YTHDC1 — 63 ClinVar variants
All ClinVar germline YTHDC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
2 Likely benign · 61 Uncertain significance
Full YTHDC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- YTHDC1 p.Arg113Gln Uncertain significance Single submitter
- YTHDC1 p.Arg136Gln Uncertain significance Single submitter
- YTHDC1 p.Arg341Gln Uncertain significance Single submitter
- YTHDC1 p.Arg522His Uncertain significance Single submitter
- YTHDC1 p.Arg59Gln Uncertain significance Single submitter
- YTHDC1 p.Asp139Glu Uncertain significance Single submitter
- YTHDC1 p.Asp208Glu Uncertain significance Single submitter
- YTHDC1 p.Asp253Asn Uncertain significance Single submitter
- YTHDC1 p.Asp56Tyr Uncertain significance Single submitter
- YTHDC1 p.Asp688Asn Uncertain significance Single submitter
- YTHDC1 p.Gln194His Uncertain significance Single submitter
- YTHDC1 p.Glu173Asp Uncertain significance Single submitter
- YTHDC1 p.Glu223Gly Uncertain significance Single submitter
- YTHDC1 p.Glu249Ala Uncertain significance Single submitter
- YTHDC1 p.Glu698Gly Uncertain significance Single submitter
- YTHDC1 p.Gly156Arg Uncertain significance Single submitter
- YTHDC1 p.Gly189Asp Uncertain significance Single submitter
- YTHDC1 p.Leu69Pro Uncertain significance Single submitter
- YTHDC1 p.Lys328Arg Uncertain significance Single submitter
- YTHDC1 p.Lys42Gln Uncertain significance Single submitter
- YTHDC1 p.Lys444Gln Uncertain significance Single submitter
- YTHDC1 p.Lys9Glu Uncertain significance Single submitter
- YTHDC1 p.Met52Ile Uncertain significance Single submitter
- YTHDC1 p.Pro130Leu Uncertain significance Single submitter
- YTHDC1 p.Pro603Ser Uncertain significance Single submitter
- YTHDC1 p.Pro610Ser Uncertain significance Single submitter
- YTHDC1 p.Ser164Asn Uncertain significance Single submitter
- YTHDC1 p.Ser334Leu Uncertain significance Single submitter
- YTHDC1 p.Ser346Asn Uncertain significance Single submitter
- YTHDC1 p.Ser71Pro Uncertain significance Single submitter
- YTHDC1 p.Ser86Asn Uncertain significance Single submitter
- YTHDC1 p.Ser86Gly Uncertain significance Single submitter
- YTHDC1 p.Thr185Ser Uncertain significance Single submitter
- YTHDC1 p.Thr198Ala Uncertain significance Single submitter
- YTHDC1 p.Thr55Ser Uncertain significance Single submitter
- YTHDC1 p.Tyr100Ser Uncertain significance Single submitter
- YTHDC1 p.Tyr126Cys Uncertain significance Single submitter
- YTHDC1 p.Tyr553Cys Uncertain significance Single submitter
- YTHDC1 p.Tyr569Cys Uncertain significance Single submitter
- YTHDC1 p.Tyr725Phe Uncertain significance Single submitter
- YTHDC1 p.Val278Leu Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- YTHDC1 p.Arg301Ser Uncertain significance Single submitter
- YTHDC1 p.Arg526Gly Uncertain significance Single submitter
- YTHDC1 p.Arg535Cys Uncertain significance Single submitter
- YTHDC1 p.Arg560Gly Uncertain significance Single submitter
- YTHDC1 p.Arg674Gln Uncertain significance Single submitter
- YTHDC1 p.Arg675Ser Uncertain significance Single submitter
- YTHDC1 p.Arg679Cys Uncertain significance Single submitter
- YTHDC1 p.Arg699Gln Uncertain significance Single submitter
- YTHDC1 p.Arg717Gly Uncertain significance Single submitter
- YTHDC1 p.Arg719Gln Uncertain significance Single submitter
- YTHDC1 p.Asp704Gly Uncertain significance Single submitter
- YTHDC1 p.Glu12Ala Uncertain significance Single submitter
- YTHDC1 p.Glu231Asp Uncertain significance Single submitter
- YTHDC1 p.Glu241Gln Uncertain significance Single submitter
- YTHDC1 p.Gly600Glu Uncertain significance Single submitter
- YTHDC1 p.Lys302Glu Uncertain significance Single submitter
- YTHDC1 p.Lys46Glu Uncertain significance Single submitter
- YTHDC1 p.Tyr563His Uncertain significance Single submitter
All YTHDC1 variants
Likely benign 2
- p.Gly274Asp Single submitter
- p.Glu249del No assertion criteria YTHDC1-related disorder
Uncertain significance 61
- c.1349+1dup Single submitter
- p.Arg113Gln Single submitter ⚠
- p.Arg136Gln Single submitter ⚠
- p.Arg301Ser Single submitter ⚠
- p.Arg341Gln Single submitter ⚠
- p.Arg522His Single submitter ⚠
- p.Arg526Gly Single submitter ⚠
- p.Arg535Cys Single submitter ⚠
- p.Arg560Gly Single submitter ⚠
- p.Arg59Gln Single submitter ⚠
- p.Arg674Gln Single submitter ⚠
- p.Arg675Ser Single submitter ⚠
- p.Arg679Cys Single submitter ⚠
- p.Arg699Gln Single submitter ⚠
- p.Arg717Gly Single submitter ⚠
- p.Arg719Gln Single submitter ⚠
- p.Asp139Glu Single submitter ⚠
- p.Asp208Glu Single submitter ⚠
- p.Asp253Asn Single submitter ⚠
- p.Asp56Tyr Single submitter ⚠
- p.Asp688Asn Single submitter ⚠
- p.Asp704Gly Single submitter ⚠
- p.Gln194His Single submitter ⚠
- p.Glu12Ala Single submitter ⚠
- p.Glu173Asp Single submitter ⚠
- p.Glu223Gly Single submitter ⚠
- p.Glu231Asp Single submitter ⚠
- p.Glu241Gln Single submitter ⚠
- p.Glu249Ala Single submitter ⚠
- p.Glu698Gly Single submitter ⚠
- p.Gly156Arg Single submitter ⚠
- p.Gly189Asp Single submitter ⚠
- p.Gly600Glu Single submitter ⚠
- p.Leu69Pro Single submitter ⚠
- p.Lys302Glu Single submitter ⚠
- p.Lys328Arg Single submitter ⚠
- p.Lys42Gln Single submitter ⚠
- p.Lys444Gln Single submitter ⚠
- p.Lys46Glu Single submitter ⚠
- p.Lys9Glu Single submitter ⚠
- p.Met52Ile Single submitter ⚠
- p.Pro130Leu Single submitter ⚠
- p.Pro603Ser Single submitter ⚠
- p.Pro604Leu Single submitter
- p.Pro610Ser Single submitter ⚠
- p.Ser164Asn Single submitter ⚠
- p.Ser334Leu Single submitter ⚠
- p.Ser346Asn Single submitter ⚠
- p.Ser71Pro Single submitter ⚠
- p.Ser86Asn Single submitter ⚠
- p.Ser86Gly Single submitter ⚠
- p.Thr185Ser Single submitter ⚠
- p.Thr198Ala Single submitter ⚠
- p.Thr55Ser Single submitter ⚠
- p.Tyr100Ser Single submitter ⚠
- p.Tyr126Cys Single submitter ⚠
- p.Tyr553Cys Single submitter ⚠
- p.Tyr563His Single submitter ⚠
- p.Tyr569Cys Single submitter ⚠
- p.Tyr725Phe Single submitter ⚠
- p.Val278Leu Single submitter ⚠