Is NONO p.Pro429Ser (c.1285C>T) pathogenic?

NONO p.Pro429Ser (c.1285C>T) is classified Uncertain significance in NONO (ClinVar, Single submitter, 1 submitter; last evaluated 2025-09-08). AlphaMissense: likely benign (0.116); Absent from gnomAD v4.1.

How common is NONO p.Pro429Ser (c.1285C>T) in the general population?

NONO p.Pro429Ser (c.1285C>T) is absent from gnomAD v4.1 (gnomAD).

What do computational predictors say about NONO p.Pro429Ser (c.1285C>T)?

AlphaMissense predicts likely benign (score 0.116) — an in-silico prediction, not a clinical call.

NONO p.Pro429Ser

c.1285C>T · VCV4726806

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

likely benign

0.116 · ACMG-weighted

gnomAD v4.1

Absent

absent from gnomAD v4.1

Missense predictors

0/3 damaging

AlphaMissense, REVEL, SaProt

Computational evidence

Protein change
AlphaMissense	0.116	likely benign
REVEL	0.016	strongly benign-leaning
SaProt	LLR -6.78	tolerated
⇒ AlphaMissense, REVEL and SaProt all call this tolerated.
Splicing
SpliceAI	<0.2	no splice effect predicted · four deltas, not one · how we know
Constraint at this position
Conservation	phyloP 7.6	GERP 2, phastCons 1
Regional constraint	o/e 0.45	unconstrained · MANE · 3,077 bp · p 2.4e-12 · regional, not allelic
Overall
CADD	16.82	PHRED · no single calibrated threshold — expert panels disagree

ClinVar classifies this uncertain; the computational predictors unanimously lean tolerated — a triage signal, not a reclassification

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Absent from gnomAD v4.1. Not observed in any sequenced alleles — a rarity signal (ACMG PM2-supporting), not evidence of pathogenicity on its own.

Variant & gene context

Gene: NONO
Protein: p.Pro429Ser
Coding: c.1285C>T
MANE Select: NM_007363
Type: single nucleotide variant
Location: chrX:71299945 (GRCh38)
Structure: AlphaFold pLDDT 77.76 · 9 PDB

Full NONO gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Similar variants

NONO c.651-1G>C Likely pathogenic ★★ same type
NONO p.Ala377= Pathogenic ★★ same type
NONO p.Arg184Ter Pathogenic ★★ same type
NONO p.Ala453Pro Uncertain significance ★★ ⚠ same type
NONO p.Arg202Trp Uncertain significance ★★ ⚠ same type
NONO p.Arg456Ser Uncertain significance ★★ ⚠ same type
NONO p.Asn161Asp Uncertain significance ★★ ⚠ same type
NONO p.Gln380Arg Uncertain significance ★★ ⚠ same type

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/nono-p-pro429ser (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown