ZNF207 — 47 ClinVar variants
All ClinVar germline ZNF207 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 41 flagged for review →
47 Uncertain significance
Full ZNF207 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 41
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ZNF207 p.Ala254Glu Uncertain significance Single submitter
- ZNF207 p.Ala356Gly Uncertain significance Single submitter
- ZNF207 p.Arg478Gln Uncertain significance Single submitter
- ZNF207 p.Asn401Ser Uncertain significance Single submitter
- ZNF207 p.Asp111Gly Uncertain significance Single submitter
- ZNF207 p.Asp120Asn Uncertain significance Single submitter
- ZNF207 p.Gln309Leu Uncertain significance Single submitter
- ZNF207 p.Gln99Glu Uncertain significance Single submitter
- ZNF207 p.His447Asp Uncertain significance Single submitter
- ZNF207 p.Ile248Val Uncertain significance Single submitter
- ZNF207 p.Ile418Val Uncertain significance Single submitter
- ZNF207 p.Leu249Val Uncertain significance Single submitter
- ZNF207 p.Leu294Val Uncertain significance Single submitter
- ZNF207 p.Lys299Asn Uncertain significance Single submitter
- ZNF207 p.Met202Ile Uncertain significance Single submitter
- ZNF207 p.Met204Val Uncertain significance Single submitter
- ZNF207 p.Met218Val Uncertain significance Single submitter
- ZNF207 p.Met421Ile Uncertain significance Single submitter
- ZNF207 p.Met438Val Uncertain significance Single submitter
- ZNF207 p.Met468Val Uncertain significance Single submitter
- ZNF207 p.Pro265Gln Uncertain significance Single submitter
- ZNF207 p.Pro269Leu Uncertain significance Single submitter
- ZNF207 p.Pro334Ser Uncertain significance Single submitter
- ZNF207 p.Pro429Ser Uncertain significance Single submitter
- ZNF207 p.Pro456Ser Uncertain significance Single submitter
- ZNF207 p.Pro460Ser Uncertain significance Single submitter
- ZNF207 p.Thr282Lys Uncertain significance Single submitter
- ZNF207 p.Thr286Ile Uncertain significance Single submitter
- ZNF207 p.Thr331Ala Uncertain significance Single submitter
- ZNF207 p.Thr345Ile Uncertain significance Single submitter
- ZNF207 p.Thr349Ala Uncertain significance Single submitter
- ZNF207 p.Tyr138Cys Uncertain significance Single submitter
- ZNF207 p.Val65Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- ZNF207 p.Met202Thr Uncertain significance Single submitter
- ZNF207 p.Phe320Leu Uncertain significance Single submitter
- ZNF207 p.Pro129Leu Uncertain significance Single submitter
- ZNF207 p.Pro175Ser Uncertain significance Single submitter
- ZNF207 p.Pro183Leu Uncertain significance Single submitter
- ZNF207 p.Pro396Leu Uncertain significance Single submitter
- ZNF207 p.Pro436Ser Uncertain significance Single submitter
- ZNF207 p.Pro477Ser Uncertain significance Single submitter
All ZNF207 variants
Uncertain significance 47
- p.Ala254Glu Single submitter ⚠
- p.Ala356Gly Single submitter ⚠
- p.Arg478Gln Single submitter ⚠
- p.Asn199Lys Single submitter
- p.Asn401Ser Single submitter ⚠
- p.Asp111Gly Single submitter ⚠
- p.Asp120Asn Single submitter ⚠
- p.Gln309Leu Single submitter ⚠
- p.Gln99Glu Single submitter ⚠
- p.His447Asp Single submitter ⚠
- p.Ile200Leu Single submitter
- p.Ile248Val Single submitter ⚠
- p.Ile418Val Single submitter ⚠
- p.Leu249Val Single submitter ⚠
- p.Leu294Val Single submitter ⚠
- p.Lys299Asn Single submitter ⚠
- p.Lys358Gln Single submitter
- p.Lys7del Single submitter
- p.Met202Ile Single submitter ⚠
- p.Met202Thr Single submitter ⚠
- p.Met204Val Single submitter ⚠
- p.Met218Val Single submitter ⚠
- p.Met421Ile Single submitter ⚠
- p.Met438Val Single submitter ⚠
- p.Met468Val Single submitter ⚠
- p.Phe320Leu Single submitter ⚠
- p.Pro129Leu Single submitter ⚠
- p.Pro175Ser Single submitter ⚠
- p.Pro183Leu Single submitter ⚠
- p.Pro265Gln Single submitter ⚠
- p.Pro269Leu Single submitter ⚠
- p.Pro334Ser Single submitter ⚠
- p.Pro396Leu Single submitter ⚠
- p.Pro429Ser Single submitter ⚠
- p.Pro436Ser Single submitter ⚠
- p.Pro456Ser Single submitter ⚠
- p.Pro460Ser Single submitter ⚠
- p.Pro461Leu Single submitter
- p.Pro477Ser Single submitter ⚠
- p.Ser291Ter Single submitter
- p.Thr282Lys Single submitter ⚠
- p.Thr286Ile Single submitter ⚠
- p.Thr331Ala Single submitter ⚠
- p.Thr345Ile Single submitter ⚠
- p.Thr349Ala Single submitter ⚠
- p.Tyr138Cys Single submitter ⚠
- p.Val65Ile Single submitter ⚠