XPOT — 79 ClinVar variants
All ClinVar germline XPOT variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 75 flagged for review →
79 Uncertain significance
Full XPOT gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 75
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 68
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- XPOT p.Ala425Thr Uncertain significance Multiple submitters
- XPOT p.Ala318Ser Uncertain significance Single submitter
- XPOT p.Ala41Gly Uncertain significance Single submitter
- XPOT p.Ala425Gly Uncertain significance Single submitter
- XPOT p.Ala477Gly Uncertain significance Single submitter
- XPOT p.Ala615Asp Uncertain significance Single submitter
- XPOT p.Ala771Gly Uncertain significance Single submitter
- XPOT p.Ala788Thr Uncertain significance Single submitter
- XPOT p.Ala819Ser Uncertain significance Single submitter
- XPOT p.Ala960Thr Uncertain significance Single submitter
- XPOT p.Arg144Gln Uncertain significance Single submitter
- XPOT p.Arg156Cys Uncertain significance Single submitter
- XPOT p.Arg166His Uncertain significance Single submitter
- XPOT p.Arg428Gly Uncertain significance Single submitter
- XPOT p.Arg428His Uncertain significance Single submitter
- XPOT p.Arg45Gly Uncertain significance Single submitter
- XPOT p.Arg534Gln Uncertain significance Single submitter
- XPOT p.Arg778Gln Uncertain significance Single submitter
- XPOT p.Asn228His Uncertain significance Single submitter
- XPOT p.Asn560Tyr Uncertain significance Single submitter
- XPOT p.Asp640Gly Uncertain significance Single submitter
- XPOT p.Asp649Asn Uncertain significance Single submitter
- XPOT p.Asp698Gly Uncertain significance Single submitter
- XPOT p.Gln272Leu Uncertain significance Single submitter
- XPOT p.Gln367His Uncertain significance Single submitter
- XPOT p.Gln439Arg Uncertain significance Single submitter
- XPOT p.Gln639Glu Uncertain significance Single submitter
- XPOT p.Glu242Ala Uncertain significance Single submitter
- XPOT p.Glu504Lys Uncertain significance Single submitter
- XPOT p.Glu575Ala Uncertain significance Single submitter
- XPOT p.Glu580Gln Uncertain significance Single submitter
- XPOT p.Glu678Lys Uncertain significance Single submitter
- XPOT p.Glu81Gly Uncertain significance Single submitter
- XPOT p.Glu835Asp Uncertain significance Single submitter
- XPOT p.Glu835Gln Uncertain significance Single submitter
- XPOT p.Gly313Glu Uncertain significance Single submitter
- XPOT p.His356Tyr Uncertain significance Single submitter
- XPOT p.His530Tyr Uncertain significance Single submitter
- XPOT p.His770Leu Uncertain significance Single submitter
- XPOT p.Ile149Val Uncertain significance Single submitter
- XPOT p.Ile279Thr Uncertain significance Single submitter
- XPOT p.Ile570Leu Uncertain significance Single submitter
- XPOT p.Ile755Met Uncertain significance Single submitter
- XPOT p.Ile873Val Uncertain significance Single submitter
- XPOT p.Leu170Val Uncertain significance Single submitter
- XPOT p.Leu632Val Uncertain significance Single submitter
- XPOT p.Leu700Ile Uncertain significance Single submitter
- XPOT p.Leu855Pro Uncertain significance Single submitter
- XPOT p.Leu92Pro Uncertain significance Single submitter
- XPOT p.Met175Leu Uncertain significance Single submitter
- XPOT p.Met229Val Uncertain significance Single submitter
- XPOT p.Met625Thr Uncertain significance Single submitter
- XPOT p.Met766Val Uncertain significance Single submitter
- XPOT p.Pro136Leu Uncertain significance Single submitter
- XPOT p.Pro521Ser Uncertain significance Single submitter
- XPOT p.Pro767Ala Uncertain significance Single submitter
- XPOT p.Ser307Asn Uncertain significance Single submitter
- XPOT p.Ser476Asn Uncertain significance Single submitter
- XPOT p.Ser497Cys Uncertain significance Single submitter
- XPOT p.Thr544Ser Uncertain significance Single submitter
- XPOT p.Thr706Ala Uncertain significance Single submitter
- XPOT p.Thr82Ala Uncertain significance Single submitter
- XPOT p.Val285Gly Uncertain significance Single submitter
- XPOT p.Val430Ile Uncertain significance Single submitter
- XPOT p.Val523Ile Uncertain significance Single submitter
- XPOT p.Val604Ile Uncertain significance Single submitter
- XPOT p.Val863Met Uncertain significance Single submitter
- XPOT p.Val869Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- XPOT p.Arg795Trp Uncertain significance Single submitter
- XPOT p.Asp155Glu Uncertain significance Single submitter
- XPOT p.Glu164Ala Uncertain significance Single submitter
- XPOT p.Lys308Glu Uncertain significance Single submitter
- XPOT p.Ser219Phe Uncertain significance Single submitter
- XPOT p.Thr161Ile Uncertain significance Single submitter
- XPOT p.Val285Phe Uncertain significance Single submitter
All XPOT variants
Uncertain significance 79
- p.Ala425Thr Multiple submitters ⚠
- p.Ala318Ser Single submitter ⚠
- p.Ala41Gly Single submitter ⚠
- p.Ala425Gly Single submitter ⚠
- p.Ala477Gly Single submitter ⚠
- p.Ala615Asp Single submitter ⚠
- p.Ala771Gly Single submitter ⚠
- p.Ala788Thr Single submitter ⚠
- p.Ala819Ser Single submitter ⚠
- p.Ala960Thr Single submitter ⚠
- p.Arg144Gln Single submitter ⚠
- p.Arg156Cys Single submitter ⚠
- p.Arg166His Single submitter ⚠
- p.Arg428Gly Single submitter ⚠
- p.Arg428His Single submitter ⚠
- p.Arg45Gly Single submitter ⚠
- p.Arg534Gln Single submitter ⚠
- p.Arg778Gln Single submitter ⚠
- p.Arg795Trp Single submitter ⚠
- p.Asn228His Single submitter ⚠
- p.Asn560Tyr Single submitter ⚠
- p.Asp14His Single submitter
- p.Asp155Glu Single submitter ⚠
- p.Asp640Gly Single submitter ⚠
- p.Asp649Asn Single submitter ⚠
- p.Asp698Gly Single submitter ⚠
- p.Gln272Leu Single submitter ⚠
- p.Gln367His Single submitter ⚠
- p.Gln439Arg Single submitter ⚠
- p.Gln639Glu Single submitter ⚠
- p.Gln803_Thr804insTer Single submitter
- p.Glu164Ala Single submitter ⚠
- p.Glu242Ala Single submitter ⚠
- p.Glu504Lys Single submitter ⚠
- p.Glu575Ala Single submitter ⚠
- p.Glu580Gln Single submitter ⚠
- p.Glu678Lys Single submitter ⚠
- p.Glu81Gly Single submitter ⚠
- p.Glu835Asp Single submitter ⚠
- p.Glu835Gln Single submitter ⚠
- p.Gly313Glu Single submitter ⚠
- p.Gly864Arg Single submitter
- p.His356Tyr Single submitter ⚠
- p.His530Tyr Single submitter ⚠
- p.His770Leu Single submitter ⚠
- p.Ile149Val Single submitter ⚠
- p.Ile279Thr Single submitter ⚠
- p.Ile570Leu Single submitter ⚠
- p.Ile755Met Single submitter ⚠
- p.Ile873Val Single submitter ⚠
- p.Leu170Val Single submitter ⚠
- p.Leu632Val Single submitter ⚠
- p.Leu700Ile Single submitter ⚠
- p.Leu855Pro Single submitter ⚠
- p.Leu92Pro Single submitter ⚠
- p.Lys308Glu Single submitter ⚠
- p.Met175Leu Single submitter ⚠
- p.Met229Val Single submitter ⚠
- p.Met625Thr Single submitter ⚠
- p.Met766Val Single submitter ⚠
- p.Pro136Leu Single submitter ⚠
- p.Pro521Ser Single submitter ⚠
- p.Pro767Ala Single submitter ⚠
- p.Ser219Phe Single submitter ⚠
- p.Ser307Asn Single submitter ⚠
- p.Ser476Asn Single submitter ⚠
- p.Ser497Cys Single submitter ⚠
- p.Thr161Ile Single submitter ⚠
- p.Thr544Ser Single submitter ⚠
- p.Thr706Ala Single submitter ⚠
- p.Thr82Ala Single submitter ⚠
- p.Val285Gly Single submitter ⚠
- p.Val285Phe Single submitter ⚠
- p.Val329Met Single submitter
- p.Val430Ile Single submitter ⚠
- p.Val523Ile Single submitter ⚠
- p.Val604Ile Single submitter ⚠
- p.Val863Met Single submitter ⚠
- p.Val869Ile Single submitter ⚠