Sugi Variant

Sugi Variant/MOGS

MOGS — 579 ClinVar variants

All ClinVar germline MOGS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 300 flagged for review →

19 Pathogenic · 5 Pathogenic/Likely pathogenic · 11 Likely pathogenic · 12 Conflicting · 2 Benign · 14 Benign/Likely benign · 193 Likely benign · 323 Uncertain significance

Full MOGS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 300

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 7

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 230

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 230

Predictors split 62

The independent predictors disagree with each other — read with care.

All MOGS variants

Pathogenic 19

  • p.Gln124Ter Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Ala19fs Single submitter MOGS-congenital disorder of glycosylation
  • p.Ala360fs Single submitter MOGS-congenital disorder of glycosylation
  • p.Arg506Ter Single submitter MOGS-congenital disorder of glycosylation
  • p.Arg601Ter Single submitter
  • p.Asp141fs Single submitter MOGS-congenital disorder of glycosylation
  • p.Asp212fs Single submitter MOGS-congenital disorder of glycosylation
  • p.Gln408fs Single submitter MOGS-congenital disorder of glycosylation
  • p.His151fs Single submitter MOGS-congenital disorder of glycosylation
  • p.Ile402fs Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu383fs Single submitter MOGS-congenital disorder of glycosylation
  • p.Lys278fs Single submitter MOGS-congenital disorder of glycosylation
  • p.Pro294fs Single submitter MOGS-congenital disorder of glycosylation
  • p.Trp184Ter Single submitter MOGS-congenital disorder of glycosylation
  • p.Trp284Ter Single submitter MOGS-congenital disorder of glycosylation
  • p.Trp462Ter Single submitter MOGS-congenital disorder of glycosylation
  • p.Trp474Ter Single submitter MOGS-congenital disorder of glycosylation
  • p.Arg486Thr No assertion criteria MOGS-congenital disorder of glycosylation
  • p.Phe652Leu No assertion criteria MOGS-congenital disorder of glycosylation ⚠

Pathogenic/Likely pathogenic 5

  • p.Arg495Ter Multiple submitters MOGS-related disorder
  • p.Gln505Ter Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Glu295fs Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Glu418fs Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Val216fs Multiple submitters MOGS-related disorder

Likely pathogenic 11

  • c.353-1G>A Single submitter MOGS-congenital disorder of glycosylation
  • p.Arg446Ter Single submitter
  • p.Arg535Ter Single submitter MOGS-congenital disorder of glycosylation
  • p.Arg700Ter Single submitter MOGS-congenital disorder of glycosylation
  • p.Asp152fs Single submitter MOGS-congenital disorder of glycosylation
  • p.Gly401Ter Single submitter MOGS-congenital disorder of glycosylation
  • p.Gly409Arg Single submitter MOGS-congenital disorder of glycosylation ⚠
  • p.Leu627Pro Single submitter MOGS-congenital disorder of glycosylation ⚠
  • p.Pro350fs Single submitter MOGS-congenital disorder of glycosylation
  • p.Tyr769His Single submitter MOGS-congenital disorder of glycosylation
  • p.Arg110His No assertion criteria MOGS-congenital disorder of glycosylation

Conflicting classifications of pathogenicity 12

  • p.Ala19= Single submitter MOGS-congenital disorder of glycosylation
  • p.Ala621_Glu622insTer Single submitter MOGS-congenital disorder of glycosylation
  • p.Arg167= Single submitter Inborn genetic diseases
  • p.Arg241Cys Single submitter Inborn genetic diseases ⚠
  • p.Arg506Gln Single submitter Inborn genetic diseases ⚠
  • p.Arg563Gln Single submitter MOGS-congenital disorder of glycosylation ⚠
  • p.Arg708His Single submitter Inborn genetic diseases ⚠
  • p.Arg779Gln Single submitter MOGS-congenital disorder of glycosylation ⚠
  • p.Gln377Arg Single submitter Inborn genetic diseases ⚠
  • p.Gly824Asp Single submitter MOGS-congenital disorder of glycosylation ⚠
  • p.His617Gln Single submitter MOGS-congenital disorder of glycosylation ⚠
  • p.Tyr685= Single submitter MOGS-congenital disorder of glycosylation

Benign 2

Benign/Likely benign 14

  • p.Arg29Gly Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Arg613Gln Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Arg678Trp Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Asp239Asn Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Asp529= Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Glu171= Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Glu648= Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Gly4= Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Gly785Ser Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Ile415Met Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Pro293Ser Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Pro294Leu Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Pro704= Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Val673Ile Multiple submitters MOGS-congenital disorder of glycosylation

Likely benign 193

  • c.579+18C>T Multiple submitters MOGS-congenital disorder of glycosylation
  • c.580-16C>A Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Arg110= Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Asp183= Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Asp481= Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Asp527Glu Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Gly125= Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Gly222Arg Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Gly671= Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Gly770= Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Leu503= Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Leu722= Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Leu761= Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Pro114= Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Ser465= Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Thr594= Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Tyr99= Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Val48= Multiple submitters MOGS-congenital disorder of glycosylation
  • p.Val498= Multiple submitters MOGS-congenital disorder of glycosylation
  • c.352+18C>T Single submitter MOGS-congenital disorder of glycosylation
  • c.352+19G>A Single submitter MOGS-congenital disorder of glycosylation
  • c.352+9G>A Single submitter MOGS-congenital disorder of glycosylation
  • c.353-19G>T Single submitter MOGS-congenital disorder of glycosylation
  • c.579+18C>G Single submitter MOGS-congenital disorder of glycosylation
  • c.579+19C>T Single submitter MOGS-congenital disorder of glycosylation
  • c.580-13G>A Single submitter MOGS-congenital disorder of glycosylation
  • c.580-14C>T Single submitter MOGS-congenital disorder of glycosylation
  • c.580-16C>G Single submitter MOGS-congenital disorder of glycosylation
  • c.580-19G>T Single submitter MOGS-congenital disorder of glycosylation
  • c.580-21_580-20delinsG Single submitter
  • c.580-27_580-18del Single submitter MOGS-congenital disorder of glycosylation
  • c.580-275del Single submitter
  • c.580-295_580-294dup Single submitter
  • c.776+11G>A Single submitter MOGS-congenital disorder of glycosylation
  • c.776+20G>A Single submitter MOGS-congenital disorder of glycosylation
  • c.776+9G>A Single submitter MOGS-congenital disorder of glycosylation
  • c.777-10C>T Single submitter
  • c.777-15C>T Single submitter MOGS-congenital disorder of glycosylation
  • c.777-16T>C Single submitter MOGS-congenital disorder of glycosylation
  • c.777-17A>G Single submitter MOGS-congenital disorder of glycosylation
  • c.777-18dup Single submitter MOGS-congenital disorder of glycosylation
  • c.777-6T>G Single submitter MOGS-congenital disorder of glycosylation
  • c.777-7C>G Single submitter MOGS-congenital disorder of glycosylation
  • c.777-8C>A Single submitter MOGS-congenital disorder of glycosylation
  • c.777-9C>T Single submitter MOGS-congenital disorder of glycosylation
  • c.-44C>T Single submitter
  • c.-52G>C Single submitter
  • c.-77G>C Single submitter
  • p.Ala254= Single submitter MOGS-congenital disorder of glycosylation
  • p.Ala292= Single submitter MOGS-congenital disorder of glycosylation
  • p.Ala360Thr Single submitter Inborn genetic diseases
  • p.Ala394= Single submitter MOGS-congenital disorder of glycosylation
  • p.Ala470= Single submitter
  • p.Ala507= Single submitter MOGS-congenital disorder of glycosylation
  • p.Ala537= Single submitter MOGS-congenital disorder of glycosylation
  • p.Ala588= Single submitter MOGS-congenital disorder of glycosylation
  • p.Ala646= Single submitter MOGS-congenital disorder of glycosylation
  • p.Ala717= Single submitter MOGS-congenital disorder of glycosylation
  • p.Ala732= Single submitter MOGS-congenital disorder of glycosylation
  • p.Ala733= Single submitter MOGS-congenital disorder of glycosylation
  • p.Arg24= Single submitter MOGS-congenital disorder of glycosylation
  • p.Arg280= Single submitter MOGS-congenital disorder of glycosylation
  • p.Arg461= Single submitter MOGS-congenital disorder of glycosylation
  • p.Arg506= Single submitter MOGS-congenital disorder of glycosylation
  • p.Arg535= Single submitter MOGS-congenital disorder of glycosylation
  • p.Arg563= Single submitter MOGS-congenital disorder of glycosylation
  • p.Arg565= Single submitter MOGS-congenital disorder of glycosylation
  • p.Arg601= Single submitter MOGS-congenital disorder of glycosylation
  • p.Arg667= Single submitter MOGS-congenital disorder of glycosylation
  • p.Arg708= Single submitter MOGS-congenital disorder of glycosylation
  • p.Arg720= Single submitter MOGS-congenital disorder of glycosylation
  • p.Arg779= Single submitter MOGS-congenital disorder of glycosylation
  • p.Arg812= Single submitter MOGS-congenital disorder of glycosylation
  • p.Arg815= Single submitter MOGS-congenital disorder of glycosylation
  • p.Asn790= Single submitter MOGS-congenital disorder of glycosylation
  • p.Asp141= Single submitter MOGS-congenital disorder of glycosylation
  • p.Asp425= Single submitter MOGS-congenital disorder of glycosylation
  • p.Asp527= Single submitter MOGS-congenital disorder of glycosylation
  • p.Asp566= Single submitter MOGS-congenital disorder of glycosylation
  • p.Asp566Glu Single submitter MOGS-congenital disorder of glycosylation
  • p.Asp584= Single submitter MOGS-congenital disorder of glycosylation
  • p.Asp718= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gln159= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gln342= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gln388= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gln552= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gln663= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gln670= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gln684= Single submitter MOGS-congenital disorder of glycosylation
  • p.Glu191= Single submitter MOGS-congenital disorder of glycosylation
  • p.Glu366= Single submitter MOGS-congenital disorder of glycosylation
  • p.Glu421= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gly118= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gly140= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gly182= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gly25= Single submitter
  • p.Gly25Glu Single submitter MOGS-congenital disorder of glycosylation
  • p.Gly26= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gly302= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gly313= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gly409= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gly416= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gly472= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gly476= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gly619= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gly628= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gly739= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gly816= Single submitter MOGS-congenital disorder of glycosylation
  • p.His102= Single submitter MOGS-congenital disorder of glycosylation
  • p.His455= Single submitter MOGS-congenital disorder of glycosylation
  • p.His509= Single submitter MOGS-congenital disorder of glycosylation
  • p.His590= Single submitter MOGS-congenital disorder of glycosylation
  • p.His745= Single submitter MOGS-congenital disorder of glycosylation
  • p.His784= Single submitter MOGS-congenital disorder of glycosylation
  • p.His823= Single submitter MOGS-congenital disorder of glycosylation
  • p.Ile402= Single submitter MOGS-congenital disorder of glycosylation
  • p.Ile415= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu168= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu205= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu270= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu272= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu298= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu349= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu361= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu399= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu412= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu46= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu475= Single submitter
  • p.Leu490= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu517= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu534= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu541= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu548= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu578= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu582= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu611= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu640= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu643= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu672= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu683= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu698= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu699= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu701= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu709= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu712= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu766= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu787= Single submitter MOGS-congenital disorder of glycosylation
  • p.Leu831= Single submitter MOGS-congenital disorder of glycosylation
  • p.Lys381= Single submitter MOGS-congenital disorder of glycosylation
  • p.Lys660= Single submitter MOGS-congenital disorder of glycosylation
  • p.Lys782= Single submitter MOGS-congenital disorder of glycosylation
  • p.Phe172= Single submitter MOGS-congenital disorder of glycosylation
  • p.Phe240= Single submitter MOGS-congenital disorder of glycosylation
  • p.Phe737= Single submitter MOGS-congenital disorder of glycosylation
  • p.Phe822= Single submitter MOGS-congenital disorder of glycosylation
  • p.Pro112= Single submitter MOGS-congenital disorder of glycosylation
  • p.Pro12= Single submitter MOGS-congenital disorder of glycosylation
  • p.Pro289= Single submitter MOGS-congenital disorder of glycosylation
  • p.Pro311= Single submitter MOGS-congenital disorder of glycosylation
  • p.Pro431= Single submitter MOGS-congenital disorder of glycosylation
  • p.Pro439= Single submitter MOGS-congenital disorder of glycosylation
  • p.Pro464= Single submitter MOGS-congenital disorder of glycosylation
  • p.Pro499= Single submitter MOGS-congenital disorder of glycosylation
  • p.Pro557= Single submitter MOGS-congenital disorder of glycosylation
  • p.Pro579= Single submitter MOGS-congenital disorder of glycosylation
  • p.Pro696= Single submitter MOGS-congenital disorder of glycosylation
  • p.Pro725= Single submitter MOGS-congenital disorder of glycosylation
  • p.Pro79= Single submitter MOGS-congenital disorder of glycosylation
  • p.Ser589= Single submitter MOGS-congenital disorder of glycosylation
  • p.Ser730= Single submitter MOGS-congenital disorder of glycosylation
  • p.Ser734= Single submitter MOGS-congenital disorder of glycosylation
  • p.Ser735= Single submitter MOGS-congenital disorder of glycosylation
  • p.Thr126= Single submitter MOGS-congenital disorder of glycosylation
  • p.Thr127= Single submitter MOGS-congenital disorder of glycosylation
  • p.Thr189= Single submitter MOGS-congenital disorder of glycosylation
  • p.Thr234= Single submitter MOGS-congenital disorder of glycosylation
  • p.Thr358= Single submitter MOGS-congenital disorder of glycosylation
  • p.Thr612= Single submitter MOGS-congenital disorder of glycosylation
  • p.Thr705= Single submitter MOGS-congenital disorder of glycosylation
  • p.Tyr406= Single submitter MOGS-congenital disorder of glycosylation
  • p.Tyr560= Single submitter MOGS-congenital disorder of glycosylation
  • p.Val188= Single submitter MOGS-congenital disorder of glycosylation
  • p.Val203= Single submitter MOGS-congenital disorder of glycosylation
  • p.Val210= Single submitter MOGS-congenital disorder of glycosylation
  • p.Val262= Single submitter MOGS-congenital disorder of glycosylation
  • p.Val277= Single submitter MOGS-congenital disorder of glycosylation
  • p.Val424= Single submitter MOGS-congenital disorder of glycosylation
  • p.Val44= Single submitter MOGS-congenital disorder of glycosylation
  • p.Val458= Single submitter MOGS-congenital disorder of glycosylation
  • p.Val72= Single submitter MOGS-congenital disorder of glycosylation
  • p.Val795= Single submitter MOGS-congenital disorder of glycosylation
  • p.Gln798= No assertion criteria MOGS-related disorder
  • p.His771= No assertion criteria MOGS-related disorder

Uncertain significance 323

Showing the top 300 by review status; the full set is in the sitemap.