Is KRAS p.Lys88fs (c.261del) pathogenic?

KRAS p.Lys88fs (c.261del) is classified Uncertain significance in KRAS (ClinVar, Single submitter, 1 submitter; last evaluated 2011-07-22). Absent from gnomAD.

How common is KRAS p.Lys88fs (c.261del) in the general population?

KRAS p.Lys88fs (c.261del) is absent from gnomAD (gnomAD).

KRAS p.Lys88fs

c.261del · rs397517038 · VCV45120

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

Consequence

frameshift

predicted LoF

gnomAD v4.1

Not reported

no gnomAD frequency available for this variant

Computational evidence

Protein change
Missense predictors do not apply to this variant type; conservation carries the signal.
Consequence	frameshift	predicted loss-of-function in a LoF-intolerant gene
NMD	predicted	premature termination codon in exon 3 of 5
Splicing
SpliceAI	—	not assessed · substitutions only
Constraint at this position
Conservation	phyloP 7.9	GERP 1.9, phastCons 1

Predicted loss-of-function is descriptive, not an applied PVS1 code.

Population frequency

dbSNP / gnomAD

No gnomAD frequency available for this variant. This is missing data, not an absence: the variant may or may not be present in gnomAD. Rarity (ACMG PM2) and BA1/BS1 cannot be assessed for it.

Variant & gene context

Gene: KRAS
Protein: p.Lys88fs
Coding: c.261del
MANE Select: NM_004985 · reported on NM_033360
dbSNP: rs397517038
Type: Deletion
Location: chr12:25227263 (GRCh38)
Gene constraint: LOEUF 0.264 · pLI 1.00 (gnomAD)
Structure: AlphaFold pLDDT 91.65 · 549 PDB
Residue 88: an α-helix

Full KRAS gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Similar variants

KRAS p.Lys88= Benign/Likely benign ★★ same residue
KRAS p.Glu168fs Uncertain significance ★★ same type
KRAS p.Lys184fs Uncertain significance ★★ same type
KRAS c.291-10del Likely benign ★★ same type
KRAS c.*101_*106del Conflicting classifications of pathogenicity ★ same type
KRAS c.*1615_*1617del Uncertain significance ★ same type
KRAS p.Leu159fs Uncertain significance ★ same type
KRAS p.Lys167del Uncertain significance ★ same type

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/kras-p-lys88fs (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown