Sugi Variant

Sugi Variant/XDH

XDH — 1015 ClinVar variants

All ClinVar germline XDH variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 460 flagged for review →

19 Pathogenic · 3 Pathogenic/Likely pathogenic · 30 Likely pathogenic · 52 Conflicting · 111 Benign · 27 Benign/Likely benign · 247 Likely benign · 526 Uncertain significance

Full XDH gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 460

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 19

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 217

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 217

Predictors split 224

The independent predictors disagree with each other — read with care. · showing the 150 best-reviewed of 224

All XDH variants

Pathogenic 19

Pathogenic/Likely pathogenic 3

Likely pathogenic 30

Conflicting classifications of pathogenicity 52

Benign 111

Benign/Likely benign 27

Likely benign 247

Uncertain significance 526

Showing the top 300 by review status; the full set is in the sitemap.