MET p.Phe952fs
c.2855del · rs1794836064 · VCV998144
Computational evidence
| Protein change | ||
| Missense predictors do not apply to this variant type; conservation carries the signal. | ||
| Consequence | frameshift | predicted loss-of-function; NMD-escape possible for C-terminal truncations |
|---|---|---|
| Splicing | ||
| SpliceAI | — | not assessed · substitutions only |
| Constraint at this position | ||
| Conservation | phyloP 0.27 | GERP -3.8, phastCons 0.92 |
Predicted loss-of-function is descriptive, not an applied PVS1 code.
Population frequency
No gnomAD frequency available for this variant. This is missing data, not an absence: the variant may or may not be present in gnomAD. Rarity (ACMG PM2) and BA1/BS1 cannot be assessed for it.
Variant & gene context
- Gene
- MET
- Protein
- p.Phe952fs
- Coding
- c.2855del
- MANE Select
- NM_024755 · reported on NM_000245
- dbSNP
- rs1794836064
- Type
- Deletion
- Location
- chr7:116771618 (GRCh38)
- Structure
- AlphaFold pLDDT 52.38
- Residue 952
- the 'disordered' region
Similar variants
- MET c.2265-42del Uncertain significance ★★ same type
- MET p.Gly1119del Uncertain significance ★★ same type
- MET p.His1052fs Uncertain significance ★★ same type
- MET p.Leu893fs Uncertain significance ★★ same type
- MET p.Met1fs Uncertain significance ★★ same type
- MET p.Phe258fs Uncertain significance ★★ same type
- MET p.Pro356fs Uncertain significance ★★ same type
- MET p.Ser653del Uncertain significance ★★ same type
Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →
Cite Sugi Variant
Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/met-p-phe952fs (accessed [today's date]).
Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown