NRAS p.Ala11Gly
c.32C>G · VCV4799927
Uncertain significance
Single submitter
Classification
Uncertain significance
ClinVar
Review
Single submitter ★☆☆☆
ClinVar · 1 submitter
AlphaMissense
ambiguous
0.363 · ACMG-weighted
gnomAD v4.1
Absent
absent from gnomAD v4.1
Conditions
1
RASopathy
Computational evidence
| Protein change | ||
| AlphaMissense | 0.363 | ambiguous |
|---|---|---|
| REVEL | 0.329 | indeterminate |
| SaProt | LLR -8.47 | tolerated |
| Splicing | ||
| SpliceAI | — | not assessed · no allele here is in the release |
| Constraint at this position | ||
| Conservation | phyloP 9.9 | GERP 2.5, phastCons 1 |
| Regional constraint | o/e 0.62 | unconstrained · MANE · 7,622 bp · p 6.3e-09 · regional, not allelic |
| Overall | ||
| CADD | 27.0 | PHRED · no single calibrated threshold — expert panels disagree |
AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.
Population frequency
gnomAD v4.1 · exomes + genomes
Absent from gnomAD v4.1. Not observed in any sequenced alleles — a rarity signal (ACMG PM2-supporting), not evidence of pathogenicity on its own.
Variant & gene context
- Gene
- NRAS
- Protein
- p.Ala11Gly
- Coding
- c.32C>G
- MANE Select
- NM_002524
- Type
- single nucleotide variant
- Location
- chr1:114716129 (GRCh38)
- Gene constraint
- LOEUF 0.55 · pLI 0.94 · ClinGen HI 0/3 (gnomAD)
- Structure
- AlphaFold pLDDT 92.56 · 36 PDB
- Residue 11
- an α-helix; a binding site
Similar variants
- NRAS p.Ala11Thr Uncertain significance ★★★ ⚠ same residue
- NRAS p.Gly12Ser Pathogenic ★★★ same condition
- NRAS p.Gly60Glu Pathogenic ★★★ same condition
- NRAS p.Ile24Asn Likely pathogenic ★★★ same condition
- NRAS p.Thr50Ile Pathogenic ★★★ ⚠ same condition
- NRAS p.Thr58Ile Pathogenic ★★★ same condition
- NRAS p.Ala91Val Uncertain significance ★★★ ⚠ same condition
- NRAS p.Arg123Lys Uncertain significance ★★★ ⚠ same condition
Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →
Cite Sugi Variant
Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/nras-p-ala11gly (accessed [today's date]).
Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown