Sugi Variant

Sugi Variant/NRAS

NRAS — 309 ClinVar variants

All ClinVar germline NRAS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 108 flagged for review →

10 Pathogenic · 5 Pathogenic/Likely pathogenic · 11 Likely pathogenic · 17 Conflicting · 18 Benign · 7 Benign/Likely benign · 87 Likely benign · 154 Uncertain significance

Full NRAS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 108

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 7

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 61

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 39

The independent predictors disagree with each other — read with care.

All NRAS variants

Pathogenic 10

Pathogenic/Likely pathogenic 5

  • p.Ala59Thr Multiple submitters Noonan syndrome 6
  • p.Gly12Ala Multiple submitters Noonan syndrome and Noonan-related syndrome
  • p.Gly12Asp Multiple submitters NRAS-related disorder
  • p.Gly12Val Multiple submitters colorectal cancer
  • p.Gly13Asp Multiple submitters acute megakaryoblastic leukemia in down syndrome

Likely pathogenic 11

Conflicting classifications of pathogenicity 17

Benign 18

Benign/Likely benign 7

Likely benign 87

Uncertain significance 154