Sugi Variant

Sugi Variant/KRAS

KRAS — 487 ClinVar variants

All ClinVar germline KRAS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 108 flagged for review →

33 Pathogenic · 17 Pathogenic/Likely pathogenic · 38 Likely pathogenic · 22 Conflicting · 31 Benign · 12 Benign/Likely benign · 146 Likely benign · 188 Uncertain significance

Full KRAS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 108

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 9

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predicted LoF vs a conflicting call 1

ClinVar submitters conflict, and it's a predicted loss-of-function change in a gene where LoF causes disease — flagged for review, not resolved (verify NMD-escape for C-terminal truncations). Non-missense.

Predictors lean, ClinVar uncertain 64

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 33

The independent predictors disagree with each other — read with care.

All KRAS variants

Pathogenic 33

Pathogenic/Likely pathogenic 17

Likely pathogenic 38

Conflicting classifications of pathogenicity 22

Benign 31

Benign/Likely benign 12

  • c.112-12C>T Multiple submitters RASopathy
  • c.4+5G>A Multiple submitters hereditary breast carcinoma
  • c.451-5565G>A Multiple submitters Cardiovascular phenotype
  • c.5-18A>G Multiple submitters hereditary breast carcinoma
  • c.-27C>T Multiple submitters
  • c.-48G>A Multiple submitters
  • c.*2626T>G Multiple submitters Noonan syndrome and Noonan-related syndrome
  • c.*298T>G Multiple submitters Noonan syndrome and Noonan-related syndrome
  • c.*4200T>A Multiple submitters Noonan syndrome and Noonan-related syndrome
  • c.*633T>C Multiple submitters Noonan syndrome and Noonan-related syndrome
  • p.Ala66= Multiple submitters RASopathy
  • p.Lys88= Multiple submitters RASopathy

Likely benign 146

Uncertain significance 188