XPO6 — 102 ClinVar variants

All ClinVar germline XPO6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 91 flagged for review →

1 Benign · 1 Likely benign · 100 Uncertain significance

Full XPO6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 91

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 63

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 28

The independent predictors disagree with each other — read with care.

All XPO6 variants

Benign 1

p.Arg887= Multiple submitters

Likely benign 1

p.Phe130= Single submitter

Uncertain significance 100

p.Ala249Gly Single submitter ⚠
p.Ala290Val Single submitter ⚠
p.Ala543Val Single submitter ⚠
p.Ala622Gly Single submitter
p.Ala6Gly Single submitter ⚠
p.Ala711Ser Single submitter ⚠
p.Ala916Thr Single submitter ⚠
p.Ala97Val Single submitter ⚠
p.Arg1019Trp Single submitter
p.Arg1086Gln Single submitter ⚠
p.Arg1086Trp Single submitter ⚠
p.Arg1092Trp Single submitter ⚠
p.Arg1109Cys Single submitter
p.Arg161His Single submitter ⚠
p.Arg29Cys Single submitter ⚠
p.Arg435His Single submitter ⚠
p.Arg445Gly Single submitter ⚠
p.Arg488Gln Single submitter ⚠
p.Arg566Cys Single submitter ⚠
p.Arg644Gln Single submitter ⚠
p.Arg724Gln Single submitter
p.Arg763Cys Single submitter ⚠
p.Arg847Gln Single submitter ⚠
p.Arg887Gln Single submitter ⚠
p.Asn352Ser Single submitter ⚠
p.Asn704Ser Single submitter ⚠
p.Asn73Ser Single submitter ⚠
p.Asp1057Asn Single submitter ⚠
p.Asp196Asn Single submitter ⚠
p.Asp58Glu Single submitter ⚠
p.Asp761Tyr Single submitter ⚠
p.Asp992Asn Single submitter ⚠
p.Cys1073Tyr Single submitter
p.Gln120Arg Single submitter ⚠
p.Gln181His Single submitter ⚠
p.Gln562Arg Single submitter ⚠
p.Gln645Arg Single submitter ⚠
p.Gln831Lys Single submitter ⚠
p.Gln901Arg Single submitter ⚠
p.Glu33Gly Single submitter ⚠
p.Glu387Lys Single submitter ⚠
p.Glu396Gly Single submitter ⚠
p.Glu447Lys Single submitter ⚠
p.Glu937Lys Single submitter ⚠
p.Gly185Ala Single submitter ⚠
p.Gly189Asp Single submitter ⚠
p.Gly306Cys Single submitter ⚠
p.His127Gln Single submitter
p.His786Tyr Single submitter ⚠
p.Ile1017Val Single submitter ⚠
p.Ile117Val Single submitter ⚠
p.Ile235Phe Single submitter ⚠
p.Ile368Val Single submitter ⚠
p.Ile980Met Single submitter ⚠
p.Ile993Val Single submitter ⚠
p.Leu134Phe Single submitter ⚠
p.Leu470Arg Single submitter ⚠
p.Leu512Met Single submitter ⚠
p.Lys439Met Single submitter ⚠
p.Met313Val Single submitter ⚠
p.Met327Thr Single submitter ⚠
p.Met327Val Single submitter ⚠
p.Met336Val Single submitter ⚠
p.Met75Thr Single submitter ⚠
p.Phe397Leu Single submitter ⚠
p.Phe463Cys Single submitter ⚠
p.Phe841Val Single submitter ⚠
p.Pro1119Ser Single submitter ⚠
p.Pro144Arg Single submitter ⚠
p.Pro144His Single submitter ⚠
p.Pro206Ser Single submitter ⚠
p.Pro209Leu Single submitter ⚠
p.Pro268Ala Single submitter
p.Pro697Ser Single submitter ⚠
p.Pro745Ser Single submitter ⚠
p.Pro903Ala Single submitter ⚠
p.Pro92Ser Single submitter ⚠
p.Ser208Tyr Single submitter ⚠
p.Ser214Cys Single submitter ⚠
p.Ser242Asn Single submitter ⚠
p.Ser258Gly Single submitter ⚠
p.Ser430Asn Single submitter ⚠
p.Thr182Ala Single submitter ⚠
p.Thr273Ala Single submitter ⚠
p.Thr410Ile Single submitter ⚠
p.Thr422Met Single submitter ⚠
p.Thr542Met Single submitter ⚠
p.Thr647Met Single submitter ⚠
p.Thr945Met Single submitter ⚠
p.Tyr342His Single submitter ⚠
p.Val1029Leu Single submitter ⚠
p.Val1029Met Single submitter ⚠
p.Val310Leu Single submitter ⚠
p.Val531Leu Single submitter ⚠
p.Val564Gly Single submitter
p.Val564Met Single submitter ⚠
p.Val669Ala Single submitter
p.Val682Leu Single submitter ⚠
p.Val791Ile Single submitter ⚠
p.Val820Gly Single submitter ⚠