Is MOGS p.Pro294Leu (c.881C>T) pathogenic?

MOGS p.Pro294Leu (c.881C>T) is classified Benign/Likely benign in MOGS (ClinVar, Multiple submitters, 7 submitters; last evaluated 2026-05-01). AlphaMissense: likely benign (0.0794); Low-frequency (popmax 1.11%, afr); Associated with MOGS-congenital disorder of glycosylation.

What condition is associated with MOGS p.Pro294Leu (c.881C>T)?

MOGS p.Pro294Leu (c.881C>T) is associated with MOGS-congenital disorder of glycosylation (ClinVar).

How common is MOGS p.Pro294Leu (c.881C>T) in the general population?

MOGS p.Pro294Leu (c.881C>T) is low-frequency (popmax 1.11%, afr) (gnomAD).

How is MOGS-CDG inherited?

Typically Autosomal recessive (Orphanet). A genetic counselor can assess individual risk for a family.

What do computational predictors say about MOGS p.Pro294Leu (c.881C>T)?

AlphaMissense predicts likely benign (score 0.0794) — an in-silico prediction, not a clinical call.

MOGS p.Pro294Leu

c.881C>T · rs184209905 · VCV235622

Benign/Likely benign Multiple submitters

Classification

Benign/Likely benign

ClinVar

Review

Multiple submitters ★★☆☆

ClinVar · 7 submitters

AlphaMissense

likely benign

0.0794 · ACMG-weighted

gnomAD v4.1

Rare

low-frequency (popmax 1.11%, afr)

Missense predictors

0/3 damaging

AlphaMissense, REVEL, SaProt

Conditions

MOGS-congenital disorder of glycosylation

Computational evidence

Protein change
AlphaMissense	0.0794	likely benign
REVEL	0.032	moderately benign-leaning
SaProt	LLR -7.68	tolerated
⇒ AlphaMissense, REVEL and SaProt all call this tolerated.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 9.9	GERP 1.4, phastCons 1
Regional constraint	o/e 0.99	unconstrained · MANE · 2,758 bp · p 0.9 · regional, not allelic
Overall
CADD	22.9	PHRED · no single calibrated threshold — expert panels disagree

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 1.11% African / African-American · 830/75,070 alleles

Filtering AF 1.04% ClinGen BA1/BS1 input FAF95, joint · FAF99 1.02%

Overall 0.0578% 933/1,613,892 alleles · low-frequency exomes 491/1,461,550 · genomes 442/152,342 · joint denominator

Ancestry group	Frequency	1 in
African / African-Americangrpmax	1.11%	90
Remaining individualsnot grpmax-eligible	0.0816%	1,226
Admixed American	0.0567%	1,765
Middle Eastern	0.0165%	6,062
European (non-Finnish)	0.00136%	73,750
South Asian	0.0011%	91,060

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: MOGS
Protein: p.Pro294Leu
Coding: c.881C>T
MANE Select: NM_006302
dbSNP: rs184209905
Type: single nucleotide variant
Location: chr2:74462908 (GRCh38)
Gene constraint: LOEUF 0.85 · pLI <0.01 (gnomAD)
Structure: AlphaFold pLDDT 92.42

Full MOGS gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

MOGS-congenital disorder of glycosylation — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

For MOGS-CDG (Orphanet):

Inheritance: Autosomal recessive
Onset: Infancy, Neonatal

Similar variants

MOGS p.Pro294Ala Uncertain significance ★★ ⚠ same residue
MOGS p.Pro294fs Pathogenic ★ same residue
MOGS p.Pro294Ser Uncertain significance ★ ⚠ same residue
MOGS p.Arg495Ter Pathogenic/Likely pathogenic ★★ same condition
MOGS p.Gln124Ter Pathogenic ★★ same condition
MOGS p.Gln505Ter Pathogenic/Likely pathogenic ★★ same condition
MOGS p.Ala22Glu Uncertain significance ★★ ⚠ same condition
MOGS p.Ala292Asp Uncertain significance ★★ ⚠ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/mogs-p-pro294leu (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown