.1768+1G>A Single submitter
Likely pathogenic 2
- c.511+1A>G Single submitter
- p.Gln334Ter Single submitter
Likely benign 6
- p.Gly324Ser Single submitter
- p.Gly695Ser Single submitter
- p.Phe294= Single submitter
- p.Thr305Met Single submitter
- p.Thr371Met Single submitter
- p.Val374Leu Single submitter
Uncertain significance 59
- p.Ala358Thr Single submitter ⚠
- p.Ala582Val Single submitter ⚠
- p.Ala673Val Single submitter
- p.Arg196Cys Single submitter ⚠
- p.Arg258Cys Single submitter ⚠
- p.Arg258His Single submitter ⚠
- p.Arg329Gln Single submitter ⚠
- p.Arg329Trp Single submitter ⚠
- p.Arg332His Single submitter ⚠
- p.Arg379Trp Single submitter ⚠
- p.Arg391Leu Single submitter ⚠
- p.Arg462Gln Single submitter ⚠
- p.Arg462Trp Single submitter
- p.Arg711Gln Single submitter ⚠
- p.Asn233Ser Single submitter ⚠
- p.Asn438Ser Single submitter ⚠
- p.Asp239Tyr Single submitter ⚠
- p.Asp335Tyr Single submitter ⚠
- p.Asp625Gly Single submitter ⚠
- p.Asp697Asn Single submitter ⚠
- p.Asp718Asn Single submitter ⚠
- p.Gln224His Single submitter ⚠
- p.Glu212Asp Single submitter ⚠
- p.Glu368Ala Single submitter ⚠
- p.Glu393Gln Single submitter ⚠
- p.Glu393Lys Single submitter ⚠
- p.Glu624Lys Single submitter ⚠
- p.Gly238Arg Single submitter ⚠
- p.Gly311Arg Single submitter ⚠
- p.Gly388Arg Single submitter ⚠
- p.Gly623Ser Single submitter ⚠
- p.Gly689Ser Single submitter ⚠
- p.His370Gln Single submitter ⚠
- p.Ile565Val Single submitter ⚠
- p.Leu209Pro Single submitter
- p.Leu242Ile Single submitter ⚠
- p.Leu314Phe Single submitter ⚠
- p.Leu343Val Single submitter ⚠
- p.Leu454Met Single submitter ⚠
- p.Leu707Arg Single submitter ⚠
- p.Lys300Arg Single submitter ⚠
- p.Lys341Arg Single submitter ⚠
- p.Lys450Asn Single submitter ⚠
- p.Pro376fs Single submitter
- p.Pro452Leu Single submitter ⚠
- p.Pro560Leu Single submitter ⚠
- p.Ser240Leu Single submitter ⚠
- p.Ser240Trp Single submitter ⚠
- p.Ser313Ile Single submitter ⚠
- p.Ser419Cys Single submitter ⚠
- p.Ser647Leu Single submitter ⚠
- p.Thr721Ile Single submitter
- p.Tyr230Ter Single submitter
- p.Tyr614Cys Single submitter ⚠
- p.Val188Ala Single submitter ⚠
- p.Val188Phe Single submitter ⚠
- p.Val428Ile Single submitter ⚠
- p.Val619Ala Single submitter ⚠
- p.Val714Met Single submitter ⚠