KRAS p.Asp154del
c.458ATG[1] · VCV4850885
Likely pathogenic
Single submitter
Classification
Likely pathogenic
ClinVar
Review
Single submitter ★☆☆☆
ClinVar · 1 submitter
gnomAD v4.1
Not reported
no allele count reported in gnomAD v4.1 (AN 1,608,790)
Conditions
1
Fetal anomalies with a likely genetic cause
Computational evidence
| Protein change | ||
| Missense predictors do not apply to this variant type; conservation carries the signal. | ||
| Splicing | ||
| SpliceAI | — | not assessed · substitutions only |
|---|---|---|
| Constraint at this position | ||
| Conservation | phyloP 12 | GERP 1.6, phastCons 1 |
| Region caveats | ||
| Repeat context | seg dup | · reads may not map uniquely · confidence, not pathogenicity |
Population frequency
gnomAD v4.1 · exomes + genomes
No allele count reported in gnomAD v4.1 (AN 1,608,790). This is missing data, not an absence: the variant may or may not be present in gnomAD. Rarity (ACMG PM2) and BA1/BS1 cannot be assessed for it.
Variant & gene context
- Gene
- KRAS
- Protein
- p.Asp154del
- Coding
- c.458ATG[1]
- MANE Select
- NM_004985
- Type
- Microsatellite
- Location
- chr12:25209899 (GRCh38)
- Gene constraint
- LOEUF 0.264 · pLI 1.00 (gnomAD)
- Structure
- AlphaFold pLDDT 91.65 · 549 PDB
- Residue 154
- an α-helix
Disease context
Fetal anomalies with a likely genetic cause
Similar variants
- KRAS p.Asp154Gly Uncertain significance ★ ⚠ same residue
- KRAS p.Asp154Val Uncertain significance ★ ⚠ same residue
- KRAS c.*22C>G Pathogenic ★★ same condition
- KRAS p.Ala59Ser Pathogenic/Likely pathogenic ★★ same condition
- KRAS p.Asp153Gly Pathogenic/Likely pathogenic ★★ same condition
- KRAS p.Gln22Glu Pathogenic ★★ same condition
- KRAS p.Gln22Lys Pathogenic/Likely pathogenic ★★ same condition
- KRAS p.Gly12Asp Pathogenic/Likely pathogenic ★★ same condition
Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →
Cite Sugi Variant
Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/kras-p-asp154del (accessed [today's date]).
Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown