Is MYO7A p.Arg873Trp (c.2617C>T) pathogenic?

MYO7A p.Arg873Trp (c.2617C>T) is classified Conflicting classifications of pathogenicity in MYO7A (ClinVar, Conflicting submitters, 12 submitters; last evaluated 2026-01-26). AlphaMissense: ambiguous (0.395); Rare (popmax 0.137%, nfe); Associated with Meniere disease.

What condition is associated with MYO7A p.Arg873Trp (c.2617C>T)?

MYO7A p.Arg873Trp (c.2617C>T) is associated with Meniere disease, Usher syndrome type 1, autosomal recessive nonsyndromic hearing loss 2 (ClinVar).

How common is MYO7A p.Arg873Trp (c.2617C>T) in the general population?

MYO7A p.Arg873Trp (c.2617C>T) is rare (popmax 0.137%, nfe) (gnomAD).

What do computational predictors say about MYO7A p.Arg873Trp (c.2617C>T)?

AlphaMissense predicts ambiguous (score 0.395) — an in-silico prediction, not a clinical call.

MYO7A p.Arg873Trp

c.2617C>T · rs200454015 · VCV43187

Conflicting classifications of pathogenicity Conflicting submitters

Classification

Conflicting classifications of pathogenicity

ClinVar

Review

Conflicting submitters ★☆☆☆

ClinVar · 12 submitters

AlphaMissense

ambiguous

0.395 · ACMG-weighted

gnomAD v4.1

Rare

rare (popmax 0.137%, nfe)

Missense predictors

2/2 damaging

REVEL, SaProt · AlphaMissense no call

Conditions

Meniere disease

Computational evidence

Protein change
AlphaMissense	0.395	ambiguous
REVEL	0.821	moderately pathogenic-leaning
SaProt	LLR -13.33	damaging
⇒ REVEL and SaProt both call this damaging; AlphaMissense makes no call.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 1.1	GERP -0.6, phastCons 1
Regional constraint	o/e 0.95	unconstrained · MANE · 84 kb · p 0.0065 · regional, not allelic
Overall
CADD	25.9	PHRED · no single calibrated threshold — expert panels disagree

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.137% European (non-Finnish) · 1,621/1,179,548 alleles

Filtering AF 0.132% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.13%

Overall 0.116% 1,871/1,611,950 alleles · rare exomes 1,743/1,459,682 · genomes 128/152,268 · joint denominator

Ancestry group	Frequency	1 in
Finnishnot grpmax-eligible	0.25%	399
European (non-Finnish)grpmax	0.137%	728
Remaining individualsnot grpmax-eligible	0.0929%	1,077
African / African-American	0.0307%	3,262
Ashkenazi Jewishnot grpmax-eligible	0.00676%	14,800
Admixed American	0.00668%	14,979
East Asian	0.00446%	22,425
South Asian	0.0044%	22,721

Finnish shows a higher raw frequency than the grpmax group above it. gnomAD excludes bottlenecked groups — Finnish, Ashkenazi Jewish, Amish and “Remaining individuals” — from grpmax, because founder effects make their frequencies unrepresentative for filtering. The table is sorted by frequency, so an excluded group can sit above the grpmax row.

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: MYO7A
Protein: p.Arg873Trp
Coding: c.2617C>T
MANE Select: NM_000260
dbSNP: rs200454015
Type: single nucleotide variant
Location: chr11:77180404 (GRCh38)
Gene constraint: LOEUF 0.995 · pLI <0.01 (gnomAD)
Structure: AlphaFold pLDDT 77.73 · 1 PDB
Residue 873: the 'sah' region

Full MYO7A gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

Meniere disease — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

Also linked: Usher syndrome type 1 autosomal recessive nonsyndromic hearing loss 2 autosomal dominant nonsyndromic hearing loss 11 Usher syndrome type 1B

Similar variants

MYO7A p.Arg873Gln Uncertain significance ★★ ⚠ same residue
MYO7A p.Arg873= Likely benign ★ same residue
MYO7A p.Ala1288Pro Likely pathogenic ★★★ same condition
MYO7A p.Arg1168Gln Pathogenic ★★★ ⚠ same condition
MYO7A p.Arg1873Gln Pathogenic ★★★ ⚠ same condition
MYO7A p.Arg395Cys Likely pathogenic ★★★ ⚠ same condition
MYO7A p.Arg668Cys Pathogenic ★★★ same condition
MYO7A p.Arg853His Likely pathogenic ★★★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/myo7a-p-arg873trp (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown