KRAS p.Pro34=
c.102A>T · VCV3535702
Likely benign
Single submitter
Classification
Likely benign
ClinVar
Review
Single submitter ★☆☆☆
ClinVar · 1 submitter
gnomAD v4.1
Absent
absent from gnomAD v4.1
Conditions
1
Cardiovascular phenotype
Computational evidence
| Protein change | ||
| Missense predictors do not apply to this variant type; conservation carries the signal. | ||
| Splicing | ||
| SpliceAI | — | not assessed · no allele here is in the release |
|---|---|---|
| Constraint at this position | ||
| Conservation | phyloP 2.7 | GERP -2.9, phastCons 1 |
| Overall | ||
| CADD | 9.354 | PHRED · no single calibrated threshold — expert panels disagree |
Population frequency
gnomAD v4.1 · exomes + genomes
Absent from gnomAD v4.1. Not observed in any sequenced alleles — a rarity signal (ACMG PM2-supporting), not evidence of pathogenicity on its own.
Variant & gene context
- Gene
- KRAS
- Protein
- p.Pro34=
- Coding
- c.102A>T
- MANE Select
- NM_004985
- Type
- single nucleotide variant
- Location
- chr12:25245283 (GRCh38)
- Gene constraint
- LOEUF 0.264 · pLI 1.00 (gnomAD)
- Structure
- AlphaFold pLDDT 91.65 · 549 PDB
- Residue 34
- a UniProt-annotated variant site (in ns3; characterized by a defective gtpase-activating protein sensitivity and a strongly reduced interaction with effectors); a UniProt-annotated variant site (in ns3); a UniProt-annotated variant site (in cfc2; characterized by a defective gtpase-activating protein sensitivity and a strongly reduced interaction with effectors); an α-helix
Similar variants
- KRAS p.Pro34Leu Pathogenic ★★★ same residue
- KRAS p.Pro34Arg Pathogenic/Likely pathogenic ★★ same residue
- KRAS p.Pro34Gln Likely pathogenic ★ same residue
- KRAS c.451-5565G>A Benign/Likely benign ★★ same condition
- KRAS c.451-5617= Benign ★★ same condition
- KRAS c.*103A>G Likely benign ★★ same condition
- KRAS c.*16T>C Likely benign ★★ same condition
- KRAS p.Ala146= Likely benign ★★ same condition
Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →
Cite Sugi Variant
Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/kras-p-pro34 (accessed [today's date]).
Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown