ZC3H18 — 157 ClinVar variants

All ClinVar germline ZC3H18 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 146 flagged for review →

1 Benign · 10 Likely benign · 146 Uncertain significance

Full ZC3H18 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 146

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 111

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 35

The independent predictors disagree with each other — read with care.

All ZC3H18 variants

Benign 1

p.Ser34= Multiple submitters

Likely benign 10

p.Arg415= Single submitter
p.Arg753Lys Single submitter
p.Asp35Glu Single submitter
p.His66Tyr Single submitter
p.Pro58Leu Single submitter
p.Pro608= Single submitter
p.Pro642Leu Single submitter
p.Thr504Ser Single submitter
p.Thr683= Single submitter
p.Val637Leu Single submitter

Uncertain significance 146

p.Ala150Val Single submitter ⚠
p.Ala182Thr Single submitter ⚠
p.Ala276Thr Single submitter ⚠
p.Ala276Val Single submitter ⚠
p.Ala54Thr Single submitter ⚠
p.Ala551Pro Single submitter ⚠
p.Ala551Val Single submitter ⚠
p.Ala55Val Single submitter ⚠
p.Ala632Val Single submitter ⚠
p.Ala668Thr Single submitter ⚠
p.Ala723Thr Single submitter ⚠
p.Ala742Pro Single submitter ⚠
p.Ala782Thr Single submitter ⚠
p.Ala915Thr Single submitter ⚠
p.Arg30Thr Single submitter ⚠
p.Arg318Gln Single submitter ⚠
p.Arg339Gln Single submitter ⚠
p.Arg339Trp Single submitter ⚠
p.Arg455His Single submitter ⚠
p.Arg455Pro Single submitter ⚠
p.Arg457Gln Single submitter ⚠
p.Arg472Gln Single submitter ⚠
p.Arg472Trp Single submitter ⚠
p.Arg493Cys Single submitter ⚠
p.Arg493His Single submitter ⚠
p.Arg537Gln Single submitter ⚠
p.Arg541His Single submitter ⚠
p.Arg542Gln Single submitter ⚠
p.Arg575Gly Single submitter ⚠
p.Arg575Pro Single submitter ⚠
p.Arg596Trp Single submitter ⚠
p.Arg666Gln Single submitter ⚠
p.Arg666Trp Single submitter ⚠
p.Arg673Trp Single submitter ⚠
p.Arg72Gly Single submitter ⚠
p.Arg72Trp Single submitter ⚠
p.Arg753Met Single submitter ⚠
p.Arg770Gln Single submitter ⚠
p.Arg840Trp Single submitter ⚠
p.Arg855Leu Single submitter ⚠
p.Arg858Trp Single submitter ⚠
p.Arg860Gln Single submitter ⚠
p.Arg873Gln Single submitter ⚠
p.Arg90Gln Single submitter ⚠
p.Asn231Tyr Single submitter ⚠
p.Asn553Asp Single submitter ⚠
p.Asp111Asn Single submitter ⚠
p.Asp154Glu Single submitter ⚠
p.Asp191Asn Single submitter ⚠
p.Asp26Asn Single submitter ⚠
p.Asp35Asn Single submitter ⚠
p.Asp361Asn Single submitter ⚠
p.Asp461Asn Single submitter ⚠
p.Asp461Glu Single submitter ⚠
p.Asp47Glu Single submitter ⚠
p.Asp50Asn Single submitter ⚠
p.Asp71Ala Single submitter ⚠
p.Asp730His Single submitter ⚠
p.Asp837Glu Single submitter ⚠
p.Gln798Arg Single submitter ⚠
p.Gln798Glu Single submitter ⚠
p.Glu15Lys Single submitter ⚠
p.Glu165Val Single submitter ⚠
p.Glu338Asp Single submitter ⚠
p.Glu394Gly Single submitter ⚠
p.Glu439Ala Single submitter ⚠
p.Glu441Lys Single submitter ⚠
p.Glu456Gln Single submitter ⚠
p.Glu501Lys Single submitter ⚠
p.Glu69Lys Single submitter ⚠
p.Gly101Arg Single submitter ⚠
p.Gly568Ser Single submitter ⚠
p.Gly630Arg Single submitter ⚠
p.Gly686Asp Single submitter ⚠
p.Gly764Ser Single submitter ⚠
p.Gly787Glu Single submitter ⚠
p.Gly787Val Single submitter ⚠
p.Gly803Arg Single submitter ⚠
p.Gly876Asp Single submitter ⚠
p.His615Arg Single submitter ⚠
p.Ile355Thr Single submitter ⚠
p.Ile949Val Single submitter ⚠
p.Leu180Val Single submitter ⚠
p.Leu364Phe Single submitter ⚠
p.Leu925Val Single submitter ⚠
p.Lys450Thr Single submitter ⚠
p.Lys484Arg Single submitter ⚠
p.Lys484Gln Single submitter ⚠
p.Lys635Arg Single submitter ⚠
p.Lys758Asn Single submitter ⚠
p.Lys780Arg Single submitter ⚠
p.Lys817Arg Single submitter ⚠
p.Lys861Arg Single submitter ⚠
p.Pro261Leu Single submitter ⚠
p.Pro291Ser Single submitter ⚠
p.Pro292Ala Single submitter ⚠
p.Pro296Leu Single submitter ⚠
p.Pro490Leu Single submitter ⚠
p.Pro535Gln Single submitter ⚠
p.Pro535Leu Single submitter ⚠
p.Pro608Leu Single submitter ⚠
p.Pro625Leu Single submitter ⚠
p.Pro628Leu Single submitter ⚠
p.Pro642Ala Single submitter ⚠
p.Pro655Ser Single submitter ⚠
p.Pro657Leu Single submitter ⚠
p.Pro662Leu Single submitter ⚠
p.Pro679Ser Single submitter ⚠
p.Pro679Thr Single submitter ⚠
p.Pro738His Single submitter ⚠
p.Pro747Leu Single submitter ⚠
p.Pro747Thr Single submitter ⚠
p.Pro801Thr Single submitter ⚠
p.Pro835Ser Single submitter ⚠
p.Pro844Leu Single submitter ⚠
p.Pro849Ser Single submitter ⚠
p.Pro869Leu Single submitter ⚠
p.Pro92Arg Single submitter ⚠
p.Pro92Leu Single submitter ⚠
p.Pro96Ala Single submitter ⚠
p.Ser117Ala Single submitter ⚠
p.Ser118Ala Single submitter ⚠
p.Ser24Leu Single submitter ⚠
p.Ser24Pro Single submitter ⚠
p.Ser532Leu Single submitter ⚠
p.Ser559Leu Single submitter ⚠
p.Ser563Cys Single submitter ⚠
p.Ser595Arg Single submitter ⚠
p.Ser604Leu Single submitter ⚠
p.Ser609Thr Single submitter ⚠
p.Ser790Phe Single submitter ⚠
p.Ser923Gly Single submitter ⚠
p.Thr653Ala Single submitter ⚠
p.Thr653Pro Single submitter ⚠
p.Thr660Pro Single submitter ⚠
p.Thr796Ile Single submitter ⚠
p.Thr851Arg Single submitter ⚠
p.Thr924Met Single submitter ⚠
p.Val142Ile Single submitter ⚠
p.Val142Leu Single submitter ⚠
p.Val171Ile Single submitter ⚠
p.Val210Met Single submitter ⚠
p.Val332Met Single submitter ⚠
p.Val533Ala Single submitter ⚠
p.Val707Met Single submitter ⚠
p.Val905Met Single submitter ⚠